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Shipment of Fabrazyme commences from Genzyme's FDA-and-EMA-approved Framingham plant

Genzyme, a Sanofi company, today announced that it has begun shipping Fabrazyme (agalsidase beta) produced at its newly approved plant in Framingham, Massachusetts. As previously communicated, patients in the U.S. are now able to return to full dosing in March. In addition, all new patients in the U.S. are eligible to begin Fabrazyme treatment, at full dosing levels.

2 Mar 2012

Bisphosphonates improve fixation of dental impants in human bones

Millions of people have bad teeth replaced with implants. Often following the procedure, they are unable to chew food for up to six months, until the implant has become fixated in the bone. Now, for the first time, a drug coating that has been tested on humans allows titanium screws to adhere to the bone better and faster. The Link-ping researchers behind the method report that the results are good.

2 Mar 2012

Pharmacological antagonist can inhibit body's response to cold

Researchers at St. Joseph's Hospital and Medical Center in Phoenix, Arizona, in collaboration with Amgen Inc. and several academic institutions, have discovered a way to block the body's response to cold using a drug. This finding could have significant implications in treating conditions such as stroke and cardiac arrest.

2 Mar 2012

Serum taurine may protect against CHD in women with high cholesterol

A nutrient found in the dark meat of poultry may provide protection against coronary heart disease (CHD) in women with high cholesterol, according to a study by researchers at NYU Langone Medical Center.

2 Mar 2012

Treatment with vitamin D reduces size of uterine fibroids

Treatment with vitamin D reduced the size of uterine fibroids in laboratory rats predisposed to developing the benign tumors, reported researchers funded by the National Institutes of Health.

2 Mar 2012

Metastatic melanoma patients with specific genetic mutation benefit from vemurafenib

A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib - increasing median survival from about 6 months to 15.9 months. In patients who responded, the drug stopped cancer progression for a median 6.7 months.

1 Mar 2012

New NPS information on dextropropoxyphene: recommendations and alternatives

NPS has published information online for prescribers to help them prepare for the TGA’s cancellation of Capadex and Paradex, two of the four medicines available in Australia containing dextropropoxyphene.

1 Mar 2012

Parkinson's drug Amantadine may help brain injury victims: Study

The study shows that Amantadine helps boost brain levels of dopamine, a neurotransmitter linked to arousal. And for patients who are in a vegetative state following a brain injury, the drug can help -- possibly by improving responsiveness during rehabilitation.

1 Mar 2012

Patients worried about statin use after label warnings from FDA

The U.S. Food and Drug Administration's announcement Tuesday stated that it would require additional safety warnings on the labels of the cholesterol-lowering drugs. Doctors have said that while the benefits of statins outweigh their potential harm, some patients are alarmed by the new announcement.

1 Mar 2012

Cyclotides discovery may open up new possibilities for immune suppression

A team of researchers at the MedUni Vienna, together with scientists from the University Hospital of Freiburg, has decoded a mechanism in cyclic plant peptides, known as cyclotides, from the family of coffee plants (Rubiaceae) that could open up new possibilities for immune suppression.

1 Mar 2012

ROSETTA Study to compare two therapies in women with overactive bladder

Overactive bladder, or the sudden urge to urinate, affects the quality of life of many women. Studies have shown that not all women respond to or can tolerate oral medications and may benefit from other therapies.

1 Mar 2012

Drawing lessons from emerging economies on increasing access to medicines for NTDs

"At present, the prevailing strategy for improving access to medicines for neglected tropical diseases (NTDs) is drug donation programs, which, despite providing some of the highest economic returns of public health programs ... have uncertain sustainability," Francesca Holt of St. John's College at the University of Cambridge and colleagues write in this PLoS Neglected Tropical Diseases opinion piece.

1 Mar 2012

New prebiotic formula helps colonize newborn's gut with beneficial bacteria

Adding prebiotic ingredients to infant formula helps colonize the newborn's gut with a stable population of beneficial bacteria, and probiotics enhance immunity in formula-fed infants, two University of Illinois studies report.

1 Mar 2012

TWRI team develops new drug against damaging effects of stroke

Scientists at the Toronto Western Research Institute (TWRI), Krembil Neuroscience Center, have developed a drug that protects the brain against the damaging effects of a stroke in a lab setting. This drug has been in development for a few years.

1 Mar 2012

Aspirin may help postmenopausal women reduce risk of trans fat-related stroke

New research shows an increased risk of ischemic stroke in postmenopausal women who consume higher amounts of trans fatty acids, commonly found in baked goods, fried foods, and packaged products. Study findings now available in Annals of Neurology, a journal published by Wiley-Blackwell on behalf of the American Neurological Association and Child Neurology Society, suggest aspirin use may moderate the stroke risk caused by a diet high in trans fats.

1 Mar 2012

Aspirin may reduce risk of trans fat-related stroke in older women

Older women whose diets include a substantial amount of trans fats are more likely than their counterparts to suffer an ischemic stroke, a new study shows.

1 Mar 2012

Inhaled interferon-gamma may effectively treat IPF

Inhaled interferon-gamma may be an effective treatment for idiopathic pulmonary fibrosis (IPF), a chronic and progressive form of lung disease caused by excessive formation of fibrotic, or scar tissue, in the lungs, according to an article published in Journal of Aerosol Medicine and Pulmonary Drug Delivery, a peer-reviewed journal from Mary Ann Liebert, Inc.

1 Mar 2012

More than 80% of anesthesiologists have been involved in surgical catastrophes

More than 80 percent of anesthesiologists have been involved in a catastrophic event involving death or injury to a patient during surgery, suggests a survey study in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

1 Mar 2012

Scientists develop safer and more accurate way to administer warfarin

A team of global scientists, led by researchers at Intermountain Medical Center in Salt Lake City, has developed a safer and more accurate way to administer warfarin, one of the most commonly prescribed but also potentially dangerous medications in the United States.

1 Mar 2012

FDA revises safety information on statin labels

The United States Food and Drug Administration (FDA) announced it is revising safety information on the labels of some statins (cholesterol lowering drugs).

1 Mar 2012