Genetics News and Research

Latest Genetics News and Research

Study shows genes predict how well diabetes drug will work

How well a person with type 2 diabetes responds to a diabetes drug may well depend upon his or her genetic make-up, according to a study published in the May issue of Diabetes Care. The study found that people who carried certain genotypes responded less favorably to rosiglitazone, a drug often prescribed for people with diabetes, than carriers of other genotypes.

28 Apr 2005

Cancer treatment - timing is everything

Research led by a cancer biologist at The Cleveland Clinic Lerner Research Institute has identified a molecular mechanism that links the body's internal clock to daily variations in how a patient responds to cancer treatment.

28 Apr 2005

Family history DNA sleuths run risk of uncovering infertility

A simple DNA test that is available commercially to help people establish their ancestry could in fact disclose male infertility claims a new study from the University of Leicester.

28 Apr 2005

New centre launched to investigate link between human sugars and disease

A multidisciplinary centre launched today will promote a far broader understanding of the role sugars play in human disease, scientists say.

28 Apr 2005

Abnormal cell division explained

Why do some cancer cells divide not into two, as cells are supposed to do in mitosis, but into three-four new cells that look thoroughly abnormal? This question was raised as early as the 1890s by the German tumor researcher David Hansemann, who could observe the strange mitosis even using the microscopes of his day. Now another David, Lund University researcher David Gisselsson, has found an answer.

28 Apr 2005

Clues about the causes of dementia in Huntington's disease

Scientists at Melbourne's Howard Florey Institute have uncovered a clue about the causes of dementia in Huntington's disease, one of the disease's symptoms, by showing that mice susceptible to Huntington's disease have problems with learning and memory before the diseases' typical movement problems appear.

27 Apr 2005

Asians and Pacific Islanders have the highest levels of iron in their blood

UAB and international scientists studying iron-overload disorders have made the unexpected discovery that Asians and Pacific Islanders have the highest levels of iron in their blood of all racial/ethnic groups who were screened.

27 Apr 2005

Researchers zero in on sleep gene

Zeroing in on the core cellular mechanisms of sleep, researchers at University of Wisconsin Medical School have identified for the first time a single gene mutation that has a powerful effect on the amount of time fruit flies sleep.

27 Apr 2005

Revised Bethesda guidelines effective at identifying patients at risk of colorectal cancer

The revised Bethesda guidelines, used for screening patients for a type of hereditary colorectal cancer, are effective for determining which patients should undergo further genetic testing, according to a study in the April 27 issue of JAMA.

26 Apr 2005

Hereditary colorectal cancer risk lowered in those without certain gene defect

Families with a certain type of hereditary colorectal cancer have a reduced cancer risk if they do not have a gene defect found in many with this type of cancer risk, according to a study in the April 27 issue of JAMA.

26 Apr 2005

Pulsating ultrasound enhances gene therapy for tumors

High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology.

26 Apr 2005

P12 protein influences key cell-signaling pathway

New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body.

26 Apr 2005

Use of positron emission tomography may eliminate more strenuous drug development trials with animals

A number of articles explore the use of positron emission tomography (PET) and small animal imaging—nonsurgical techniques that open the door to understanding and treating human diseases—in the April issue of the Society of Nuclear Medicine’s Journal of Nuclear Medicine.

26 Apr 2005

Genetic screening for iron blood disorder feasible in the workplace

Screening for a condition called haemochromatosis, where iron to builds up in the body, could help prevent organ damage and disease, suggests a study published online today by The Lancet.

26 Apr 2005

Fickle enzyme helps protect, but also can promote heart failure

Enzymes that make the gas nitric oxide (NO) not only protect the heart from damage due to high blood pressure or a heart attack, but also promote heart failure through overgrowth and enlargement of the muscle tissue, say animal researchers at Johns Hopkins.

26 Apr 2005

Gene therapy for Alzheimer's disease shows promise

In the first clinical trial of gene therapy for Alzheimer's disease researchers have produced preliminary evidence that gene therapy may slow the decline in mental functioning associated with Alzheimer's disease.

25 Apr 2005

Substantially more effective therapy than current treatments for Alzheimer's disease

PET scans and cognitive tests have suggested that Alzheimer's disease patients with genetically modified tissue inserted directly into their brains show a reduction in the rate of cognitive decline and increased metabolic activity in the brain, according to a study published in the April 24, 2005 online issue of the journal Nature Medicine by researchers at the University of California, San Diego (UCSD) School of Medicine.

25 Apr 2005

Important new finding about the brain and its stem cells

A family's bravery and generosity in the face of their son's death three years ago has enabled researchers to make an important new finding about the brain and its stem cells.

25 Apr 2005

Pattern of gene expression predicts multiple drug resistance, treatment failure in pediatric leukemia

The discovery of a specific pattern of gene expression linked to multiple-drug resistance of leukemic cells is giving researchers crucial information into why standard therapies fail to cure some children with acute lymphoblastic leukemia (ALL). This finding, from investigators at St. Jude Children’s Research Hospital, could lead to development of drugs that would overcome that resistance.

24 Apr 2005

Increasing benefit seen in novel drug AMN107, that treats Gleevec resistance

An investigational drug is producing powerful responses in patients resistant to Gleevec, the targeted therapy that helps most people diagnosed with chronic myeloid leukemia (CML), an international research team headed by investigators at The University of Texas M. D. Anderson Cancer Center is reporting.

23 Apr 2005