Gene News and Research

Latest Gene News and Research

Mogrify appoints Dr. Jonathan Appleby as Chief Scientific Officer

Strategic hire bolsters executive leadership team as Company progresses multiple therapeutic programs toward and into clinical development.

From Mogrify 15 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024

Gene editing silences mutant microRNA, restores hearing in adult mice

Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss. They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled the animals to regain hearing. The approach by a research team supported by the National Institutes of Health (NIH), reported in Science Translational Medicine, may eventually lead to potential treatments for inherited hearing loss in people.

13 Jul 2024

Study identifies RFC4 as key player in nasopharyngeal carcinoma

Lichuan Wu et al., at Medical College of Guangxi University, China, presented a comprehensive study on the role of replication factor C subunit 4 (RFC4) in nasopharyngeal carcinoma (NPC), a type of epithelial cancer commonly associated with Epstein-Barr virus infection.

12 Jul 2024

Novel DNA aptamers of melanopsin developed to regulate circadian rhythm

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

12 Jul 2024

Neighborhood disadvantage linked to higher expression of stress-related genes in prostate tumors

Those living in disadvantaged neighborhoods have significantly higher activity of stress-related genes, new research suggests, which could contribute to higher rates of aggressive prostate cancer in African American men.

12 Jul 2024

UQ study offers insights into how Haemophilus influenzae manipulates the immune system

Researchers from The University of Queensland have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.

12 Jul 2024

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

How lipoproteins shape your metabolic health

Study provides a comprehensive review of the lipoprotein pathway and its impact on healthy metabolism, highlighting the roles of HDL, LDL, and other lipoproteins in cardiovascular health and disease.

11 Jul 2024

deCODE genetics study highlights potential drug targets for autoimmune thyroid disease

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study in Nature Communications, comparing over 110 thousand patients with autoimmune thyroid disease (AITD) from Iceland, Finland, UK and USA with 1,1 million controls.

11 Jul 2024

ARPP21 gene mutation could be the cause of ALS

Researchers from the Neuromuscular Diseases Group and the Dementia Neurobiology Group of the Sant Pau Research Institute (IR Sant Pau) and the Memory Unit of the Sant Pau Hospital, led by neurologist Dr. Ricard Rojas-García, have identified a new mutation in the ARPP21 gene that could be the cause of Amyotrophic Lateral Sclerosis (ALS), a devastating neurodegenerative disease.

11 Jul 2024

Researchers discover a new mechanism of resistance to KRAS inhibitors in pancreas cancer

Mutations in the KRAS gene are the primary driver of pancreatic cancer. A new class of drugs known as KRAS inhibitors is showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment.

11 Jul 2024

New study reveals the genetic cause of Parkinson's disease

According to Science Alert, neuroscientists from Johns Hopkins University have recently discovered a new treatment for Parkinson's disease using an FDA-approved cancer drug.

11 Jul 2024

Study reveals how DDM1 protein suppresses 'jumping genes' in plants

International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of "jumping genes."

11 Jul 2024

Gene News and Research

Latest Gene News and Research

Mogrify appoints Dr. Jonathan Appleby as Chief Scientific Officer

One-time prime editing targets common genetic cause of cystic fibrosis

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Gene editing silences mutant microRNA, restores hearing in adult mice

Study identifies RFC4 as key player in nasopharyngeal carcinoma

Novel DNA aptamers of melanopsin developed to regulate circadian rhythm

Neighborhood disadvantage linked to higher expression of stress-related genes in prostate tumors

UQ study offers insights into how Haemophilus influenzae manipulates the immune system

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Enzymatic RNA synthesis paves the way for sustainable therapeutics

How lipoproteins shape your metabolic health

deCODE genetics study highlights potential drug targets for autoimmune thyroid disease

ARPP21 gene mutation could be the cause of ALS

Researchers discover a new mechanism of resistance to KRAS inhibitors in pancreas cancer

New study reveals the genetic cause of Parkinson's disease

Study reveals how DDM1 protein suppresses 'jumping genes' in plants

Kobe University unveils key protein variants in exercise and weight loss

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Prime editing offers promising path to permanent treatment for cystic fibrosis

Industry Focus: Cell & Gene Therapy eBook

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich