Gene News and Research

Latest Gene News and Research

Pitt researchers to contribute to building an atlas of cellular senescence

Most cells throughout the body can divide and multiply to replace old cells and repair damaged tissue, but in response to certain stresses, cells can lose their ability to proliferate. These so-called senescent cells accumulate with age and may contribute to cancer and age-related disorders, such as chronic lung disease, cardiovascular disease, frailty and dementia, by pumping out signals that damage neighboring tissues.

21 Oct 2021

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

By combining computational and experimental approaches, University of Pittsburgh School of Medicine and Prairie View A&M University researchers identified cancer drugs that show promise for treating pulmonary hypertension, or PH, a rare and incurable lung disease.

21 Oct 2021

Skeletal muscle in individuals with type 2 diabetes has a different circadian rhythm, research shows

Almost all cells regulate their biological processes over a 24-hour period, otherwise called a cell's circadian rhythm. To do so, cells use a biological clock that cycles different genes on and off throughout the day and night. Scientists already know that our metabolic health can suffer when our biological clock breaks down, due to shift work or sleep disorders, for example. However, it's unclear how exactly the biological clock of people with type 2 diabetes differs from healthy people.

21 Oct 2021

Kidney cancer study provides new insights into tumor invasion and metastatic competence

How cancers metastasize remains poorly understood. The process begins when cancer cells break off from a tumor and invade blood and lymphatic vessels, the body's alleyways. But studying invasion - typically a microscopic process - is challenging.

20 Oct 2021

Novel pathways to target breast cancer identified

A pathway helping the breast cancer protein BRCA1 repair damaged DNA has been identified by University of Queensland researchers in a study that will inform future targeted therapies.

20 Oct 2021

Discovery could help develop a new treatment strategy for patients with melanoma

A new study led by Yale Cancer Center researchers shows that the enzyme KDM5B suppresses anti-melanoma immunity.

20 Oct 2021

New research on phagocytosis and SARS-CoV-2's spike protein

A new study showed that convalescent patient plasma and monoclonal anti-spike antibodies were able to induce phagocytosis at high antibody concentrations.

20 Oct 2021

UVA researchers identify an unknown trigger for epilepsy seizures

Researchers at the University of Virginia School of Medicine have uncovered how problems in cortical microcircuits in the brain can trigger epilepsy seizures.

20 Oct 2021

Researchers identify new gene variants that may cause inherited retinal dystrophies

An international team of researchers, led by scientists at University of California San Diego and Shiley Eye Institute at UC San Diego Health, has broadened and deepened understanding of how inherited retinal dystrophies (IRDs) affect different populations of people and, in the process, have identified new gene variants that may cause the diseases.

20 Oct 2021

Regular testing of SARS-CoV-2 positive vaccinated HCWs may reduce need for long quarantines

A new study published in the journal Annals of Internal Medicine conducted systematic surveillance involving 2,397 HCWs who were fully vaccinated with the Pfizer-BioNTech BNT162 vaccine at the ASST Settelaghi hospitals, Italy, in February 2021.

19 Oct 2021

New technology streamlines the development of gene therapy for genetic blinding disorders

A novel computational platform developed by researchers from the University of Pittsburgh School of Medicine identifies top-performing viral vectors that could deliver gene therapies to the retina with maximum efficiency and precision.

19 Oct 2021

Genetic testing in siblings of newborns with cancer susceptibility genes could reduce deaths by 50%

Genetic testing of the siblings of newborns found to have mutations in any one of 11 genes most commonly associated with childhood-onset cancers could reduce deaths from these rare cancers by about 50%, suggests a study funded by the National Institutes of Health.

19 Oct 2021

Researchers identify the genetic changes responsible for drug resistance in tuberculosis

Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments.

19 Oct 2021

Aging breast tissue can trigger invasive cancer-related genes, finds study

The American Cancer Society estimates that 284,200 women will be newly diagnosed with breast cancer in 2021, and 43,600 will die of the disease - the second highest cause of cancer death in women.

19 Oct 2021

Study highlights the critical role of junk DNA in mammalian development

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution.

19 Oct 2021

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

A research team led by Dr Karen Wing Yee YUEN, Associate Professor from the School of Biological Sciences at the University of Hong Kong (HKU), revealed the mechanism of artificial chromosome (AC) formation in the embryos of the model organism Caenorhabditis elegans, a 1-mm long, transparent nematode.

18 Oct 2021

Two defense systems in bacteria work in a complementary manner to protect from viruses

A new study led by a team of bioscientists from Durham University, UK, in collaboration with University of Liverpool, Northumbria University and New England Biolabs, hopes to exploit newly characterized defense systems in bacteria to compare changes to the human genome.

18 Oct 2021

Gene News and Research

Latest Gene News and Research

Pitt researchers to contribute to building an atlas of cellular senescence

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

Skeletal muscle in individuals with type 2 diabetes has a different circadian rhythm, research shows

Kidney cancer study provides new insights into tumor invasion and metastatic competence

Novel pathways to target breast cancer identified

Discovery could help develop a new treatment strategy for patients with melanoma

New research on phagocytosis and SARS-CoV-2's spike protein

UVA researchers identify an unknown trigger for epilepsy seizures

Researchers identify new gene variants that may cause inherited retinal dystrophies

Regular testing of SARS-CoV-2 positive vaccinated HCWs may reduce need for long quarantines

New technology streamlines the development of gene therapy for genetic blinding disorders

Genetic testing in siblings of newborns with cancer susceptibility genes could reduce deaths by 50%

Researchers identify the genetic changes responsible for drug resistance in tuberculosis

Aging breast tissue can trigger invasive cancer-related genes, finds study

Study highlights the critical role of junk DNA in mammalian development

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

Two defense systems in bacteria work in a complementary manner to protect from viruses

FDA-approved drug encourages sensory neurons to regrow after injury

Famous scientist joins NYU Langone’s Division of Rheumatology

How can framing COVID-19 vaccine side-effects affect an individual's willingness to be vaccinated?

eBook: Using iPSCs models for human disease research and drug discovery eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging