Thrombosis News and Research

Latest Thrombosis News and Research

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), is associated with several clinical features common in autoimmune diseases as myalgias, arthralgias, fatigue, and rashes. COVID-19 patients also exhibit less common autoimmunity manifestations such as myositis, thrombosis, myocarditis, encephalitis, vasculitis, and arthritis.

1 Feb 2021

Scientists engineer potent trivalent inhibitors of thrombin

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient.

29 Jan 2021

Common anticoagulant drug could be repurposed to help alleviate Covid-19 infections

An international team of researchers led by the Universities of Keele and Liverpool, working with Public Health England, has found that the common anticoagulant drug heparin inhibits the SARS-Cov2virus spike protein, by reducing the virus' ability to attach to human cells and infect them.

28 Jan 2021

'Post-acute COVID-19 syndrome' likely to substantially impact NHS in England

Researchers in the UK have warned that cardiometabolic and pulmonary events among coronavirus disease 2019 (COVID-19) survivors following their discharge from hospital is likely to have an ongoing and substantial impact on the National Health Service (NHS) in England.

26 Jan 2021

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

With the emergence of COVID-19 (coronavirus disease 2019), researchers have been closely investigating the complex interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the human immune system, and COVID-19 disease severity.

25 Jan 2021

Blood group associated with cardiovascular events in COVID-19 patients

An illuminating new study by scientists at Harvard Medical School, USA, describes the correlation of such conditions with the ABO blood group. The team's findings may help assess the risk of COVID-19 patients for such complications, promoting early diagnosis and underscoring potential needs for preventive and therapeutic care where possible.

21 Jan 2021

ACE2 and furin levels linked to inflammation in smokers with COVID-19

A new study reports the level of ACE2 and furin, two enzymes that are intimately linked to infection with SARS-CoV-2, the causative agent of COVID-19.

21 Jan 2021

Kruppel-like factor 2 may be a major determinant of acute respiratory distress syndrome in COVID-19 patients

A study conducted at the University of Chicago, USA, has recently revealed that downregulation of an endothelial transcription factor, Kruppel-like factor 2, by SARS-CoV-2 is responsible for ARDS frequently observed in critically ill COVID-19 patients.

19 Jan 2021

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

A team of scientists from the United States and Sweden has recently demonstrated that increased levels of a proinflammatory cytokine, angiopoietin-2, is responsible for hypercoagulation observed in severe COVID-19 patients.

18 Jan 2021

LSU Health receives $2.5 million grant to reduce stroke risk for obese women taking birth control pills

The National Heart, Lung, and Blood Institute of the National Institutes of Health has awarded Rinku Majumder, PhD, Associate Professor of Biochemistry & Molecular Biology at LSU Health New Orleans School of Medicine, a $2.5 million grant over four years to help reduce the high stroke risk to women with obesity who take estrogen-containing birth control pills.

14 Jan 2021

COVID-19 survivors can show persistent symptoms six months after recovery, study finds

A team of researchers conduct a large study exploring the persistence of COVID-19 symptoms in recovered patients.

13 Jan 2021

Could fenofibrate be an effective antiviral against SARS-CoV-2?

The resurgence of COVID-19 pandemic, caused by the SARS-CoV-2, has led to renewed efforts to find effective antivirals, both newly developed or repurposed drugs. A study reports the efficacy of the cholesterol-reducing drug fenofibrate in reducing infection rates of SARS-CoV-2 in cultured cells.

13 Jan 2021

New clinical practice guidelines on diagnosis, management of von Willebrand Disease

The American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH) have developed joint clinical practice guidelines on the diagnosis and management of von Willebrand Disease (VWD), the world's most common inherited bleeding disorder. The guidelines were published today in Blood Advances.

13 Jan 2021

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy.

12 Jan 2021

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

A recent study conducted by scientists from the Yokohama City University, Japan, has revealed that elevated alveolar endothelial injury markers in coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome (ARDS) are the main causative factors for alveolar barrier disruption. In COVID-19 patients with ARDS, endothelial injury persists for a longer time than epithelial injury.

12 Jan 2021

Gut and oral microbiomes predict COVID-19 severity

One question that continues to remain unanswered during the ongoing coronavirus disease 2019 (COVID-19) pandemic has been why is there a distinctive hit-and-miss pattern when it comes to severe disease? An interesting new study that appears on the medRxiv* preprint server pinpoints one highly relevant risk factor: the state of the oral and gut microbiomes.

7 Jan 2021

Engineered nanodroplets and ultrasound 'drill' can help eliminate tough blood clots

Engineering researchers have developed a new technique for eliminating particularly tough blood clots, using engineered nanodroplets and an ultrasound "drill" to break up the clots from the inside out.

7 Jan 2021

FDA authorizes first device to treat patients with walled-off pancreatic necrosis

Today, the U.S. Food and Drug Administration authorized marketing of the EndoRotor System to resect (cut out) and remove necrotic (dead) tissue for patients with walled-off pancreatic necrosis (WOPN), a potentially deadly condition which can occur several weeks after an episode of severe acute pancreatitis, often requiring tissue removal.

23 Dec 2020

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

Top-line data from the 270-patient global Phase 2/3 COVID-19 study expected Q1/2021. Top-line data from the 40-patient U.S. Phase 2 study of opaganib in severe COVID-19 expected in the coming days; this non-powered study was designed to evaluate safety and potential identification of preliminary efficacy signals in support of the global Phase 2/3 study of opaganib.

23 Dec 2020

New toolkit aims to maximize high-quality collection of thrombosis data in COVID-19 clinical studies

The ASH Research Collaborative and the International Society of Haemostasis and Thrombosis, two organizations with multidisciplinary expertise in blood clotting and bleeding disorders, have developed a toolkit to help clinical researchers from across medical disciplines design clinical trials that further the understanding of blood clotting events associated with COVID-19.

17 Dec 2020

Thrombosis News and Research

Latest Thrombosis News and Research

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Scientists engineer potent trivalent inhibitors of thrombin

Common anticoagulant drug could be repurposed to help alleviate Covid-19 infections

'Post-acute COVID-19 syndrome' likely to substantially impact NHS in England

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

Blood group associated with cardiovascular events in COVID-19 patients

ACE2 and furin levels linked to inflammation in smokers with COVID-19

Kruppel-like factor 2 may be a major determinant of acute respiratory distress syndrome in COVID-19 patients

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

LSU Health receives $2.5 million grant to reduce stroke risk for obese women taking birth control pills

COVID-19 survivors can show persistent symptoms six months after recovery, study finds

Could fenofibrate be an effective antiviral against SARS-CoV-2?

New clinical practice guidelines on diagnosis, management of von Willebrand Disease

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

Gut and oral microbiomes predict COVID-19 severity

Engineered nanodroplets and ultrasound 'drill' can help eliminate tough blood clots

FDA authorizes first device to treat patients with walled-off pancreatic necrosis

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

New toolkit aims to maximize high-quality collection of thrombosis data in COVID-19 clinical studies

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Thrombosis News and Research

Latest Thrombosis News and Research

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Newsletters you may be interested in