Metabolism News and Research

Latest Metabolism News and Research

Enrollment complete in Gemin X Pharmaceuticals' Phase 2 clinical trial of obatoclax for SCLC

Gemin X Pharmaceuticals, a clinical stage biopharmaceutical company developing novel, targeted cancer therapeutics, today announced the completion of patient enrollment in a Phase 2 clinical trial of the Company's lead product candidate obatoclax (GX15-070) for the treatment of extensive-stage small cell lung cancer (SCLC). The trial is designed to evaluate the efficacy and safety of obatoclax, a novel pan Bcl-2 inhibitor, in combination with standard chemotherapy for the first-line treatment of patients with SCLC.

29 Mar 2010

Redpoint Bio announces revenue of $1.9M for full-year 2009

Redpoint Bio Corporation, a company focused on the development of healthier foods and beverages and new approaches to the treatment of diabetes and obesity, today announced financial and operational results for the quarter and year ended December 31, 2009.

29 Mar 2010

Surgery helps reduce weight from 118 kg to 62.8 kg

Weight control is one of the important topics for modern people. In addition to proper diet, regular exercise and appropriate use of medicine, obese suffers may consider weight loss surgeries for faster effects. The first successful case in NCKU Hospital reduced her weight from 118 kg to 62.8 kg one year after the surgery.

29 Mar 2010

High fructose corn syrup linked to skyrocketing rates of obesity

According to the Centers for Disease Control and Prevention, the rates of obesity in the United States have skyrocketed since the introduction of high fructose corn syrup in 1970. In that time, obesity rates have gone from 15 percent of the U.S. population to roughly one-third.

29 Mar 2010

ER stress response is major driver of insulin resistance, say researchers

Biologists have long known that an enzyme called the PI 3-kinase is a crucial actor in the main molecular pathway for insulin signaling in cells. Researchers at Joslin Diabetes Center now have uncovered startling evidence that one of the proteins in this enzyme also drives a pathway with an opposite result-triggering a stress response that leads to insulin resistance.

29 Mar 2010

TB-causing bacteria can hijack fat metabolism to drive progression of the disease

The factors instrumental in triggering latent tuberculosis infection to progress into active disease have long remained elusive to researchers. New insight into the mystery is provided by Professor David Russell, speaking at the Society for General Microbiology's spring meeting in Edinburgh today. His work could help develop innovative strategies for treating the disease.

29 Mar 2010

Pathway Genomics Genetic Health Report helps make more informed health and lifestyle decisions

You may not suffer from any form of heart disease, high blood pressure, or high cholesterol, but you could have a predisposition for these conditions based on more than just your lifestyle or diet. A family history of diabetes, gout, high blood pressure or high blood cholesterol can increase one’s risk regardless of lifestyle.

27 Mar 2010

Roche NimbleGen' s microarray technologies help identify genes responsible for CRC

In a recently published study in the journal Genome Research, a team of scientists led by Dr. Shaying Zhao at the University of Georgia have developed a novel cross-species comparative genomics and oncology strategy for cancer driver gene discovery, using microarray technologies from Roche NimbleGen, that differs fundamentally from current approaches which focus on human cancers only.

26 Mar 2010

Working of master regulator protein phosphatase 1

Protein phosphorylation is a process by which proteins are flipped from one activation state to another. It is a crucial function for most living beings, since phosphorylation controls nearly every cellular process, including metabolism, gene transcription, cell-cycle progression, cytoskeletal rearrangement and cell movement.

26 Mar 2010

Sirolimus-based immunosuppression improves survivals after transplantation for HCC

A recent study found that sirolimus-based immunosuppression following liver transplantation in patients with non-resectable hepatocellular carcinoma (liver cancer) significantly increases survival rates for this patient population.

26 Mar 2010

Changing drug therapy can help breast cancer patients get full benefit of tamoxifen treatment

26 Mar 2010

Standard HCV therapy less effective in urban minority patients: Study

A recent study confirms that the standard hepatitis C therapy, pegylated interferon and ribavirin, is significantly less effective in urban minority patients treated in an ordinary clinical practice setting compared with results produced during clinical trials.

26 Mar 2010

AVASTIN receives Health Canada approval for patients with GBM

Roche Canada announced today that Health Canada has approved AVASTIN(R) (bevacizumab), as a single agent, for the treatment of patients with glioblastoma multiforme, the most aggressive primary malignant brain tumour, after relapse or disease progression, following prior therapy.

26 Mar 2010

Findings suggest adipose inflammation is necessary for fat cell turnover

It has been a common opinion that inflammation in adipose tissue may cause insulin resistance, and thereby type 2 diabetes. However, recent research from the Swedish medical university Karolinska Institutet, published in the New England Journal of Medicine, question the theory that inflammation in the body fat is only pernicious.

25 Mar 2010

Changing drug therapy can help breast cancer patients get full benefit of Tamoxifen

Recently published research has shown that some breast cancer patients taking tamoxifen may not be getting the full benefit of their treatment because they have also been taking selective serotonin reuptake inhibitors (SSRIs), prescribed drugs that inhibit the effect of an important enzyme. Now researchers have developed a strategy for overcoming this problem, the seventh European Breast Cancer Conference (EBCC7) in Barcelona will hear today (Wednesday).

25 Mar 2010

Bariatric surgery may delay onset of type 2 diabetes, says study

A team of researchers, led by a UC Davis veterinary endocrinologist, has shown for the first time that a surgical procedure in rats that is similar to bariatric surgery in humans can delay the onset of type 2 diabetes.

25 Mar 2010

Breathing diesel exhaust during pregnancy linked with sluggishness in offspring

Breathing diesel exhaust during pregnancy is associated with sluggishness in offspring. Researchers writing in BioMed Central's open access journal Particle and Fibre Toxicology studied the effects of pollution exposure in mice, finding that the offspring of mothers who breathed diesel fumes while pregnant were less likely to show spontaneous movement.

23 Mar 2010

CTSI licenses GeneGo's pathway analysis suite and database searching tool

GeneGo, Inc., a leading provider of software and databases for systems biology, today announced that the Indiana Clinical and Translational Sciences Institute has licensed its pathway analysis suite MetaCore and its database searching tool Eureka.

23 Mar 2010

Researchers investigate link between consumption of high-fructose corn syrup and obesity

A Princeton University research team has demonstrated that all sweeteners are not equal when it comes to weight gain: Rats with access to high-fructose corn syrup gained significantly more weight than those with access to table sugar, even when their overall caloric intake was the same.

23 Mar 2010

Novo Nordisk Foundation donates $160M to University of Copenhagen for metabolic research

The Center will conduct research into Type 2 diabetes, among other diseases, and will acquire the capacities and resources to establish itself as one of the leading international research centers in the world. With 885 million Danish kroner (approx. 160 million US Dollars) from the Novo Nordisk Foundation, a team of 5 leading research scientists will be headhunted by the University to oversee "The Novo Nordisk Foundation Center for Basic Metabolic Research".

From Novo Nordisk 23 Mar 2010

Metabolism News and Research

Latest Metabolism News and Research

Enrollment complete in Gemin X Pharmaceuticals' Phase 2 clinical trial of obatoclax for SCLC

Redpoint Bio announces revenue of $1.9M for full-year 2009

Surgery helps reduce weight from 118 kg to 62.8 kg

High fructose corn syrup linked to skyrocketing rates of obesity

ER stress response is major driver of insulin resistance, say researchers

TB-causing bacteria can hijack fat metabolism to drive progression of the disease

Pathway Genomics Genetic Health Report helps make more informed health and lifestyle decisions

Roche NimbleGen' s microarray technologies help identify genes responsible for CRC

Working of master regulator protein phosphatase 1

Sirolimus-based immunosuppression improves survivals after transplantation for HCC

Changing drug therapy can help breast cancer patients get full benefit of tamoxifen treatment

Standard HCV therapy less effective in urban minority patients: Study

AVASTIN receives Health Canada approval for patients with GBM

Findings suggest adipose inflammation is necessary for fat cell turnover

Changing drug therapy can help breast cancer patients get full benefit of Tamoxifen

Bariatric surgery may delay onset of type 2 diabetes, says study

Breathing diesel exhaust during pregnancy linked with sluggishness in offspring

CTSI licenses GeneGo's pathway analysis suite and database searching tool

Researchers investigate link between consumption of high-fructose corn syrup and obesity

Novo Nordisk Foundation donates $160M to University of Copenhagen for metabolic research

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