Gene News and Research

Latest Gene News and Research

METRNL protein identified as key player in cancer progression

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Finding ways to block the effects of METRNL signaling on tumor-infiltrating T cells may allow these immune cells to regain the energy necessary to eliminate tumors.

7 Aug 2024

Study advances understanding of complex neurological disorder

To effectively treat a disease or disorder, doctors must first know the root cause. Such is the case for developmental and epileptic encephalopathies (DEEs), whose root causes can be hugely complex and heterogeneous. Scientists at St. Jude Children's Research Hospital demonstrated the value of DNA methylation patterns for identifying the root cause of DEEs, showing specific gene methylation and genome-wide methylation "episignatures" can help identify the genes that cause DEE. The findings were published today in Nature Communications.

7 Aug 2024

Yogurt with probiotics and honey boosts gut bacteria but no digestive or cognitive benefits

A study in The Journal of Nutrition found that yogurt with B. animalis and honey increases probiotic levels but doesn't affect digestion, cognition, or mood.

6 Aug 2024

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

6 Aug 2024

Study reveals distinct genetic risk factors for influenza and COVID-19

A recent study in Nature Genetics reports that genetic risk factors for influenza and COVID-19 are distinct, highlighting their unique genetic architectures.

6 Aug 2024

Analyzing the impact of heart disease treatments on patients with CHIP

Nicholas A. Marston, MD, MPH, of the TIMI Study Group and Carl J. and Ruth Shapiro Cardiovascular Center at Brigham and Women's Hospital, is the corresponding author of a paper published in Nature Medicine, "Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials."

6 Aug 2024

Accelerated neuronal development linked to intellectual disabilities and autism

The mechanisms underlying intellectual disabilities or autism remain largely unknown. Researchers in the labs of Prof. Pierre Vanderhaeghen and Prof. Vincent Bonin at the VIB-KU Leuven Center for Brain & Disease Research and NERF have discovered that mutations in a gene called SYNGAP1 disrupt the prolonged development of human neurons, which is thought to be essential for normal cognitive function.

6 Aug 2024

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

Grab a drink with friends at happy hour and you're likely to feel chatty, friendly and upbeat. But grab a drink alone and you may experience feelings of depression.

6 Aug 2024

Breakthrough therapy enhances longevity and vitality in aging mice

Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, University of Connecticut researchers have demonstrated a treatment that could lengthen life - and vigor - up to the very end.

6 Aug 2024

Advancing risk stratification for DSP cardiomyopathy with postmortem genetic testing

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Both DSP cardiomyopathy and plakophilin 2 are associated with arrhythmogenic right ventricular cardiomyopathies via a desmosomal mechanism.

6 Aug 2024

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

In this interview conducted at Pittcon 2024, we spoke to Professor John Yates about capturing cardiomyocyte cell-to-cell heterogeneity via shotgun top-down proteomics.

From Pittcon 6 Aug 2024

Beckman Coulter Life Sciences and Illumina Accelerate Oncology Research with Launch of TruSight Oncology 500 DNA/RNA Application

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From Beckman Coulter Life Sciences - Flow Cytometry 6 Aug 2024

MIP Discovery rebrands as Tozaro as it completes transition to supporting cell and gene therapy viral vector analytics and purification

Tozaro’s rationally designed smart polymer affinity reagents offer novel analytics and purification solutions to enhance the development and manufacture of viral vectors in cell and gene therapy.

6 Aug 2024

Reduced folate intake enhances metabolic plasticity in aged mice

Folate fortification of staple foods has long been practiced in many countries.

6 Aug 2024

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms. Epidemiologic data support VPA's role in reducing COVID-19 severity and hospitalization rates.

6 Aug 2024

AI reveals genetic links in aging, chronic diseases, and lifestyle factors across nine organ systems

Research uncovers how genetic factors influence the biological age of different organ systems, revealing their connections to lifestyle, chronic diseases, and potential therapeutic interventions.

5 Aug 2024

Upper respiratory microbiome shows age, sex, and lifestyle impacts, study finds

A Dutch study analyzed the upper respiratory tract microbiome across various age groups, finding significant associations between microbial composition, age, sex, and lifestyle factors like smoking and antibiotic use.

5 Aug 2024

Pomegranate peel extract restores skin balance, fights infections

Pomegranate peel extract effectively restores skin microbiota balance by reducing Staphylococcus aureus and promoting Staphylococcus epidermidis growth, showcasing its potential as a non-toxic antimicrobial treatment.

5 Aug 2024

Enhanced CAR T-cell homing boosts treatment efficacy for osteosarcoma

Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells.

5 Aug 2024

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to evaluate the safety and effectiveness of a cancer vaccine targeting H3 G34-mutant diffuse hemispheric glioma, a highly aggressive brain tumor that is typically found in adolescents and young adults.

5 Aug 2024

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Gene News and Research

Latest Gene News and Research

METRNL protein identified as key player in cancer progression

Study advances understanding of complex neurological disorder

Yogurt with probiotics and honey boosts gut bacteria but no digestive or cognitive benefits

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Study reveals distinct genetic risk factors for influenza and COVID-19

Analyzing the impact of heart disease treatments on patients with CHIP

Accelerated neuronal development linked to intellectual disabilities and autism

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

Breakthrough therapy enhances longevity and vitality in aging mice

Advancing risk stratification for DSP cardiomyopathy with postmortem genetic testing

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Beckman Coulter Life Sciences and Illumina Accelerate Oncology Research with Launch of TruSight Oncology 500 DNA/RNA Application

MIP Discovery rebrands as Tozaro as it completes transition to supporting cell and gene therapy viral vector analytics and purification

Reduced folate intake enhances metabolic plasticity in aged mice

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

AI reveals genetic links in aging, chronic diseases, and lifestyle factors across nine organ systems

Upper respiratory microbiome shows age, sex, and lifestyle impacts, study finds

Pomegranate peel extract restores skin balance, fights infections

Enhanced CAR T-cell homing boosts treatment efficacy for osteosarcoma

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

eBook: Using iPSCs models for human disease research and drug discovery eBook

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering