Gene News and Research

Latest Gene News and Research

Researchers discover treatment for severe auto inflammatory syndrome

Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of--and a treatment for--a previously unknown severe auto inflam-matory syndrome affecting an 18-year-old girl since infancy.

4 Aug 2020

Yale researchers develop new mouse model to study SARS-CoV-2 infection

Researchers at Yale University School of Medicine have developed a new mouse model to study SARS-CoV-2 infection and disease and to accelerate testing of novel treatments and vaccines against the novel coronavirus.

4 Aug 2020

Normal DNA repair process can lead to mutations in cancer

Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer.

4 Aug 2020

Early blood test could detect birth asphyxia

An early blood test could detect which babies deprived of oxygen at birth are at risk of serious neurodisabilities like cerebral palsy and epilepsy.

4 Aug 2020

Research reveals potential early indicator of Fragile X-associated tremor/ataxia syndrome

A new paper in the journal NeuroImage: Clinical from researchers at the University of Kansas reveals a possible early indicator of Fragile X-associated tremor/ataxia syndrome, or FXTAS.

4 Aug 2020

Regulatory mechanisms involved in brain development are same for insects and mammals

With these new findings scientists can potentially better understand the subtle changes that can occur in genes and brain circuits that can lead to mental health disorders such as anxiety and autism spectrum disorders.

4 Aug 2020

Researchers develop scalable strategy to find novel molecular glue degraders

Despite enormous efforts to advance traditional pharmacology approaches, more than three quarters of all human proteins remain beyond the reach of therapeutic development.

4 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

ALKBH5 enzyme shows promising target for cancer immunotherapy

Cancer immunotherapy - a treatment that better enables a patient's own immune system to attack tumors - has shown great potential against some cancers. Yet immunotherapy doesn't work against all tumor types, and many patients who initially respond later develop resistance and relapse.

4 Aug 2020

Artificial intelligence can increase effectiveness of drug repurposing for psychiatric disorders

Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.

3 Aug 2020

Study reveals impact of TP53 gene mutations on MDS severity

Considered the "guardian of the genome," TP53 is the most commonly mutated gene in cancer. TP53's normal function is to detect DNA damage and prevent cells from passing this damage on to daughter cells.

3 Aug 2020

Penn researchers identify genetic driver of Charcot-Marie-Tooth disease

Inherited mutations in a gene that keeps nerve cells intact was shown, for the first time, to be a driver of a neuropathy known as Charcot-Marie-Tooth (CMT) disease.

3 Aug 2020

Extensive study of SARS-CoV-2 sequencing reveals six strains of the virus

The virus causing the COVID-19 pandemic, SARS-CoV-2, presents at least six strains. Despite its mutations, the virus shows little variability, and this is good news for the researchers working on a viable vaccine.

3 Aug 2020

Study shows how G406R single point mutation of the Cav1.2 channel confers autism

Autism spectrum disorder (ASD) is a heterogeneous disorder initiated early in development and characterized by abnormal social communication. Accumulating evidence supports the idea that specific mutations affect regulatory proteins that control arrays of cellular pathways.

3 Aug 2020

Novel short ACE2 isoform may influence SARS-CoV-2 susceptibility

A study led by researchers at the University of Southampton, UK, has identified a novel short isoform of the full-length receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses to gain entry to host cells.

3 Aug 2020

Study investigates genetic determinants of stroke in individuals of African descent

African-Americans have up to three times the risk of dying from strokes as people of European descent, yet there has been little investigation of if and how genetic variants contribute to their elevated stroke risk. Until now.

3 Aug 2020

Researchers identify transferrin as potential contributor to COVID-19 severity

SARS-CoV-2 is the coronavirus that causes COVID-19. It is currently not known why some individuals develop only mild or no symptoms when infected, whilst others experience severe, life-threatening forms of the disease.

3 Aug 2020

Immune system's oldest branches may underpin COVID severity

One of the immune system's oldest branches, called complement, may be influencing the severity of COVID disease, according to a new study from researchers at Columbia University Irving Medical Center.

3 Aug 2020

Long stretches of repeating DNA associated with susceptibility to systemic sclerosis

Researchers from the University of Tsukuba show that long stretches of repeat DNA sequences in the gene FLI1 are associated with susceptibility to systemic sclerosis.

2 Aug 2020

New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

In a groundbreaking bioRxiv study, US researchers demonstrate the capability of next-generation bivalent human adenovirus serotype 5 (hAd5) vaccine for inducing both cellular and humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – using both an S protein sequence optimized for cell surface expression and a conserved nucleocapsid antigen designed to be transported to the endosomal subcellular compartment.

2 Aug 2020

Gene News and Research

Latest Gene News and Research

Researchers discover treatment for severe auto inflammatory syndrome

Yale researchers develop new mouse model to study SARS-CoV-2 infection

Normal DNA repair process can lead to mutations in cancer

Early blood test could detect birth asphyxia

Research reveals potential early indicator of Fragile X-associated tremor/ataxia syndrome

Regulatory mechanisms involved in brain development are same for insects and mammals

Researchers develop scalable strategy to find novel molecular glue degraders

New method reveals the dynamics of cell development and gene activity

ALKBH5 enzyme shows promising target for cancer immunotherapy

Artificial intelligence can increase effectiveness of drug repurposing for psychiatric disorders

Study reveals impact of TP53 gene mutations on MDS severity

Penn researchers identify genetic driver of Charcot-Marie-Tooth disease

Extensive study of SARS-CoV-2 sequencing reveals six strains of the virus

Study shows how G406R single point mutation of the Cav1.2 channel confers autism

Novel short ACE2 isoform may influence SARS-CoV-2 susceptibility

Study investigates genetic determinants of stroke in individuals of African descent

Researchers identify transferrin as potential contributor to COVID-19 severity

Immune system's oldest branches may underpin COVID severity

Long stretches of repeating DNA associated with susceptibility to systemic sclerosis

New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

eBook: Using iPSCs models for human disease research and drug discovery eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research