Molecular & Structural Biology

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Scientists uncover main mechanisms of fluconazole drug resistance

The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients.

11 Feb 2019

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

A Rutgers-led team has discovered two genes that make some strains of harmful Staphyloccocus bacteria resistant to treatment by copper, a potent and frequently used antibacterial agent.

11 Feb 2019

When genomic sequencing fails to diagnose a rare disease

Routine sequencing has given unprecedented insight into the genetics of rare diseases, but genomics fails to diagnose up to half of patients who are tested. That's the problem German scientists tackled in a recent study in the journal Molecular & Cellular Proteomics.

11 Feb 2019

Novel protein sensor allows researchers to observe nicotine's movements in cells

When a person takes a puff on a cigarette, nicotine floods into the brain, latching onto receptors on the surface of neurons and producing feelings of happiness. But nicotine does not simply stay on the surface of cells--the drug actually permeates into neural cells and alters them from the inside out.

8 Feb 2019

Bariatric surgery changes the way our body senses food

How bariatric surgery helps people with obesity and diabetes is related to changes in the way the gut senses food and nutrients after the operation, researchers report February 5 in the journal Cell Reports.

8 Feb 2019

IDT supports innovative synthetic biology start-ups with grant program

Integrated DNA Technologies’ Synthetic Biology Start-up Grant Program has once again benefited innovative start-ups in their missions to impact sustainable manufacturing, human health, and/or humanitarian causes.

From Integrated DNA Technologies 8 Feb 2019

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, they become toxic and prevent cells working properly.

8 Feb 2019

Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

CRISPR is a technique that is revolutionizing biomedical research through high-precision genome editing. However, even though it allows the creation or correction of mutations consisting of a single or few nucleotides with relative ease, it still possesses limitations upon introducing larger fragments of DNA in the genome.

8 Feb 2019

Mutations in folliculin gene affect embryo implantation

New information is unfolding on the genetic controls of an early turning point in pregnancy. As the tiny, dividing cell mass, the blastocyst, travels from the oviduct and lodges in the wall of the uterus, the cells must exit their pre-implantation state and be ready for post-implantation development.

7 Feb 2019

Insufficient sleep mirrored by DNA from blood leukocytes

An insufficient amount of sleep and qualitatively poor sleep are common among the general population. Prior studies have indicated that prolonged insufficient sleep and poor sleep quality are associated with a heightened risk of cardiovascular diseases, dementia and psychiatric disorders, particularly depression, yet the molecular mechanisms underlying this connection are not well known.

7 Feb 2019

Scientists untangle how microbes manufacture key antibiotic compound

For decades, scientists and doctors have known that bacteria in soil were capable of manufacturing streptozotocin, an antibiotic compound that is also an important treatment for certain types of pancreatic cancer.

7 Feb 2019

New 'WormJam model' could provide valuable insights into human aging

What can worms tell us about human aging? A lot more than you'd think; as research led by the Babraham Institute but involving researchers from multiple disciplines drawn together from across the world has shown.

7 Feb 2019

Rare stem cell may be the root of all metastatic cancers

Researchers have discovered a rogue stem cell that could be the cause of all metastatic cancers. The breakthrough could affect all future research projects.

6 Feb 2019

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

A research team has described the first case of a patient affected by dysfunctions in a nucleoside transporter of the SLC28 gene family, which brings a set of genes which were not related to human pathologies in the scientific bibliography so far.

5 Feb 2019

Scientists shed light on biological process that helps production of healthy cells

Scientists have shed light on a biological process that helps the production of healthy cells, which may aid understanding of neurological diseases and other conditions.

5 Feb 2019

Newly launched CINECA enables researchers to access clinical research data

Registered researchers will have rapid access to an "unprecedented scale" of clinical research data through the new Common Infrastructure for National Cohorts in Europe, Canada and Africa, launched today.

4 Feb 2019

New genetic technique could allow scientists to study how smell affects behavior

Take a whiff when it rains after a dry spell, and breathe in the earthy scent that pervades the air. That smell comes from decomposing bacteria, and scientists call the compound geosmin.

1 Feb 2019

Rhomboid enzymes warp space to break cellular speed limit

Johns Hopkins researchers have found that rhomboid enzymes, which are special proteins that cut other proteins, are able to break the “cellular speed limit” as they move through the cell membrane.

1 Feb 2019

Discovery of proteins that control mucin secretion reveals clues to treating colon, airway diseases

Cells produce mucins at a constant rate, and when exposed to an allergen or pathogen, they produce more mucin in a rapid burst. Both the constant and rapid mucin secretion is controlled by calcium.

1 Feb 2019

Salk researchers pin down why some patients don't respond to common antidepressants

The most commonly prescribed antidepressants, selective serotonin reuptake inhibitors, lift the fog of depression for many people. But for around a third of people with major depressive disorder, SSRIs don't make much of a difference.

1 Feb 2019

Molecular & Structural Biology

Scientists uncover main mechanisms of fluconazole drug resistance

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

When genomic sequencing fails to diagnose a rare disease

Novel protein sensor allows researchers to observe nicotine's movements in cells

Bariatric surgery changes the way our body senses food

IDT supports innovative synthetic biology start-ups with grant program

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

Mutations in folliculin gene affect embryo implantation

Insufficient sleep mirrored by DNA from blood leukocytes

Scientists untangle how microbes manufacture key antibiotic compound

New 'WormJam model' could provide valuable insights into human aging

Rare stem cell may be the root of all metastatic cancers

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

Scientists shed light on biological process that helps production of healthy cells

Newly launched CINECA enables researchers to access clinical research data

New genetic technique could allow scientists to study how smell affects behavior

Rhomboid enzymes warp space to break cellular speed limit

Discovery of proteins that control mucin secretion reveals clues to treating colon, airway diseases

Salk researchers pin down why some patients don't respond to common antidepressants

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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