Telomere News and Research

Latest Telomere News and Research

Researchers target telomeres to attack tumors

Hoping to develop more effective long-term attacks on cancer, researchers at the Indiana University School of Medicine are conducting the first human tests of a breast cancer drug regimen that includes a compound meant to force cancer cells to grow old and die.

5 May 2009

African sleeping sickness parasite breaks its own DNA to avoid detection

The parasite Trypanosoma brucei, which causes African sleeping sickness, is like a thief donning a disguise.

15 Apr 2009

The egg makes sure that sperm don't get too old

In contrast to women, men are fertile throughout life, but research at the Sahlgrenska Academy, University of Gothenburg, Sweden, has now shown that a fertilising sperm can get help from the egg to rejuvenate. The result is an important step towards future stem cell therapy.

25 Mar 2009

Study reinforces the importance of healthy living for women

Women who maintain a healthy weight and who have lower perceived stress may be less likely to have chromosome changes associated with aging than obese and stressed women, according to a pilot study that was part of the Sister Study.

16 Mar 2009

Enhanced skin cancer risk linked to defects in cellular aging controls

Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied.

23 Feb 2009

Researchers find link between two aging pathways in mice

Two previously identified pathways associated with aging in mice are connected, say researchers at the Stanford University School of Medicine.

9 Jan 2009

Researchers identify gene linked to inherited form of fatal lung disease

Researchers at UT Southwestern Medical Center have determined that a mutation in a gene known for its role in defending the lungs against invading pathogens is responsible for some inherited cases of a lethal lung disease affecting older adults. The same mutation may also be associated with lung cancer, the researchers said.

21 Dec 2008

Astragalus root plant chemical used to fight HIV

Like other kinds of cells, immune cells lose the ability to divide as they age because a part of their chromosomes known as a telomere becomes progressively shorter with cell division.

11 Nov 2008

Scientists discover how a well-known protein repairs broken DNA ends

During the life cycle of our cells, a minefield of environmental and biological assaults can lead to double-stranded DNA breaks, the most lethal and dangerous form of DNA damage. Now, in research published online this week in Nature, Rockefeller University scientists reveal that when these breaks occur, a protein called 53BP1 helps repair them by mobilizing their dangly DNA ends - findings that uncover a previously unknown aspect of how double-stranded breaks can get fixed.

26 Oct 2008

Sea birds' DNA may hold keys to aging and cancer, Bucknell researcher says

Chances are, a mouse in the wild will live less than a year before stumbling upon a hungry falcon or feline.

5 Oct 2008

Discovery of tumour growth enzyme could lead to new cancer drugs

Scientists say a landmark study has revealed an enzyme which is vital to the growth of many cancers.

1 Sep 2008

Scientists identify possible cause of endometriosis

Scientists at the University of Liverpool have identified an enzyme that could be responsible for a condition called endometriosis - the most common cause of pelvic pain in women.

5 Aug 2008

Eroded telomeres are behind dyskeratosis congentia aging syndrome

Each time a cell divides, the protective caps at the ends of chromosomes shorten - and when these caps are gone, so are we. Now, by using an unconventional strategy to shorten telomeres in mice, researchers at Rockefeller University have not only created the first faithful mouse model for studying a rare yet fatal premature aging syndrome, but they have revealed the molecular defect behind the disease.

30 Jul 2008

UGA discovery could lead to new ways to attack cancers by blocking their ability to grow

Human cancer cells divide and conquer. Unless physicians can control that division with surgery, chemotherapy or radiation, the wildly dividing cells will eventually destroy a person's life.

10 Jul 2008

Length of telomeres in blood cells tied to breast cancer survival rates

Researchers at Umea University in Sweden have shown that the length of telomeres in blood cells in newly diagnosed breast cancer patients is tied to survival rates. The study, published in the journal Cancer Research, was carried out by a research team headed by Professor Goran Roos at the Department of Medical Bioscience, Pathology.

15 May 2008

Researchers find way to make tumor cells more sensitive to hyperthermia-enhanced radiation therapy

Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers at Washington University School of Medicine in St. Louis report.

6 May 2008

Stanford researchers unmask proteins in telomerase

One of the more intriguing workhorses of the cell, a protein conglomerate called telomerase, has in its short history been implicated in some critical areas of medicine including cancer, aging and keeping stem cells healthy.

24 Mar 2008

Scientists identifiy elusive telomere RNA subunit in single cell model

The Stowers Institute's Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model.

28 Dec 2007

Telomerase enzyme structure provides significant new target for anti-cancer therapies

Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Since the mid-1990s, when telomerase was first identified in human tumors, scientists have eyed the enzyme as an ideal target for developing broadly effective anti-cancer drugs.

14 Nov 2007

Possible biomarker for colon cancer in people under 50

An abnormality of chromosomes long associated with diseases of aging has, for the first time, been linked to colon cancer in people 50 years old and younger, an age group usually considered young for this disease.

28 Oct 2007