Molecular & Structural Biology

RSS

Single-cell sequencing sheds light on landscape of myeloid cells in lung tumors

The recent emergence of immunotherapy has marked a sea change in research and care for many forms of cancer, bringing new hope to patients and families around the world. For those who respond to treatment, the results can be dramatic.

10 Apr 2019

Researchers develop new method for identifying compounds that prevent aging

Researchers at Karolinska Institutet in Sweden have developed a new method for identifying compounds that prevent aging.

9 Apr 2019

Researchers discover mechanism to form influenza A virus

The influenza A virus is known to form new strains every year. These strains are the result of small variations occurring at the level of the genome, which cause the virus to become different and no longer recognized by the immune system.

9 Apr 2019

Scientists visualize immune cells fighting blood cancer for the first time

When cancer escapes the immune system, our defenses are rendered powerless and are unable to fight against the disease.

8 Apr 2019

Cellular protein could take on role of restriction factor for hepatitis B virus

Hepatitis B is a viral liver infection that can lead to acute or chronic conditions. Although there is a vaccine that offers protection against the virus, current treatments which prevent the virus from replicating are not curative for infected individuals.

8 Apr 2019

A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage

A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.

5 Apr 2019

Researchers determine atomic structure of fusion protein of a prokaryotic organism

Many viruses, including that perennial winter affliction, the influenza virus, are protected by a lipid membrane on loan from the host cell.

5 Apr 2019

Scientists use a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

5 Apr 2019

New class of molecules could someday become basis for Zika-specific therapeutic

The Zika virus is widely known for causing microcephaly and other brain defects in the fetuses of pregnant, infected women.

4 Apr 2019

Researchers unravel 3D structure of key molecular target for cancer treatment

Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

4 Apr 2019

Gut microbiome signatures in colorectal cancer transcend culture and diet

Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets -- a team of international researchers, from University of Copenhagen among others, find in a new study.

4 Apr 2019

Study evaluates effects of unpaired 1 gene overexpression on lifespan in flies

Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies, and co-authors from the Institute of biology of Komi Science Center of RAS announce the publication of a scientific article titled "Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster" in BMC Systems Biology - an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level.

4 Apr 2019

Analysis of tumor microenvironment to improve effectiveness of preclinical trials

It was shown that co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes in the proliferative activity of the peripheral blood mononuclear cells and mesenchymal stromal cell populations.

3 Apr 2019

Molecular biologists develop pipeline to create and screen new lantibiotic peptides

Nature has provided us with lots of antimicrobials. However, given the rapid increase of antimicrobial resistance, there is a need for the development of new-to-nature antibiotics. Lantibiotics are an interesting option.

3 Apr 2019

Study finds cellular protein as a 'gas pump attendant' of cancer development

The cells which make up our body vary significantly. A liver cell does not look like a muscle cell and each has a unique function. This is because liver cells produce the proteins that characterize them, and muscle cells do the same.

1 Apr 2019

Scientists have more evidence of why clear margins in breast cancer surgery are such good news

When a breast cancer tumor is removed with no signs of cancer left behind, it's great news for patients, and now scientists have more evidence of why.

1 Apr 2019

Researchers discover natural gene therapy for intractable skin disease

Pathogenic gene mutations causing a type of intractable skin disease can be eliminated from some parts of patients' skin as they age, according to Hokkaido University researchers and their collaborators in Japan. This represents a form of natural gene therapy.

1 Apr 2019