Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Positive results from NeuroDerm's ND0611 Phase I/II study for advanced Parkinson's disease

NeuroDerm, Ltd. announced today the results of a Phase I/II safety and pharmacokinetic trial of ND0611, administered as an adjunct therapy to Sinemet, Sinemet CR or Stalevo, in patients with advanced Parkinson's disease.

9 Nov 2011

Benefits of hormone replacement therapy in protecting women from Alzheimer's inconclusive

A rigorous evaluation of the scientific literature reveals that the jury is still out when it comes to hormone replacement therapy and a woman's risk for Alzheimer's disease. Alzforum (http://www.alzforum.org) asked prominent scientists to analyze the results of published studies examining the effects of estrogen or estrogen-plus-progesterone therapy on women.

9 Nov 2011

Ligand third quarter total revenues decrease to $5.7 million

Ligand Pharmaceuticals Incorporated today announced financial results for the three and nine months ended September 30, 2011 and provided a business update.

9 Nov 2011

Higher protein load in critical brain regions linked to severe depression in late life

Depression is one of the most common mental disorders in the elderly, but little is known about the underlying biology of its development in older adults.

8 Nov 2011

Stem cell therapy for Parkinson’s

U.S. researchers have finally found a way to overcome difficulties in coaxing human embryonic stem cells to become the neurons killed by Parkinson's disease.

8 Nov 2011

Polystyrene surface triples number of human ES and iPS cells in culture

By irradiating typical polystyrene lab plates with ultraviolet (UV) waves, Whitehead Institute and MIT scientists have created a surface capable of tripling the number of human embryonic stem (ES) and induced pluripotent stem (iPS) cells that can be grown in culture by current methods. Use of this novel surface also eliminates the need for layers of mouse "feeder cells" to support ES- and iPS-cell growth.

8 Nov 2011

Low-grade inflammatory processes drive development of osteoarthritis

In a study to be published online Nov. 6 in Nature Medicine, investigators at the Stanford University School of Medicine have shown that the development of osteoarthritis is in great part driven by low-grade inflammatory processes.

8 Nov 2011

A person's stroke risk profile may help identify future cognitive problems

A new study shows a person's stroke risk profile, which includes high blood pressure, smoking, and diabetes, may also be helpful in predicting whether a person will develop memory and thinking problems later in the life.

8 Nov 2011

Hirano bodies may play a protective role in progression of Alzheimer's

Hirano bodies are almost indescribably tiny objects found in nerve cells of people suffering from conditions such as Alzheimer's, mad cow and Lou Gehrig's diseases. Yet for decades, researchers weren't sure if these structures helped cause the conditions or appeared after onset of the disease and had some other role.

8 Nov 2011

Researchers discover key mechanism responsible for degrading ubiquitinated protein aggregates

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell.

7 Nov 2011

Unprecedented detailed description of MAP kinase complex structure

In many pharmaceutical company and university laboratories, scientists are looking closely at kinase complexes because the enzymes play key roles in essential cell functions. By taking unusual steps to examine a kinase complex, researchers at Brown University and the National Institutes of Health have found a sought-after prize: an unprecedentedly detailed description of its structure complete with a rare location on its structure that could be a target for new therapeutic drugs.

7 Nov 2011

Chemical breakthrough could simplify drug development process

A new chemical process developed by a team of Harvard researchers greatly increases the utility of Positron Emission Tomography (PET) in creating real-time 3-D images of chemical process occurring inside the human body.

5 Nov 2011

Daily intake of Souvenaid improves memory in people with mild AD

A second clinical trial of the medical food Souvenaid confirmed that daily intake of the nutritional intervention improves memory in people with mild Alzheimer's disease.

5 Nov 2011

Moderate alcohol consumption during adult life, drinking patterns and breast cancer risk

A well-done analysis by Chen WY et al, published in JAMA assesses the association of moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. The authors use prospectively collected data from the 105,986 women enrolled in the Nurses' Health Study followed up from 1980 until 2008 with an early adult alcohol assessment and 8 follow ups.

4 Nov 2011

Quintiles receives two awards for clinical research

Quintiles' digital efforts to bridge the gaps between clinical research, patients and clinical trial participants have been recognized in the form of two International Davey Awards and a Web Health Award this week.

4 Nov 2011

Scientists identify mechanism by which GBM promotes neurodegeneration

Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most common form of brain cancer, promotes the loss of function or death of neurons, a process known as neurodegeneration.

4 Nov 2011

The brain and the heart may not be so different after all

What do heart disease and dementia have in common? Perhaps more than meets the eye, according to researchers at the University of Rochester Medical Center.

3 Nov 2011

Eliminating senescent cells could prevent or delay onset of age-related disorders

Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence that these "deadbeat" cells could contribute to aging and suggests a way to help people stay healthier as they age.

3 Nov 2011

Nmnat1 protein may help prevent brain damage in babies with cerebral palsy

Scientists at Washington University School of Medicine in St. Louis have shown that a protein may help prevent the kind of brain damage that occurs in babies with cerebral palsy.

3 Nov 2011

Birth control shot may impair a person's memory

The birth control shot Depo Provera offers a convenient alternative for women who don't want to remember to take a daily pill. Ironically, research from Arizona State University has shown the shot actually may impair a person's memory.

2 Nov 2011

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Positive results from NeuroDerm's ND0611 Phase I/II study for advanced Parkinson's disease

Benefits of hormone replacement therapy in protecting women from Alzheimer's inconclusive

Ligand third quarter total revenues decrease to $5.7 million

Higher protein load in critical brain regions linked to severe depression in late life

Stem cell therapy for Parkinson’s

Polystyrene surface triples number of human ES and iPS cells in culture

Low-grade inflammatory processes drive development of osteoarthritis

A person's stroke risk profile may help identify future cognitive problems

Hirano bodies may play a protective role in progression of Alzheimer's

Researchers discover key mechanism responsible for degrading ubiquitinated protein aggregates

Unprecedented detailed description of MAP kinase complex structure

Chemical breakthrough could simplify drug development process

Daily intake of Souvenaid improves memory in people with mild AD

Moderate alcohol consumption during adult life, drinking patterns and breast cancer risk

Quintiles receives two awards for clinical research

Scientists identify mechanism by which GBM promotes neurodegeneration

The brain and the heart may not be so different after all

Eliminating senescent cells could prevent or delay onset of age-related disorders

Nmnat1 protein may help prevent brain damage in babies with cerebral palsy

Birth control shot may impair a person's memory

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Reducing polypharmacy through innovative drug formulation technologies

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Reducing polypharmacy through innovative drug formulation technologies

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

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