Psoriasis

Psoriasis is a chronic, immune-mediated disease that results from the overproduction of skin cells, resulting in their accumulation on the surface of the skin, which causes red, scaly plaques that may itch and bleed. It is estimated that approximately 7.5 million Americans and nearly 3 percent of the world's population are living with psoriasis and nearly one-quarter of those people have cases that are considered moderate to severe.

What is Psoriasis?

Psoriasis represents a chronic inflammatory skin condition with a complex pathophysiology and significant genetic background.

Psoriasis Epidemiology

Psoriasis Clinical Classification

What causes Psoriasis?

Psoriasis Systemic Treatment

Psoriasis Phototherapy

Psoriasis Drug Development

Diet and Psoriasis

Psoriasis Diagnosis

Psoriasis Treatment

Psoriasis Photochemotherapy

Psoriasis Prognosis

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Psoriasis Genetic Factors

Living With Psoriasis

Psoriasis Types

Psoriasis Topical Treatment

Psoriasis Historical Treatment

Psoriasis Alternative Therapy

Latest Psoriasis News and Research

Single DNA injection provides long-lasting weight loss in mouse study

Scientists at The Wistar Institute have shown that a single injection of a small, circular piece of genetic instructions can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long as incretin-mimicking drugs like Ozempic and Wegovy.

26 Jun 2026

Secukinumab rapidly reduces hidden joint inflammation in psoriasis patients

Before joints become painful, psoriatic arthritis (PsA) often begins silently as enthesitis—inflammation where tendons and ligaments attach to bone.

26 Jun 2026

Opposing protein pathways control skin regeneration and disease development

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

25 Jun 2026

Most psoriasis patients can safely reduce their dosage of biologics

Three-quarters of people who respond well to the newest types of biologics for psoriasis can safely reduce their dosage, often even by half.

1 Jun 2026

Gene mapping highlights strong immune and brain connections in depression

Neurons and white blood cells differ greatly in shape, function, and location within the body. However, researchers at the University of São Paulo (USP) in Brazil discovered that certain genes are equally dysregulated in both cell types in people with depression.

11 May 2026

Largest blood protein genetics study reveals new precision medicine opportunities

Involving a collaboration with 118 investigators contributing from 89 institutions, scientists from Queen Mary University of London's Precision Healthcare University Research Institute and Berlin Institute of Health (BIH) at Charité have led the world's largest study on the genetic regulation of blood proteins.

6 May 2026

Lab-grown skin organoids provide new insights into blood vessel pathology

New research has shown that single blood vessel cells that appear in the earliest stages of lab-grown skin organoids have the ability to form complex microvascular networks that grow and mature over time.

28 Apr 2026

Gut-derived metabolites regulate immune cells in complex ways

Published on March 23, 2026, in Volume 2, article number 18 of the journal Immunity & Inflammation, the review begins by systematically outlining the sources and synthetic pathways of immune-relevant microbial metabolites, including bile acids, short-chain fatty acids, amino acid derivatives, vitamins, trimethylamine/trimethylamine N-oxide, and odd-chain fatty acids.

31 Mar 2026

Short bursts of vigorous activity can lower risk of major diseases

People who get just a few minutes of vigorous activity daily are less likely to develop eight major diseases, including arthritis, heart disease and dementia, according to research published in the European Heart Journal today (Monday).

29 Mar 2026

New skin atlas maps over one million cells across the human body

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body.

25 Mar 2026

Non-invasive immune monitoring via bandage-like microneedle patches

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin.

2 Mar 2026

Skin of color seminar improves medical students’ diagnosis skills

A seminar improved medical students' ability to identify skin conditions in darker skin tones, addressing diagnostic gaps in diverse patient populations.

23 Feb 2026

Ion channel TRPV4 found to regulate relief after scratching an itch

When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels "enough," is not accidental.

22 Feb 2026

Pigs and grizzly bears may reveal secrets of youthful skin

The secret to youthful appearance and repairing scars may lie in a microscopic skin structure humans share with pigs and grizzly bears - but, surprisingly, not monkeys.

4 Feb 2026

First topical CRISPR gene therapy corrects disease-causing mutations in human skin

Gene-editing tools like CRISPR have unlocked new treatments for previously uncurable diseases. Now, researchers at the University of British Columbia are extending those possibilities to the skin for the first time.

27 Jan 2026

Understanding how the immune system protects against fungal pathogenicity

The yeast Candida albicans colonizes mucosal surfaces and is usually harmless. However, under certain conditions it can cause dangerous infections.

15 Dec 2025

Psoriasis caused by changes in the fat metabolism of skin cells

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis - and at the same time represents a potential biomarker for a new treatment concept.

11 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Study links endocrine-disrupting chemicals to hidradenitis suppurativa

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

1 Dec 2025

Study develops highly accurate polygenic risk models tailored for Han Chinese populations

Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such as diabetes, heart disease, autoimmune disorders.

20 Nov 2025