Gene News and Research

Latest Gene News and Research

$Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture$

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Using extensive genetic data compiled by the UK10K project, an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD) and fracture identified to date.

15 Sep 2015

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Greenovation Biotech GmbH announced today that it has received approval to begin a phase I clinical trial in Europe for its first drug candidate moss-aGal (agalsidase) from Germany's regulatory authority, the Federal Institute for Drugs and Medical Devices (BfArM).

15 Sep 2015

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to cancer patients when rationally combined with immunotherapeutic drugs, according to a review published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

15 Sep 2015

Scientists identify a gene that can cause more aggressive cancer in AML patients

University of Manchester scientists have identified a gene - FOXC1 - that, if switched on, causes more aggressive cancer in a fifth of acute myeloid leukaemia (AML) patients, according to a Cancer Research UK study published in the journal Cancer Cell, today (Monday).

14 Sep 2015

Location-dependent pattern in cilia length in mouse nasal cavity affects sensitivity to odors

Like the hairs they resemble, cilia come in all lengths, from short to long. But unlike the hair on our heads, the length of sensory cilia on nerve cells in our noses is of far more than merely cosmetic significance. A team of researchers from the Perelman School of Medicine at the University of Pennsylvania found a location-dependent pattern in cilia length in the mouse nasal cavity that affects sensitivity to odors.

14 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

Researchers link molecular dots between periodontitis and heart disease

Periodontitis is a risk factor for heart disease. Now a team of researchers has shown that a periodontal pathogen causes changes in gene expression that boost inflammation and atherosclerosis in aortic smooth muscle cells. The research is published ahead of print in Infection and Immunity, a journal of the American Society for Microbiology.

14 Sep 2015

Genetic mutations in deadly Ebola virus appear to block antibody-based treatments

Genetic mutations called "escape variants" in the deadly Ebola virus appear to block the ability of antibody-based treatments to ward off infection, according to a team of U.S. Army scientists and collaborators. Their findings, published online this week in the journal Cell Reports, have implications for the continued development of therapeutics to treat Ebola virus disease, which has claimed the lives of over 11,000 people in West Africa since last year.

14 Sep 2015

nCounterRNA:Protein pancancer immune profiling panel launched by NanoString

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced the commercial launch of the nCounter® RNA:Protein PanCancer Immune Profiling Panel

From NanoString Technologies 11 Sep 2015

Mirati to present data on tyrosine kinase inhibitor at ESMO 2015 European Cancer Congress

Mirati Therapeutics, Inc., an oncology company focusing on genetic and epigenetic drivers of cancer, today announced it will present data on its tyrosine kinase inhibitor, MGCD516, at the ESMO 2015 European Cancer Congress being held in Vienna, Austria from September 25-29, 2015.

11 Sep 2015

Penn Medicine researchers show that DNA editing errors can lead to cancer

Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models.

11 Sep 2015

New collaboration may allow researchers to develop potential gene therapies for pediatric diseases

A new collaboration between Seattle Children's Research Institute and bluebird bio, Inc., a biotechnology company based in Cambridge, Mass. and Seattle, will allow researchers to develop potentially transformative gene therapies for severe genetic and rare pediatric diseases. The collaboration supports pediatric researchers in Seattle who will work with bluebird bio scientists and the company's gene editing technology to research potential cures for genetic pediatric diseases.

11 Sep 2015

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

The National Science Foundation recently funded research aimed at developing an engineered protein-lipid system that simultaneously delivers genes and drugs for the potential treatment of multi-drug resistant cancer cells. The dual-delivery system could also apply to diabetes and other conditions requiring a variety of therapeutic approaches.

11 Sep 2015

Research: Cancer preventative surgery may not be necessary in the future

Surgery to remove the breasts of women at increased risk of developing breast cancer may not be necessary in the future, according to research published in EBioMedicine. Two new studies looking at the effect the menstrual cycle has on the development of breast and ovarian cancer reveal alternative prevention strategies that may render surgery unnecessary.

11 Sep 2015

New AGA guideline recommends colorectal cancer patients to undergo tumor test for Lynch syndrome

All colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new guideline published in Gastroenterology, the official journal of the American Gastroenterological Association.

11 Sep 2015

Hastings Center receives NSF grant for ethical analysis of next-generation prenatal genetic tests

Prenatal testing is changing dramatically. With greatly expanded low-cost genetic tests - some as simple as a maternal blood test - prospective parents will soon be able to learn far more, far earlier, than ever before about their fetuses' medical conditions and risks, and some nonmedical traits.

11 Sep 2015

Inhibition of Tyk2 enzyme promotes anti-cancer activity

Tyrosine kinase 2 (Tyk2) is an enzyme involved in intracellular signalling and has an important role in activating the immune system.

11 Sep 2015

Molecular Health enters into license agreement to supply SafetyMAP software to FDA

Molecular Health has entered into a commercial license to provide the FDA with use of its SafetyMAP software - formally known as Molecular Analysis of Side Effect information (MASE), to provide a comprehensive and dynamic analytical solution for the detection and molecular analysis of drug-induced adverse events for all marketed drugs and for predicting safety issues of new drug candidates.

11 Sep 2015

FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

A compound found in breast milk, named fibroblast growth factor 21 (FGF21), plays a key role in neonatal nutrient absorption and intestinal function. FGF21 also contributes to improve newborn growth and metabolic profile.

11 Sep 2015

EMBL researchers use mass spectrometry data to analyze effects of cancer drugs

Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have developed a new method for studying the targets and effects of cancer drugs using data from discovery mass spectrometry (MS) experiments.

11 Sep 2015

Gene News and Research

Latest Gene News and Research

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Scientists identify a gene that can cause more aggressive cancer in AML patients

Location-dependent pattern in cilia length in mouse nasal cavity affects sensitivity to odors

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Researchers link molecular dots between periodontitis and heart disease

Genetic mutations in deadly Ebola virus appear to block antibody-based treatments

nCounterRNA:Protein pancancer immune profiling panel launched by NanoString

Mirati to present data on tyrosine kinase inhibitor at ESMO 2015 European Cancer Congress

Penn Medicine researchers show that DNA editing errors can lead to cancer

New collaboration may allow researchers to develop potential gene therapies for pediatric diseases

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

Research: Cancer preventative surgery may not be necessary in the future

New AGA guideline recommends colorectal cancer patients to undergo tumor test for Lynch syndrome

Hastings Center receives NSF grant for ethical analysis of next-generation prenatal genetic tests

Inhibition of Tyk2 enzyme promotes anti-cancer activity

Molecular Health enters into license agreement to supply SafetyMAP software to FDA

FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

EMBL researchers use mass spectrometry data to analyze effects of cancer drugs

eBook: Using iPSCs models for human disease research and drug discovery eBook

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich