T Cell News and Research

Latest T Cell News and Research

Cell receptor recycling mechanism discovery opens up new class of therapeutic targets

Prof. Manojkumar Puthenveedu of Carnegie Mellon University studies the mechanisms by which membrane trafficking controls and co-ordinates the complex signalling pathways in the brain. Despite the fact that almost all diseases can be traced to a defect in how cells respond to signals, little is known about how signalling pathways are maintained in normal cells and the changes that occur in abnormal conditions.

23 Mar 2011

Contrast agent for tumor diagnostics

X-rays are not the only way: visible and especially infrared light can also be used to image human tissue. The effectiveness of optical imaging processes can be significantly improved with suitable dyes used as contrast agents. In the journal Angewandte Chemie, a team led by Wenbin Lin at the University of North Carolina (Chapel Hill, USA) has now introduced a novel contrast agent that marks tumor cells in vitro. The dye is a phosphorescent ruthenium complex incorporated into nanoparticles of a metal–organic coordination polymer, which allows an extraordinarily high level of dye loading.

23 Mar 2011

New insights into cancer genome may lead to designer drugs for myeloma

Patients with myeloma could benefit from ‘designer’ drugs in the future after new genome-mapping technology has allowed scientists to identify a full genetic blueprint of the mutations which drive the bone marrow cancer.

23 Mar 2011

NephRx receives new U.S. patent for NX002 to treat oral mucositis

NephRx Corporation today announced issuance of a new U.S. patent for its novel peptide NX002, which currently is in preclinical development for the treatment of oral mucositis.

23 Mar 2011

Study finds novel physical mechanism behind cancer migration

Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited.

23 Mar 2011

Researchers create nanosurfaces to seal leg prosthetics against bacteria entry

In recent years, researchers have worked to develop more flexible, functional prosthetics for soldiers returning home from battlefields in Afghanistan or Iraq with missing arms or legs. But even new prosthetics have trouble keeping bacteria from entering the body through the space where the device has been implanted.

23 Mar 2011

MnSOD oral drug can protect against lung cancer radiation therapy

Patients with advanced non-small cell lung cancer can safely take an experimental oral drug intended to protect healthy tissue from the effects of radiation, according to a study led by researchers at the University of Pittsburgh Cancer Institute and published in this month's issue of Human Gene Therapy.

23 Mar 2011

Clinical trial to evaluate efficacy of PRP for osteoarthritis pain treatment

For years, doctors have used platelet-rich plasma, or PRP, to promote healing after surgery. Now, Rush University Medical Center is studying whether PRP can help relieve knee pain in patients with mild to moderate osteoarthritis.

23 Mar 2011

Biologists decipher molecular code regulating availability of brain channel linked to neuronal excitability

A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing channel protein activity can alter an organism's behavior.

23 Mar 2011

AHA to honor BIDMC investigator for groundbreaking Vascular Biology research

Alterations in blood vessel dilation lie at the heart of coronary artery health: When vessels dilate, blood and oxygen supplies successfully reach the heart. When vessels contract, blood and oxygen are diminished, leading to coronary artery disease.

23 Mar 2011

Obese teens have inflammation, insulin resistance, and high homocysteine levels despite feeling healthy

Obese teens may feel healthy, but blood tests show they have inflammation, insulin resistance, and high homocysteine levels, researchers report at the American Heart Association's Nutrition, Physical Activity and Metabolism/Cardiovascular Disease Epidemiology and Prevention 2011 Scientific Sessions.

23 Mar 2011

Medical oncologist to receive AACR award for breast cancer research

Vassiliki Karantza, MD, PhD, a medical oncologist at The Cancer Institute of New Jersey will be honored with the Genentech BioOncology Career Development Award sponsored by the American Association for Cancer Research at the Association's 102nd Annual Meeting taking place April 2 through 6 in Orlando.

23 Mar 2011

FDA approves Harvest's BMAC System IDE trial to treat non-reconstructable Critical Limb Ischemia

Harvest Technologies Corp. announced today that the FDA has approved the company sponsored 210-patient IDE clinical trial to be conducted at twenty-five sites in the U.S. using the company's proprietary Bone Marrow Aspiration Concentrate (BMAC) System to treat patients with non-reconstructable Critical Limb Ischemia (CLI).

23 Mar 2011

Researchers discover novel gene regulation mechanism that contributes to HCC development

Researchers at Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine have discovered a novel mechanism in gene regulation that contributes to the development of a form of liver cancer called hepatocellular carcinoma.

23 Mar 2011

Cellerant commences CLT-008 Phase I/II trial in patients with leukemia

Cellerant Therapeutics Inc., a biotechnology company developing novel hematopoietic stem cell-based cellular and antibody therapies for blood disorders and cancer, announced the initiation of a Phase I/II clinical trial of CLT-008 in patients receiving intensive post-remission chemotherapy for high-risk leukemia or myelodysplasia.

23 Mar 2011

SGEN, Abbott enter collaboration agreement for ADC products

Seattle Genetics, Inc.today announced that it has entered into a collaboration agreement with Abbott under which Abbott will pay an upfront fee of $8 million for rights to utilize Seattle Genetics' antibody-drug conjugate technology with antibodies to a single oncology target.

23 Mar 2011

AstraZeneca, Senectus sign deal to identify compounds that trigger cancer cell ageing

Senectus Therapeutics has signed a deal to screen a selection of AstraZeneca's chemical compound library to identify those which trigger a key element of cancer cell ageing - called senescence.

23 Mar 2011

Shire's Replagal and VPRIV data on Gaucher and Fabry patients presented at ACMG meeting

Shire plc, the global specialty biopharmaceutical company, presented new data for Replagal in patients with Fabry disease, and VPRIV in patients with type 1 Gaucher disease, at the 2011 American College of Medical Genetics' Annual Clinical Genetics Meeting, held in Vancouver, BC, from March 16-20, 2011.

22 Mar 2011

WHO concerned about radiation levels in food near damaged Japanese nuclear plant

A WHO spokesperson "said on Monday that the detection of radiation in food after an earthquake damaged a Japanese nuclear plant was a more serious problem than had first expected," Reuters reports.

22 Mar 2011

Researcher to look for genes that can suppress epileptic seizures in fruit flies

"Exceptional, Unconventional Research Enabling Knowledge Acceleration" - is the name of a rare and competitive grant that Reenan recently won from the National Institutes of Health. Beginning April 1, Reenan will use the four-year, $1.3-million award to look for genes that can suppress seizures in fruit flies that he has cleverly engineered to mimic human epilepsy.

22 Mar 2011

T Cell News and Research

Latest T Cell News and Research

Cell receptor recycling mechanism discovery opens up new class of therapeutic targets

Contrast agent for tumor diagnostics

New insights into cancer genome may lead to designer drugs for myeloma

NephRx receives new U.S. patent for NX002 to treat oral mucositis

Study finds novel physical mechanism behind cancer migration

Researchers create nanosurfaces to seal leg prosthetics against bacteria entry

MnSOD oral drug can protect against lung cancer radiation therapy

Clinical trial to evaluate efficacy of PRP for osteoarthritis pain treatment

Biologists decipher molecular code regulating availability of brain channel linked to neuronal excitability

AHA to honor BIDMC investigator for groundbreaking Vascular Biology research

Obese teens have inflammation, insulin resistance, and high homocysteine levels despite feeling healthy

Medical oncologist to receive AACR award for breast cancer research

FDA approves Harvest's BMAC System IDE trial to treat non-reconstructable Critical Limb Ischemia

Researchers discover novel gene regulation mechanism that contributes to HCC development

Cellerant commences CLT-008 Phase I/II trial in patients with leukemia

SGEN, Abbott enter collaboration agreement for ADC products

AstraZeneca, Senectus sign deal to identify compounds that trigger cancer cell ageing

Shire's Replagal and VPRIV data on Gaucher and Fabry patients presented at ACMG meeting

WHO concerned about radiation levels in food near damaged Japanese nuclear plant

Researcher to look for genes that can suppress epileptic seizures in fruit flies

Immunology eBook

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

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