Melanoma

Melanoma is a form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.

What are Melanomas?

The treatment of melanoma may involve surgery, immunotherapy, targeted therapy, chemotherapy or radiotherapy, or a combination of several treatment techniques. Each of these treatments is outlined below.

Melanoma Symptoms and Cause

How is Melanoma Diagnosed and Treated?

Melanoma Prognosis

Melanoma History

Melanoma Research

Choroidal Melanoma

Managing Choroidal Melanomas

Malignant Melanoma

Metastatic Melanoma

What are the Statistics of Melanoma?

Latest Melanoma News and Research

Bringing microbiome science into everyday clinical care

The article summarizes results of research and possible future clinical applications of the microbiome and provides instructions for doctors.

13 Jun 2025

New data reveals insights into cancer and cardiovascular safety of JAK inhibitors

Now, the work presented at the 2025 annual EULAR congress in Barcelona adds two important pieces to the puzzle.

12 Jun 2025

Eliminating stellate cells reduces liver metastasis in mouse models

The prestigious journal Hepatology Communications reports on the discovery by the Cancer and Translational Medicine research group of the University of the Basque Country (EHU).

10 Jun 2025

Study reveals a unique vulnerability in melanoma patients with neurofibromin 1 mutations

Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest cancer treatments, a new study shows.

10 Jun 2025

Multimodal AI technology boosts early detection of skin conditions

Detection of melanoma and a range of other skin diseases will be faster and more accurate with a new artificial intelligence (AI) powered tool that analyses multiple imaging types simultaneously.

9 Jun 2025

Breakthrough tumor profiling study offers hope for more precise skin cancer care

Every tumor is unique. This makes it difficult to find the most effective therapy for treatment. The Tumor Profiler Center of the University Hospital Zurich, the University of Zurich, ETH Zurich and the University Hospital Basel has now carried out a study in which nine different molecular biological technologies were used to precisely measure the properties of the tumor in four weeks and enable a precise treatment decision.

6 Jun 2025

Scientists unlock potential of cytokine adjuvants in mRNA vaccines

In the quest to design vaccines that better help the body's immune system fight disease, scientists are always looking for more tools for their arsenal.

6 Jun 2025

Mitochondrial DNA variant predicts resistance to melanoma immunotherapy

Results from a new study help resolve the decade-long mystery of why many patients with the deadliest form of skin cancer do not respond to the latest cancer treatments.

6 Jun 2025

Tumor profiling study advances personalized cancer treatment

5 Jun 2025

Genetic mutation identified as key factor in immunotherapy resistance for melanoma

Tests in 1,225 patients with the most deadly form of skin cancer reveal for the first time a genetic trait among most of those who did not respond to the latest cancer treatments, known as immune checkpoint inhibitors.

5 Jun 2025

DANTE trial reveals promising outcomes for shortened immunotherapy in advanced melanoma

Reducing the length of immunotherapy treatment for an advanced skin cancer did not significantly diminish disease control when compared to giving treatments over a longer period, according to breakthrough research led by the Universities of Sheffield and Leeds and Sheffield Teaching Hospitals NHS Foundation Trust.

5 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Engineered viruses and gene therapy halt tumor growth and extend survival in mice

This study reveals the potential of engineered phage-IL-12 therapy in melanoma, enhancing immune response and tumor destruction in aggressive cancer models.

2 Jun 2025

New combination treatment offers hope for immune checkpoint blockade resistant skin cancers

A study has revealed why some patients don't respond to immune checkpoint blockade (ICB) therapy for solid cancer tumors and identifies a new combination treatment.

2 Jun 2025

Cancer survivor population in the US expected to surpass 22 million by 2035

The number of people living with a history of cancer in the United States is estimated at 18.6 million as of January 1, 2025 and projected to exceed 22 million by 2035, according to a new report, Cancer Treatment and Survivorship Statistics, 2025, led by the American Cancer Society (ACS).

31 May 2025

Mass General Brigham researchers share cancer research discoveries at ASCO 2025

Researchers from Mass General Brigham will present research discoveries and outcomes from clinical trials in cancer at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, held May 30-June 3, in Chicago.

30 May 2025

Muscle wasting in cancer tied to blood vessel dysfunction

A dysfunction in muscle blood vessels could be to blame for the weak muscles and weight loss that most cancer patients experience, according to a new study from University of Illinois Chicago researchers.

29 May 2025

Study reveals how PAX3 protein drives melanoma growth

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal differentiation, which is the final stage where a cell becomes specialized and cell division ends.

19 May 2025

Novel nanoparticle could make ultrasound-based cancer treatments more effective and safer

Researchers have created a new kind of nanoparticle that could make ultrasound-based cancer treatments more effective and safer, while also helping prevent tumors from coming back.

14 May 2025

Annual blood test could detect cancer earlier and save lives

A single blood test, designed to pick up chemical signals indicative of the presence of many different types of cancer, could potentially thwart progression to advanced disease while the malignancy is still at an early stage and amenable to treatment in up to half of cases, suggests a modelling study published in the open access journal BMJ Open.

8 May 2025