T Cell News and Research

Latest T Cell News and Research

Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and that plaques were reduced and cognitive performance improved when this action was prevented in mice through loss of the enzyme GnT-III.

17 Jan 2015

Study: Stem cells derived from human female amnion have anti-inflammatory effects

Stem cells derived from human amnion have for some time been considered promising for cell therapies because of their ease of access, ability to differentiate, and absence of ethical issues.

17 Jan 2015

Researchers gain new insight into fragile X syndrome

Scientists have gained new insight into fragile X syndrome -- the most common cause of inherited intellectual disability -- by studying the case of a person without the disorder, but with two of its classic symptoms.

17 Jan 2015

CUMC researchers identify that OCR stem cells can regenerate bone and cartilage in mice

A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The discovery by researchers at Columbia University Medical Center is reported today in the online issue of the journal Cell.

16 Jan 2015

$New device holds promise for improving the delivery of stem cell therapy for non-healing fractures$

New device holds promise for improving the delivery of stem cell therapy for non-healing fractures

A new device that can rapidly concentrate and extract young cells from irrigation fluid used during orthopaedic surgery holds promise for improving the delivery of stem cell therapy in cases of non-healing fractures. UC Davis surgeons plan to launch a "proof-of-concept" clinical trial to test the safety and efficacy of the device in the coming months.

16 Jan 2015

Findings may lead to novel therapeutic approaches to prevent fibrosis in Crohn's disease patients

A natural protein made by immune cells may limit fibrosis and scarring in colitis, according to research published in the inaugural issue of Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.

16 Jan 2015

New research sheds light on the role of Sox10 protein in Hirschsprung's disease patients

Defects in the protein Sox10, a transcription factor that regulates gene expression, may play a role in the development of post-operative GI dysfunction in Hirschsprung's disease patients, according to new research published in Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.

16 Jan 2015

CNIO researchers identify new mechanism that influences differentiation of keratinocytes

The formation of human skin involves a cascade of biochemical signals, which are not well understood. However, they are very important since their failure may cause diseases, such as Atopic Dermatitis and skin cancers, which affect more than 25% of the human population.

16 Jan 2015

PTEN protein helps prevent autoimmune diseases

St. Jude Children's Research Hospital scientists have discovered that a protein widely known for suppressing tumor formation also helps prevent autoimmune diseases and other problems by putting the brakes on the immune response.

15 Jan 2015

UH Case Medical Center researchers find that coenzyme A plays key role in cell metabolism

Case Western Reserve and University Hospitals Case Medical Center researchers and physicians have discovered that the molecule known as coenzyme A plays a key role in cell metabolism by regulating the actions of nitric oxide. Cell metabolism is the ongoing process of chemical transformations within the body's cells that sustains life, and alterations in metabolism are a common cause of human disease, including cancer and heart disease.

15 Jan 2015

BellBrook Labs announces launch of new Transcreener UDP TR-FRET Assay

BellBrook Labs, a leader in high throughput screening assays for drug discovery, announced the launch of a TR-FRET (time resolved Forster resonance energy transfer) version of the company's Transcreener UDP Assay, a high throughput screening assay for glycosyltransferases and other UDP-producing enzymes.

15 Jan 2015

CAR T-cell therapy enters into Phase I clinical trial

Cancer fighting chimeric antigen receptor (CAR) T cells, developed in the Sentman laboratory of Dartmouth's Norris Cotton Cancer Center, are taking the next step into a Phase I clinical trial beginning early in 2015.

15 Jan 2015

People with iron overload disease are more vulnerable to Vibrio vulnificus infections

Every summer, the news reports on a bacterium called Vibrio vulnificus found in warm saltwater that causes people to get sick, or die, after they eat raw tainted shellfish or when an open wound comes in contact with seawater.

15 Jan 2015

TSRI scientists identify novel synthetic compound that reduces activity of a cancer-related protein

Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers.

15 Jan 2015

Lung cancer rates are lower in higher-elevation counties, new study finds

Here's another potential reason to live up in the mountains. Lung cancer rates in both smokers and non-smokers are lower in higher-elevation counties in the western part of the United States, suggesting that oxygen may promote the incidence of lung cancer, according to a new study co-authored by a student at the Perelman School of Medicine at the University of Pennsylvania.

15 Jan 2015

Platelet transfusion treatment increases death in people with certain rare blood cell disorders

People hospitalized with certain rare blood cell disorders frequently receive a treatment that is associated with a two- to fivefold increase in death, according to a new study that reviewed hospital records nationwide. The study authors recommend that for these rare disorders, doctors should administer the treatment, a platelet transfusion, only in exceptional circumstances.

14 Jan 2015

Urinary levels of novel biomarkers linked to adverse long-term outcomes in AKI patients

High levels of two novel urinary biomarkers early in critical illness are associated with adverse long-term outcomes in patients with acute kidney injury (AKI), according to an international, multi-center study led by University of Pittsburgh School of Medicine Researchers.

14 Jan 2015

TERT mutations may make smokers more susceptible to emphysema

Mutations in a gene that helps repair damaged chromosome ends may make smokers — especially female smokers — more susceptible to emphysema, according to results of a new study led by Johns Hopkins Kimmel Cancer Center researchers.

14 Jan 2015

PharmaMar to begin PM1183 Phase III trial in combination with doxorubicin in SCLC

Zeltia announces today that its pharmaceutical division PharmaMar will start a Phase III trial with PM1183 in combination with doxorubicin against topotecan in SCLC, given the activity observed in an interim analysis of an ongoing Phase Ib trial. The results of this study will be presented at a prominent international cancer meeting this year, which will be soon announced.

14 Jan 2015

Researchers identify new target that could lead to potential therapies for GBM

Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute for Molecular Medicine have identified a new protein-protein interaction that could serve as a target for future therapies for the most common form of brain cancer, glioblastoma multiforme (GBM).

14 Jan 2015

T Cell News and Research

Latest T Cell News and Research

Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Study: Stem cells derived from human female amnion have anti-inflammatory effects

Researchers gain new insight into fragile X syndrome

CUMC researchers identify that OCR stem cells can regenerate bone and cartilage in mice

New device holds promise for improving the delivery of stem cell therapy for non-healing fractures

Findings may lead to novel therapeutic approaches to prevent fibrosis in Crohn's disease patients

New research sheds light on the role of Sox10 protein in Hirschsprung's disease patients

CNIO researchers identify new mechanism that influences differentiation of keratinocytes

PTEN protein helps prevent autoimmune diseases

UH Case Medical Center researchers find that coenzyme A plays key role in cell metabolism

BellBrook Labs announces launch of new Transcreener UDP TR-FRET Assay

CAR T-cell therapy enters into Phase I clinical trial

People with iron overload disease are more vulnerable to Vibrio vulnificus infections

TSRI scientists identify novel synthetic compound that reduces activity of a cancer-related protein

Lung cancer rates are lower in higher-elevation counties, new study finds

Platelet transfusion treatment increases death in people with certain rare blood cell disorders

Urinary levels of novel biomarkers linked to adverse long-term outcomes in AKI patients

TERT mutations may make smokers more susceptible to emphysema

PharmaMar to begin PM1183 Phase III trial in combination with doxorubicin in SCLC

Researchers identify new target that could lead to potential therapies for GBM

Immunology eBook

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PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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