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Chicoric acid a potential candidate for COVID-19 treatment

An article under review in the Scientific Reports journal and currently available on the Research Square* preprint server reports on chicoric acid (CA) as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2022

Noradrenergic drugs could be repurposed to offer effective treatment for Alzheimer's disease symptoms

There is "good evidence" that drugs to treat attention deficit hyperactivity disorder (ADHD) might also successfully treat key aspects of Alzheimer's disease, finds a pooled data analysis of the available research, published online in the Journal of Neurology Neurosurgery & Psychiatry.

6 Jul 2022

Study reports how opioids cause gastric inflammation

Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation.

6 Jul 2022

Research highlights importance of designing effective COVID vaccine allocation strategies

In a recent study posted to the medRxiv* pre-print server, researchers at the University of Melbourne used a modified Susceptible, Exposed, Infectious, and Recovered (SEIR) mathematical model to examine the impact of different vaccine mechanisms and disease characteristics on a population comprised of individuals at high and low risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Novel inhalable COVID-19 vaccine

A recent study published in the Nature Biomedical Engineering journal illustrated a novel inhalable SARS-CoV-2 vaccine candidate centered on exosomes (Exos) coupled with recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD).

5 Jul 2022

How Pfizer won the pandemic, reaping outsize profit and influence

The grinding two-plus years of the pandemic have yielded outsize benefits for one company — Pfizer — making it both highly influential and hugely profitable as covid-19 continues to infect tens of thousands of people and kill hundreds each day.

5 Jul 2022

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

In a recent study published in the journal Science Immunology, researchers in the United States described a rare anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) three antibody cocktail IMM-BCP-01.

4 Jul 2022

West Health issues statement on reports that Senate Democrats will lower prescription drug prices through reconciliation bill

West Health Chief Executive Officer Shelley Lyford issued the following statement on reports that Senate Democrats have reached agreement to move forward on a reconciliation bill that includes major provisions to lower prescription drug prices.

2 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

A recent study posted to the bioRxiv* preprint server supports using mosaic sarbecovirus receptor-binding domain (RBD)-nanoparticles to discover therapeutic pan-variant and pan-sarbecovirus monoclonal antibodies (mAbs) and to induce mAbs by vaccination.

30 Jun 2022

BNT162b2 vaccine induces moderate SARS-CoV-2 immunity in children 5 to 11

In a recent study published in the New England Journal of Medicine, researchers evaluated the effectiveness of the BNT162b2 vaccine against the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron in five to 11-year-old children.

30 Jun 2022

Low-cost intervention could easily be used to right-size opioid prescribing after surgery

A small tweak to hospitals' prescribing systems might make a big difference in reducing risk from leftover opioid pain medication, while still making sure surgery patients get relief from their post-operation pain, a new study suggests.

30 Jun 2022

Study raises questions about drug regulators' independence

Patients and doctors expect drug regulators to provide an unbiased, rigorous assessment of new medicines before they hit the market.

30 Jun 2022

How to develop an "all-variant" COVID vaccine

In a recent study published in Nature Immunology, researchers summarized their observations of humoral immune responses elicited in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infected people. Additionally, they discussed all the types of SARS-CoV-2 infection- and vaccine-induced neutralizing antibodies (nAbs).

30 Jun 2022

Casirivimab/imdevimab improve outcomes in early COVID-19

A new Viruses study determines the effect of casirivimab/imdevimab on IFN-1 and cytokines during SARS-CoV-2 infection.

29 Jun 2022

The past, present and future of aspirin in cardiovascular disease prevention

The International Aspirin Foundation A special edition issue of the Aspirin Summaries has been published '125 years of aspirin - the role of aspirin in CVD' issue 2022 .

29 Jun 2022

Drug-resistant typhoid needs to be treated as a global problem

The bacteria that causes typhoid fever is becoming increasingly resistant to common antibiotics used to treat the disease, with resistant strains spreading to hundreds of countries in the past three decades, new analysis shows.

29 Jun 2022

Study explores antibody responses following three COVID vaccine doses in kidney transplant recipients

In a recent study posted to the medRxiv* pre-print server, Canadian researchers evaluated antibody responses in kidney transplant recipients (KTRs) before and one and three months after receiving the third dose of a messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine.

28 Jun 2022

Study compares protection induced by Delta breakthrough infections vs. COVID boosters against Omicron

Researchers compare the neutralizing ability of antibodies induced by Delta breakthrough infections and a third COVID-19 vaccine against Omicron.

28 Jun 2022

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Pharmaceutical News

Chicoric acid a potential candidate for COVID-19 treatment

Noradrenergic drugs could be repurposed to offer effective treatment for Alzheimer's disease symptoms

Study reports how opioids cause gastric inflammation

Research highlights importance of designing effective COVID vaccine allocation strategies

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Novel inhalable COVID-19 vaccine

How Pfizer won the pandemic, reaping outsize profit and influence

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

West Health issues statement on reports that Senate Democrats will lower prescription drug prices through reconciliation bill

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

BNT162b2 vaccine induces moderate SARS-CoV-2 immunity in children 5 to 11

Low-cost intervention could easily be used to right-size opioid prescribing after surgery

Study raises questions about drug regulators' independence

How to develop an "all-variant" COVID vaccine

Casirivimab/imdevimab improve outcomes in early COVID-19

The past, present and future of aspirin in cardiovascular disease prevention

Drug-resistant typhoid needs to be treated as a global problem

Study explores antibody responses following three COVID vaccine doses in kidney transplant recipients

Study compares protection induced by Delta breakthrough infections vs. COVID boosters against Omicron

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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