Gene News and Research

Latest Gene News and Research

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

A new study reports the use of metagenomics to detect the virus from wastewater samples, indicating community-level circulating variants that are not yet identified or are present in very low proportions on clinical databases.

15 Feb 2021

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

In a new study, researchers discuss the use of simultaneous sequencing of both human and viral genes to better understand SARS-CoV-2's infection pathway.

15 Feb 2021

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.

15 Feb 2021

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

A new preprint research paper posted to the bioRxiv server demonstrates the potential of using the pre-existing protective responses to produce a broad-spectrum neutralizing response against not just SARS-CoV-2 but other future pathogens.

14 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Researchers at Icahn School of Medicine at Mount Sinai in New York have provided evidence suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was infecting people in New York City (NYC) at least one month before the first case was officially documented in the city.

14 Feb 2021

Scientists identify genes involved in autoimmune Addison's disease

Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition.

13 Feb 2021

LMU researchers study T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

13 Feb 2021

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma.

13 Feb 2021

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs).

13 Feb 2021

Novel finding could lead to better treatments for Type 1 and Type 2 diabetes

Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage.

12 Feb 2021

A brain enzyme plays an important role in waking up neural stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Study reveals detailed map of glioblastoma in genetic, molecular detail

Glioblastoma is among the most aggressive and devastating of cancers. While rare compared with other cancers, it's the most common type of brain cancer.

12 Feb 2021

Study identifies a new factor that increases risk of Alzheimer's disease

People who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health.

12 Feb 2021

Study addresses multiple challenges of the pathogenesis of Huntington's disease

Recent genetic data from patients with Huntington's disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD.

12 Feb 2021

New technology can help develop diagnostic tests for multiple sclerosis

Multiple sclerosis (MS) is the most common neurological disease in young adults, affecting more than 2 million individuals worldwide, with about 1500 cases in Estonia. About 20% of MS patients experience optic neuritis (ON) as the presenting symptom, but not all ON patients develop MS.

12 Feb 2021

Exercise during pregnancy may help mitigate negative effects of parental obesity in children

New research in mice suggests that exercising during pregnancy may help prevent children- especially boys- from developing health problems related to their parents' obesity. The study is published ahead of print in the Journal of Applied Physiology.

11 Feb 2021

New urine test could avoid unnecessary prostate cancer biopsies

A urine test based on University of Michigan Rogel Cancer Center research could have avoided one third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients.

11 Feb 2021

Researchers discover previously-unknown function in enzyme critical for cancer growth

Considered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways.

11 Feb 2021

Gene News and Research

Latest Gene News and Research

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

New mouse model of SARS-CoV-2 infection reflects features of human infection

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Scientists identify genes involved in autoimmune Addison's disease

LMU researchers study T cell exhaustion

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Novel finding could lead to better treatments for Type 1 and Type 2 diabetes

A brain enzyme plays an important role in waking up neural stem cells

Study reveals detailed map of glioblastoma in genetic, molecular detail

Study identifies a new factor that increases risk of Alzheimer's disease

Study addresses multiple challenges of the pathogenesis of Huntington's disease

New technology can help develop diagnostic tests for multiple sclerosis

Exercise during pregnancy may help mitigate negative effects of parental obesity in children

New urine test could avoid unnecessary prostate cancer biopsies

Researchers discover previously-unknown function in enzyme critical for cancer growth

eBook: Using iPSCs models for human disease research and drug discovery eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

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