Gene News and Research

Latest Gene News and Research

Oxytocinergic and vasopressinergic substances in the brain are involved in guiding social behavior

Research conducted by the University of Valencia (UV) and the Jaume I University of Castellón (UJI), among other institutions, has found alterations to the structure of the brain's nonapeptidergic systems, social behavior and the production of pheromones, traits that reveal sexual dimorphism, in male mice with a lack of the Mecp2 gene.

4 Sep 2020

Spike-based priming leads to high neutralizing activity in animal models

A new report by researchers at the University of Melbourne and published on the preprint server bioRxiv in September 2020 reports on the use of a two-protein two-dose vaccine regimen and its immunogenicity in two animal models.

4 Sep 2020

Researchers identify biomarkers associated with bacterial infection mortality

David Gonzalez's "a-ha" moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient.

4 Sep 2020

CRISPR-based system suppresses genes related to AAV antibody production

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body's immune response to AAV can thwart the whole endeavor.

4 Sep 2020

New consortium established to study the characteristics of blood cells

What's the risk of different human populations to develop a disease? To find out, a team led by Université de Montréal professor Guillaume Lettre created an international consortium to study the blood of hundreds of thousands of people worldwide.

4 Sep 2020

Understanding mechanisms in prostate cancer metastases can provide treatment opportunities

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer.

3 Sep 2020

Research provides a map of coronavirus entry factors across the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases and Cornell University in the US have investigated cellular factors that could be significant for an infection.

3 Sep 2020

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

Researchers at the Icahn School of Medicine at Mount Sinai, New York, have conducted a study that sheds light on the molecular underpinnings of multisystem inflammatory syndrome in children (MIS-C).

3 Sep 2020

Researchers develop new model to predict survival in colorectal cancer

Colorectal cancer (CRC) is the third most common cancer among women and men in the USA, and recent studies have shown an increasing incidence in less developed regions, including Sub-Saharan Africa (SSA).

3 Sep 2020

Scientists identify genetic risk factors underlying penicillin allergy

Penicillin, a life-saving medicine, is the most common cause of drug allergy, with clinical manifestations ranging from temporary skin reactions to life-threatening systemic syndromes.

3 Sep 2020

Two MDC scientists win ERC Starting Grants for pioneering research

Dr. Kathrin de la Rosa and Dr. Ilaria Piazza, who are both junior group leaders at the Max DelbruÌ-ck Center for Molecular Medicine in the Helmholtz Association, have each won European Research Council Starting Grants.

3 Sep 2020

Study shows what happens in the fetal brain affected by congenital Zika syndrome

Zika virus infection during pregnancy can cause severe abnormalities in the fetus, including malformations such as microcephaly.

3 Sep 2020

Improving COVID-19 diagnosis

News-Medical spoke to Yourgene health on their efforts during the COVID-19 pandemic, and how they developed a diagnostic test for COVID-19.

From Yourgene Health 3 Sep 2020

AAV gene therapy often leads to dorsal root ganglion pathology, show studies

A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology.

3 Sep 2020

New Gyrolab AAVX Titer Kit launched to support the development cell and gene therapies

Gyros Protein Technologies AB, a pioneer in automated nanoliter-scale immunoassays and a leading provider of peptide synthesizers and reagents, today announced the introduction of Gyrolab® AAVX Titer Kit for adeno-associated virus (AAV) vector titer determination in AAV vector manufacturing.

From Gyros Protein Technologies AB 3 Sep 2020

Trinity College researchers to participate in gene-based clinical trial for motor neuron disease

Researchers at Trinity College Dublin are to participate in an early phase gene-based clinical trial for motor neuron disease (MND). The research team represents one of only four centres in Europe to take part in such an exciting clinical trial for this devastating disease.

2 Sep 2020

Study offers a possible explanation for prevalence of autism spectrum disorder

Recent estimates indicate a prevalence of autism spectrum disorder (ASD) in the United States of 1 in 59 children with a well-established 4:1 male predominance.

2 Sep 2020

Number of tentacles in sea anemones is defined by amount of food consumed

Your genetic code determines that you will grow two arms and two legs. The same fate is true for all mammals. Similarly, the number of fins a fish has and the number of legs and wings an insect has are embedded in their genetic code.

2 Sep 2020

Study: BIRC2 overexpression could be a key marker for immunotherapy resistance

Johns Hopkins Medicine researchers have added to evidence that a gene responsible for turning off a cell's natural "suicide" signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer.

2 Sep 2020

Negligible ACE2 expression in human beta-cells

Now, a new study published on the preprint server bioRxiv reports that even though the fatality rate is significantly higher in diabetics, there is no evidence that this is due to direct viral infection of pancreatic beta cells, which produce the key hormone in glucose homeostasis, namely insulin.

1 Sep 2020