Gene News and Research

Latest Gene News and Research

Pan-COVID-19 vaccine protects mice against SARS-CoV-2 variants

Researchers in the United States have identified short peptide sequences in the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are immunogenic in a mouse model and may provide protection against viral variants.

5 May 2021

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer's disease (AD), a key step toward eventually testing the approach in humans with the neurodegenerative disease.

5 May 2021

Understanding body clock gene networks could help turn early birds into night owls or vice versa

How body clocks work could lead to science that can turn an early bird into a night owl or vice versa as well as other advances, like helping crops grow all year long.

4 May 2021

Study investigates how Brd4 influences diet-induced obesity

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity.

4 May 2021

New combination treatment could benefit T-ALL patients who do not respond to chemotherapy

T-cell acute lymphoblastic leukemia is an aggressive cancer type that mostly affects children. The standard treatment is chemotherapy, but about one in four patients do not respond or develop resistance to this.

4 May 2021

Scientists identify genetic mutation associated with exfoliation syndrome known to cause glaucoma

A team of researchers from the Agency for Science, Technology and Research's Genome Institute of Singapore and Bioprocessing Technology Institute, as well as Singapore Eye Research Institute, have identified a genetic mutation (functionally defective CYP39A1 gene) associated with exfoliation syndrome, the most common cause of glaucoma.

4 May 2021

New testing technology can accurately differentiate between viral and bacterial infections

When patients complain of coughing, runny nose, sneezing and fever, doctors are often stumped because they have no fundamental tool to identify the source of the respiratory symptoms and guide appropriate treatments.

4 May 2021

Researchers develop new technology to reduce high error rates in gene sequencing

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.

4 May 2021

Certain immune cells can cause damage to the aging nervous system, study finds

Aging is the biggest risk factor for perturbation of the nervous system, even in the absence of distinct disease or trauma.

4 May 2021

New enzyme may help curb chronic kidney disease

University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.

4 May 2021

Unique system detects small changes in DNA structures

Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now.

4 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

In a paper recently uploaded to the preprint server medRxiv by Edward Málaga Trillo et al. (April 29th, 2021), these methods are tested in combination with CRISPR-Cas detection in the field, demonstrating a sensitivity and specificity of 93.8% and 99%, respectively.

4 May 2021

SARS-CoV-2 study in human gut organoids

Most of the major life-threatening symptoms of COVID-19 disease are associated with the host's generation of an exacerbated pro-inflammatory immune response. Many studies have correlated the intensity of the immune response with the severity of disease.

3 May 2021

Tiny 3D brain models could accelerate drug research for multiple sclerosis

Tiny 3-D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS).

3 May 2021

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

An interesting new study discusses how adaptive cellular immunity against the SARS-CoV-2 is dependent on differences in HLA-encoding genes between patients.

3 May 2021

New gene therapy restores dystrophin protein in patients with Duchenne muscular dystrophy

UT Southwestern scientists successfully employed a new type of gene therapy to treat mice with Duchenne muscular dystrophy (DMD), uniquely utilizing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein that is missing in many DMD patients.

3 May 2021

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes.

3 May 2021

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

A recent study published in the Journal Emerging Microbes and Infections has highlighted the emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant with mutations in the membrane protein-encoding gene. Two potential mutations, M:I82T and M:V70L, have been identified within the transmembrane helices, which are expected to improve viral fitness by modulating glucose uptake during replication.

3 May 2021

Could CRISPR be used as a SARS-CoV-2 antiviral?

The potential of using this gene manipulation technology as a SARS-CoV-2 inhibitor or prophylactic is investigated in a review recently uploaded to the journal Experimental Biology and Medicine (April 25th, 2021) by Arnab Banerjee and colleagues.

2 May 2021

Gene News and Research

Latest Gene News and Research

Pan-COVID-19 vaccine protects mice against SARS-CoV-2 variants

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

Understanding body clock gene networks could help turn early birds into night owls or vice versa

Study investigates how Brd4 influences diet-induced obesity

New combination treatment could benefit T-ALL patients who do not respond to chemotherapy

Scientists identify genetic mutation associated with exfoliation syndrome known to cause glaucoma

New testing technology can accurately differentiate between viral and bacterial infections

Researchers develop new technology to reduce high error rates in gene sequencing

Certain immune cells can cause damage to the aging nervous system, study finds

New enzyme may help curb chronic kidney disease

Unique system detects small changes in DNA structures

Four-part small-molecule cocktail can prevent cellular stress

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

SARS-CoV-2 study in human gut organoids

Tiny 3D brain models could accelerate drug research for multiple sclerosis

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

New gene therapy restores dystrophin protein in patients with Duchenne muscular dystrophy

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

Could CRISPR be used as a SARS-CoV-2 antiviral?

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research