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Study: Atorvastatin reduces inflammation, thrombogenesis in patients with acute ischemic stroke

The population of northeastern China has a high incidence of ischemic stroke. Previous studies have shown that intracranial large-artery atherosclerosis is one of the main causes of ischemic stroke, and that the mechanisms are related to inflammation and thrombosis of the affected arteries.

12 Sep 2013

Hydroxyurea treatment prevents complications, lowers medical care costs in children sickle cell disease

The benefits of hydroxyurea treatment in people with sickle cell disease are well known -- fewer painful episodes, fewer blood transfusions and fewer hospitalizations. Now new research from the Johns Hopkins Children's Center and other institutions reveals that by preventing such complications, the drug can also considerably lower the overall cost of medical care in children with this condition.

12 Sep 2013

CPT-F antibiotic drug may hold promise for treating potentially fatal MRSA pneumonia

A drug approved just two years ago for treating bacterial infections may hold promise for treating the potentially fatal MRSA pneumonia, according to a Henry Ford Hospital study.

12 Sep 2013

FDA grants Breakthrough Therapy designation to Syndax's entinostat for ER+ breast cancer

Syndax Pharmaceuticals Inc. today announced that the U.S. Food and Drug Administration has designated entinostat as a Breakthrough Therapy for the treatment of locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer when added to exemestane in postmenopausal women whose disease has progressed following non-steroidal aromatase inhibitor therapy.

12 Sep 2013

Undervaccination results in increased risk for whooping cough in young children

Undervaccination – not receiving all recommended vaccinations or not being vaccinated according to the Advisory Committee on Immunization Practices schedule – results in an increased risk for whooping cough in children 3 to 36 months of age, according to a new Kaiser Permanente study.

12 Sep 2013

MicroBiome Therapeutics' NM504 eliminates diarrhea caused by metformin in type 2 diabetes patient

MicroBiome Therapeutics LLC, a biotechnology company developing pharmaceutical and medical food products that shift the human microbiome in specific ways for improved health, today reported publication of a case report suggesting a potentially important new application for its lead product, NM504. NM504 is in clinical development to promote healthy blood glucose levels and metabolic fitness in prediabetic and diabetic populations.

11 Sep 2013

Scientists use nanodiamonds to boost delivery of drug to leukemic cells

By binding multiple molecules of a common leukemia drug with nanodiamonds, scientists from the National University of Singapore (NUS) and University of California, Los Angeles (UCLA) managed to boost the delivery of the drug to leukemic cells and retain the drug within the cells to combat the cancer.

11 Sep 2013

Combination drug does not improve survival in patients with severe alcoholic hepatitis

Four weeks of treatment with a combination of the drug pentoxifylline and the corticosteroid prednisolone did not improve 6-month survival compared with prednisolone alone in 270 patients with severe alcoholic hepatitis, according to a study in the September 11 issue of JAMA.

11 Sep 2013

Large numbers of kidney disease patients inappropriately prescribed statins to lower cholesterol

A new analysis concludes that large numbers of patients in advanced stages of kidney disease are inappropriately being prescribed statins to lower their cholesterol - drugs that offer them no benefit and may increase other health risks such as diabetes, dementia or muscle pain.

11 Sep 2013

Safety labeling changes announced for extended-release and long-acting opioid analgesics

The U.S. Food and Drug Administration today announced class-wide safety labeling changes and new postmarket study requirements for all extended-release and long-acting opioid analgesics intended to treat pain.

11 Sep 2013

Interferon-alpha 2b and ribavirin treatment may be effective for MERS-CoV infection

Treatment with two common drugs reduced viral replication and lung damage when given to monkeys infected with the virus that causes Middle East Respiratory Syndrome. The condition is deadly pneumonia that has killed more than 100 people, primarily in the Middle East.

10 Sep 2013

Omeros seeks EMA's approval to market OMS302 for patients undergoing ILR surgery

Omeros Corporation today announced that it recently submitted a Marketing Authorization Application to the European Medicines Agency seeking approval to market OMS302 for use in patients undergoing intraocular lens replacement surgery in the European Union.

10 Sep 2013

Roche, Inovio Pharmaceuticals to develop DNA-based vaccines for prostate cancer and hepatitis B

Roche and Inovio Pharmaceuticals, Inc. announced today that they have entered into an exclusive worldwide license agreement to research, develop and commercialize Inovio's highly-optimized, multi-antigen DNA immunotherapies targeting prostate cancer and hepatitis B.

10 Sep 2013

Drug can be delivered safely to people with COPD in both "mist" and "dry powder" inhalers, say experts

An international study led by a Johns Hopkins pulmonary expert finds that the drug tiotropium (marketed as the Spiriva brand), can be delivered safely and effectively to people with chronic obstructive pulmonary disease (COPD) in both "mist" and traditional "dry powder" inhalers.

10 Sep 2013

Combination of 2 antiviral drugs improves outcome in monkey model of MERS-CoV infection

National Institutes of Health (NIH) scientists report that a combination of two licensed antiviral drugs reduces virus replication and improves clinical outcome in a recently developed monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.

10 Sep 2013

DO-HEALTH study aims to provide evidence for strategies that prevent chronic disease in seniors

Europe's largest healthy ageing study - DO-HEALTH - which aims to provide evidence for the safety of three simple preventive interventions: vitamin D, omega-3 fatty acids and a simple home exercise programme, has recruited 532 of its target 2,000 seniors.

10 Sep 2013

Scientists develop strain of MERS-CoV that can be used as vaccine against disease

Scientists have developed a strain of the Middle East respiratory syndrome coronavirus (MERS-CoV) that could be used as a vaccine against the disease, according to a study to be published in mBio-, the online open-access journal of the American Society for Microbiology.

10 Sep 2013

Most patients who report statin intolerance can actually tolerate drugs on subsequent trials

Most patients who report statin intolerance, including muscle aches and other side effects from the cholesterol-lowering drugs, can actually tolerate drugs from this class on subsequent trials, according to research from Cleveland Clinic recently released online and forthcoming in the September issue of the American Heart Journal. The study is the largest ever to examine the effects of re-challenging statin-intolerant patients.

10 Sep 2013

Amino acid arginine improves treatment for type 2 diabetes

More than 371 million people worldwide suffer from diabetes, of whom 90% are affected by lifestyle-related diabetes mellitus type 2 (type 2 diabetes).

10 Sep 2013

Undervaccination with diptheria increases risk of whooping cough

Undervaccination with the diptheria, tetanus toxoids and acelluar pertussis (DTaP) vaccine appears to be associated with an increased risk of pertussis (whooping cough) in children 3 to 36 months of age, according to a study by Jason M. Glanz, Ph.D., of the Institute for Health Research at Kaiser Permanente Colorado, Denver.

10 Sep 2013

Pharmaceutical News

Study: Atorvastatin reduces inflammation, thrombogenesis in patients with acute ischemic stroke

Hydroxyurea treatment prevents complications, lowers medical care costs in children sickle cell disease

CPT-F antibiotic drug may hold promise for treating potentially fatal MRSA pneumonia

FDA grants Breakthrough Therapy designation to Syndax's entinostat for ER+ breast cancer

Undervaccination results in increased risk for whooping cough in young children

MicroBiome Therapeutics' NM504 eliminates diarrhea caused by metformin in type 2 diabetes patient

Scientists use nanodiamonds to boost delivery of drug to leukemic cells

Combination drug does not improve survival in patients with severe alcoholic hepatitis

Large numbers of kidney disease patients inappropriately prescribed statins to lower cholesterol

Safety labeling changes announced for extended-release and long-acting opioid analgesics

Interferon-alpha 2b and ribavirin treatment may be effective for MERS-CoV infection

Omeros seeks EMA's approval to market OMS302 for patients undergoing ILR surgery

Roche, Inovio Pharmaceuticals to develop DNA-based vaccines for prostate cancer and hepatitis B

Drug can be delivered safely to people with COPD in both "mist" and "dry powder" inhalers, say experts

Combination of 2 antiviral drugs improves outcome in monkey model of MERS-CoV infection

DO-HEALTH study aims to provide evidence for strategies that prevent chronic disease in seniors

Scientists develop strain of MERS-CoV that can be used as vaccine against disease

Most patients who report statin intolerance can actually tolerate drugs on subsequent trials

Amino acid arginine improves treatment for type 2 diabetes

Undervaccination with diptheria increases risk of whooping cough

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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