Melanoma

Melanoma is a form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.

What are Melanomas?

The treatment of melanoma may involve surgery, immunotherapy, targeted therapy, chemotherapy or radiotherapy, or a combination of several treatment techniques. Each of these treatments is outlined below.

Melanoma Symptoms and Cause

How is Melanoma Diagnosed and Treated?

Melanoma Prognosis

Melanoma Epidemiology

Melanoma History

Melanoma Research

Choroidal Melanoma

Managing Choroidal Melanomas

Malignant Melanoma

Metastatic Melanoma

Latest Melanoma News and Research

New study overturns ‘snapshot’ model of cell cycle accepted since 1974

Cells have a big decision: Should they replicate or sleep? Healthy cells can go either way. Cancer cells' replication switches are stuck in the 'on' position.

2 Apr 2020

Immunotherapy may benefit mCRPC patients with specific markers of immune activation

Although metastatic castration-resistant prostate cancer typically has limited response to immunotherapy, a subset of patients with pretreatment evidence of active T-cell responses in their tumors experienced prolonged survival following treatment with ipilimumab in a Phase II trial at The University of Texas MD Anderson Cancer Center.

1 Apr 2020

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Study identifies brake on immune activity raising new possibilities for anticancer therapy

The immune system is like a carefully regulated machine, complete with its own built-in "brakes" that prevent it from overreacting and causing excess inflammation in otherwise healthy tissues.

25 Mar 2020

Immunotherapy treatment shows promise for some patients with advanced rare cancers

A study conducted by researchers at The University of Texas MD Anderson Cancer Center demonstrated acceptable toxicity and anti-tumor activity in patients with four types of advanced, hard-to-treat rare cancers.

20 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

'Natural killer' cells could help stop progression of Parkinson's disease

Researchers at the University of Georgia's Regenerative Bioscience Center and their colleagues have found that "natural killer" white blood cells could guard against the cascade of cellular changes that lead to Parkinson's disease and help stop its progression.

16 Mar 2020

Research shows how immune cells act to limit tumor development

How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely.

12 Mar 2020

Blood test for microbial DNA could warn of cancer

A new study published in the journal Nature on March 11, 2020, could transform the currently held views on cancer causation and diagnosis. The researchers have come up with a new technique to detect the presence and type of cancer by looking at microbial DNA circulating in the blood of the person being screened.

11 Mar 2020

Microbial DNA in the blood could help identify who has cancer

When Gregory Poore was a freshman in college, his otherwise healthy grandmother was shocked to learn that she had late-stage pancreatic cancer. The condition was diagnosed in late December. She died in January.

11 Mar 2020

AI taps human knowledge for faster and more accurate cancer diagnosis

A new system combining artificial intelligence with human knowledge promises faster and more accurate cancer diagnosis.

11 Mar 2020

Crushed by a hospital bill? Stand up for yourself

The cost of medical treatment depleted Frances Edwards' savings after she was diagnosed with stage 3 melanoma in October 2016 — even though she has insurance.

11 Mar 2020

Building a 3D scaffolding to monitor tumor growth in real time and controlled environments

Building three-dimensional scaffolding to guide the growth of tumors in controlled environments, to monitor the evolution of each of their cells in real time and to record the release of tumor metabolites and other indicators of cell activity under different conditions.

9 Mar 2020

First-ever study compares cancer prevalence among transgender and cisgender individuals

A new Boston University School of Public Health study is the first-ever population-based study of cancer prevalence in transgender people, estimating 62,530 of the nearly 17 million cancer survivors in the U.S. are transgender.

9 Mar 2020

New 'Immuno-Engineering to Improve Immunotherapy' Center formed to advance cancer therapy

Harvard University's Wyss Institute of Biologically Inspired Engineering and its collaborating institutions, the Harvard John A. Paulson School of Engineering and Applied Sciences, Dana-Farber Cancer Institute, and Harvard's Department of Stem Cell and Regenerative Biology, announce the formation of a new NIH-funded Immuno-Engineering to Improve Immunotherapy Center.

7 Mar 2020

Molecule-sized drills can target diseased cells and kill them in minutes

Molecule-sized drills do the damage they are designed to do. That's bad news for disease.

5 Mar 2020

AI helps reveal apparent cellular distinctions between black and white cancer patients

Scientists at Case Western Reserve University are using Artificial Intelligence (AI) to reveal apparent cellular distinctions between black and white cancer patients, while also exploring potential racial bias in the rapidly developing field of AI.

5 Mar 2020

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

5 Mar 2020

New approach may lead to targeted treatments for certain macrophages or their mechanisms

Can phagocytes act like a Trojan horse, transporting tumour cells within themselves and thereby causing metastases in cancer patients?

5 Mar 2020

Melanoma

Overview

Melanoma Symptoms and Cause

How is Melanoma Diagnosed and Treated?

Melanoma Prognosis

Feature Articles

Melanoma Epidemiology

Melanoma History

Melanoma Research

Choroidal Melanoma

Managing Choroidal Melanomas

Malignant Melanoma

Metastatic Melanoma

Latest Melanoma News and Research

New study overturns ‘snapshot’ model of cell cycle accepted since 1974

Immunotherapy may benefit mCRPC patients with specific markers of immune activation

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Cancer could potentially be treated with new immunotherapy approach, say researchers

Study identifies brake on immune activity raising new possibilities for anticancer therapy

Immunotherapy treatment shows promise for some patients with advanced rare cancers

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

'Natural killer' cells could help stop progression of Parkinson's disease

Research shows how immune cells act to limit tumor development

Blood test for microbial DNA could warn of cancer

Microbial DNA in the blood could help identify who has cancer

AI taps human knowledge for faster and more accurate cancer diagnosis

Crushed by a hospital bill? Stand up for yourself

Building a 3D scaffolding to monitor tumor growth in real time and controlled environments

First-ever study compares cancer prevalence among transgender and cisgender individuals

New 'Immuno-Engineering to Improve Immunotherapy' Center formed to advance cancer therapy

Molecule-sized drills can target diseased cells and kill them in minutes

AI helps reveal apparent cellular distinctions between black and white cancer patients

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

New approach may lead to targeted treatments for certain macrophages or their mechanisms

Investigating Human Disease with Mass Spectrometry-based Proteomics

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Recognizing CDKL5 Deficiency Disorder

Melanoma

Overview

Feature Articles

Melanoma Epidemiology

Melanoma History

Melanoma Research

Choroidal Melanoma

Managing Choroidal Melanomas

Malignant Melanoma

Metastatic Melanoma

Latest Melanoma News and Research

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