Gene News and Research

Latest Gene News and Research

Response to PLX4032 drug short lived in BRAF-mutated metastatic melanoma patients

Researchers with UCLA's Jonsson Comprehensive Cancer Center have found that melanoma patients whose cancers are caused by mutation of the BRAF gene become resistant to a promising targeted treatment through another genetic mutation or the overexpression of a cell surface protein, both driving survival of the cancer and accounting for relapse.

25 Nov 2010

Discovery may lead to new generation of drugs to minimize heart attack risk

An international team led by researchers from the Universities of Leicester and Cambridge has announced a breakthrough in identifying people at risk of developing potentially fatal blood clots that can lead to heart attack.

24 Nov 2010

SIRS-Lab, Pfizer collaborate to improve patients’ outcome with sepsis

SIRS-Lab GmbH, a molecular diagnostics company based in Jena, Germany, and Pfizer Pharma GmbH, headquartered in Berlin, have announced a collaboration in the field of sepsis.

24 Nov 2010

Plant-derived bioscavenger protects against pesticide and nerve agent organophosphate poisoning

The brain is forever chattering to itself, via electrical impulses sent along its hard-wired neuronal "Ethernet." These e-messages are translated into chemical transmissions, allowing communication across the narrow cleft separating one neuron from another or between neurons and their target cells. Of the many kinds of molecules involved in this lively chemical symposium, acetylcholine is among the most critical, performing a host of functions in the central and peripheral nervous system.

24 Nov 2010

NIH expands genetic and clinical research database to provide access to digital study images

The National Institutes of Health has expanded a genetic and clinical research database to give researchers access to the first digital study images.

24 Nov 2010

Hepcidin hormone may be potential therapeutic tool for anemic blood disorders

A hormone made by the body may be a potential therapeutic tool for the treatment of two anemic blood disorders beta-thalassemia and hemochromatosis. The new research was led by scientists at Weill Cornell Medical College and published in the Journal of Clinical Investigation and the journal Blood.

24 Nov 2010

DiaGenic ASA announces subsequent offering of 60,000,000 shares

Reference is made to the stock exchange notice dated 3 November 2010 and the prospectus dated 2 November 2010 regarding a subsequent offering of up to 60,000,000 offer shares in DiaGenic ASA each with a nominal value of NOK 0.05, at a subscription price of NOK 0.50 per share with subscription rights for shareholders of the Company as of 6 October 2010, except shareholders who were allocated shares in the private placement completed on 6 October 2010.

23 Nov 2010

Racial disparities in risk and survival among children with neuroblastoma: Study

Black, Asian, and Native American children are more likely than white and Hispanic children to die after being treated for neuroblastoma, according to new research on the pediatric cancer. The study, of more than 3,500 patients with the disease, is the largest ever to look at racial disparities in risk and survival for the most common solid cancer found in young children.

23 Nov 2010

Erbitux development program featured in ASCO's Clinical Cancer Advances report for third consecutive year

For the third year in a row, the American Society of Clinical Oncology (ASCO) has included Erbitux® (cetuximab) research in its annual report, Clinical Cancer Advances, which features the most significant studies of 2010. The report cites as a notable advance this year the finding that BRAF mutation status is a prognostic, not predictive, marker for Erbitux efficacy in metastatic colorectal cancer (mCRC).

23 Nov 2010

USPTO, EPO issue key patents for Tekmira's LNP technology

Tekmira Pharmaceuticals Corporation, a leading developer of RNA interference therapeutics, announced today that the United States Patent & Trademark Office (USPTO) and the European Patent Office (EPO) have issued key patents covering elements of Tekmira's leading lipid nanoparticle (LNP) technology, which is used to deliver nucleic acid therapeutics, including small interfering RNA (siRNA).

23 Nov 2010

Largest genomic study of human medulloblastomas

Medulloblastomas are the most common malignant brain tumors of childhood, with 40 to 50 percent overall mortality. One of the greatest challenges in treating them is that they vary substantially from patient to patient. In the largest genomic study of human medulloblastomas to date, researchers from Children's Hospital Boston, together with collaborators, have identified six subtypes with distinct molecular "fingerprints" that will improve doctors' ability to direct and individualize treatment.

23 Nov 2010

Mother’s high-fat diet alters fetal genes that regulate circadian rhythm: Study

The link between sleeping and obesity is drawn tighter as a new research published online in the FASEB Journal study shows that what your mother ate when she was pregnant may make you obese or overweight by altering the function of genes (epigenetic changes) that regulate circadian rhythm.

23 Nov 2010

Researcher develops new method that causes cancer cells to self-destruct

Tulane University researcher W T. Godbey has developed a treatment for cancer using a method that causes cancer cells to self-destruct while sparing surrounding healthy cells.

23 Nov 2010

Breakthrough with mutant gene that causes familial ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that eventually destroys most motor neurons, causing muscle weakness and atrophy throughout the body. There is no cure and the current treatment has only a moderate effect on the march of the disease, which typically kills within three to five years. This week in PNAS, a team of Brandeis scientists reports an innovative approach to treating the most common form of familial ALS, commonly known as Lou Gehrig's disease.

23 Nov 2010

Agilent releases GeneSpring GX 11.5 multi-omics bioinformatics system

Agilent Technologies Inc. today introduced GeneSpring GX 11.5, an expansion of its popular bioinformatics software into visualizing and analyzing multiple types of biological data. GeneSpring GX 11.5 now interprets exon microarray, proteomics and metabolomics experiments together for the first time, using a familiar interface.

23 Nov 2010

Different digestive tract bacteria helps infants digest milk more effectively than adults

Infants are more efficient at digesting and utilizing nutritional components of milk than adults due to a difference in the strains of bacteria that dominate their digestive tracts. Researchers from the University of California, Davis, and Utah State University report on genomic analysis of these strains in the November 2010 issue of the journal Applied and Environmental Microbiology identifying the genes that are most likely responsible for this difference.

23 Nov 2010

BioCancell raises $5.1 million by excess demand in public offering

Success for BioCancell Therapeutics Inc. Excess demand in BioCancell's public offering of shares and warrants generated immediate proceeds of $5.1 million, 18% above its stated minimal fundraising goal of $4.3 million.

23 Nov 2010

Variation at gene locus associated with greater reproductive success

Since 1871, when Charles Darwin wrote The Descent of Man, it has been widely accepted that "Variability is the necessary basis for the action of selection." Variability is associated with the ability to adapt, which is clearly beneficial at a species level. But there is increasing evidence that genetic variability may also give rise to advantages at the level of the individual.

22 Nov 2010

Cell Therapeutics announces preliminary results of phase II OPAXIO study for high-grade gliomas

Cell Therapeutics, Inc. announced the preliminary results of a phase II study of paclitaxel poliglumex (OPAXIO) combined with temozolomide (TMZ) and radiotherapy (RT) in patients with newly diagnosed high-grade gliomas.

22 Nov 2010

Researchers develop three-dimensional cancer cell from normal human tissue in culture dish

Researchers at the Stanford University School of Medicine have successfully transformed normal human tissue into three-dimensional cancers in a tissue culture dish for the first time. Watching how the cells behave as they divide and invade surrounding tissue will help physicians better understand how human cancers act in the body. The new technique also provides a way to quickly and cheaply test anti-cancer drugs without requiring laboratory animals.

22 Nov 2010

Gene News and Research

Latest Gene News and Research

Response to PLX4032 drug short lived in BRAF-mutated metastatic melanoma patients

Discovery may lead to new generation of drugs to minimize heart attack risk

SIRS-Lab, Pfizer collaborate to improve patients’ outcome with sepsis

Plant-derived bioscavenger protects against pesticide and nerve agent organophosphate poisoning

NIH expands genetic and clinical research database to provide access to digital study images

Hepcidin hormone may be potential therapeutic tool for anemic blood disorders

DiaGenic ASA announces subsequent offering of 60,000,000 shares

Racial disparities in risk and survival among children with neuroblastoma: Study

Erbitux development program featured in ASCO's Clinical Cancer Advances report for third consecutive year

USPTO, EPO issue key patents for Tekmira's LNP technology

Largest genomic study of human medulloblastomas

Mother’s high-fat diet alters fetal genes that regulate circadian rhythm: Study

Researcher develops new method that causes cancer cells to self-destruct

Breakthrough with mutant gene that causes familial ALS

Agilent releases GeneSpring GX 11.5 multi-omics bioinformatics system

Different digestive tract bacteria helps infants digest milk more effectively than adults

BioCancell raises $5.1 million by excess demand in public offering

Variation at gene locus associated with greater reproductive success

Cell Therapeutics announces preliminary results of phase II OPAXIO study for high-grade gliomas

Researchers develop three-dimensional cancer cell from normal human tissue in culture dish

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting