Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about PERISYL.
It does not contain all the available information. It does not take the place of
talking to your doctor or pharmacist.
All medicines have benefits and risks. Your doctor has weighed the risks of you taking
PERISYL against the benefits expected for you.
If you have any concerns about taking this medicine, talk to your doctor or pharmacist.
Keep this leaflet with your medicine.
You may need to read it again.
What PERISYL is used for
The active ingredient of PERISYL, perindopril belongs to a group of medicines called
Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors).
PERISYL is available only with a doctor's prescription.
PERISYL lowers high blood pressure, a condition which doctors call hypertension.
Everyone has blood pressure. This pressure helps get your blood all around the body.
Your blood pressure may be different at different times of the day, depending on how
busy or worried you are. You have high blood pressure when your blood pressure stays
higher than is needed, even when you are calm or relaxed.
There are usually no symptoms of high blood pressure. The only way of knowing that
you have it is to have your blood pressure checked on a regular basis. If high blood
pressure is not treated it can lead to serious health problems. You may feel fine
and have no symptoms, but eventually it can cause stroke, heart disease and kidney
PERISYL helps lower your blood pressure.
You may be prescribed PERISYL for heart failure.
Heart failure means that the heart muscle cannot pump blood strongly enough to supply
all the blood needed throughout the body. Heart failure is not the same as heart attack
and does not mean that the heart stops working. Some people develop heart failure
after having had a heart attack. However there are also other causes of heart failure.
Heart failure may start off with no symptoms, but as the condition progresses, you
may feel short of breath or may get tired easily after light physical activity such
as walking. You may wake up short of breath at night. Fluid may collect in different
parts of the body, often first noticed as swollen ankles and feet. In severe heart
failure, symptoms may occur even at rest.
PERISYL helps to treat heart failure. If you follow your doctor's advice, your ability
to perform daily activities may improve. You may breathe more easily, feel less tired,
and have less swelling.
You may also have been prescribed PERISYL if you have coronary artery disease.
Coronary artery disease is narrowing of the vessels carrying blood to the heart. In
patients with coronary artery disease, PERISYL has been shown to reduce some of the
risks, including heart attacks.
Before you take PERISYL
There are some people who shouldn't take PERISYL. Please read the list below. If you
think any of these situations apply to you or you have any questions, please consult
Do not take PERISYL if:
you are allergic to perindopril, any other ACE inhibitor or any of the ingredients
listed at the end of this leaflet
you have experienced symptoms such as wheezing, swelling of the face, tongue, lips
or throat, intense itching or severe skin rashes with previous ACE inhibitor treatment
or if you or a member of your family have had these symptoms either spontaneously
or, in response to another medicine in the past (a rare condition called angioedema)
you are pregnant or plan to become pregnant
you are breastfeeding or plan to breastfeed
you undergo treatments where your blood is treated outside of the body (also known
as extracorporeal treatments) that may increase your risk of allergic reactions, treatments
renal dialysis or haemofiltration using polyacrylonitrile membranes
low-density lipoprotein (LDL) apheresis, a technique where LDL is 'filtered' out of
the blood, using dextran sulfate
you are treated with a blood pressure lowering medicine containing aliskiren and have
diabetes or impaired kidney function
you have kidney problems where the blood supply to your kidneys is reduced (renal
you are treated with sacubitril/ valsartan a medicine used to treat long-term heart
failure as the risk of angioedema (rapid swelling under the skin in an area such as
the throat) is increased (see also 'Tell Your Doctor Straight Away' and 'Taking Other
the packaging is damaged or shows signs of tampering
The expiry date (EXP) on the pack has passed.
Tell your doctor straight away if:
you are pregnant or become pregnant while taking PERISYL, as it may cause serious
harm to your baby.
you are undergoing desensitisation treatment, or have had an allergic reaction during
previous desensitisation treatment (e.g. treatments using bee, wasp or ant venom).
you are undergoing, or you are intending to undergo, treatments where your blood is
treated outside of the body (also known as extracorporeal treatments).
you are to undergo anaesthesia and/or surgery.
you have recently suffered from diarrhoea or vomiting or are dehydrated.
you are on a salt restricted diet or use salt substitutes which contain potassium.
you have an intolerance to some sugars as PERISYL contains lactose.
you are taking lithium (used to treat mania or depression).
you are taking any of the following medicines used to treat high blood pressure:
an 'angiotensin II receptor blocker' (also known as ARBs or sartans - for example
valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney
you have any other health problems, including:
kidney disease, or if you are on renal dialysis
aortic stenosis (narrowing of the main blood vessel leading from the heart)
high or low levels of potassium, or other problems with salt balance.
low blood pressure
heart disease, including hypertrophic cardiomyopathy (heart muscle disease)
systemic lupus erythematous or scleroderma (a disease affecting the skin, joints and
are of African origin since you may have a higher risk of angioedema and this medicine
is less effective in lowering your blood pressure
have abnormally increased levels of a hormone called aldosterone in your blood (primary
If you think any of these situations apply to you, or you have any doubts or questions
about taking PERISYL consult your doctor or pharmacist.
Taking other medicines
Taking PERISYL may change the effect of some medicines, and some medicines may affect
how well PERISYL works. You may need different amounts of your medication or to take
different medicines. The medicines that may interact with PERISYL include the following:
some medications used to treat high blood pressure (including angiotensin receptor
blockers), aliskiren (see also 'Do Not Take PERISYL If' and 'Tell Your Doctor Straight
Away' sections), diuretics (sometimes called "fluid" or "water" tablets because they
increase the amount of urine passed each day)
some treatments where your blood is treated outside of the body, also known as extracorporeal
treatments (see also 'Do Not Take PERISYL If' and 'Tell Your Doctor Straight Away'
some antibiotics and medicines used to treat infections
some anti-inflammatory drugs (including high dose aspirin, ibuprofen) for pain relief
medicines used to treat mood swings and some types of depression (lithium, tricyclic
potassium-sparing diuretics, sources of potassium, like potassium tablet and salt
substitutes containing potassium, other drugs which can increase potassium in your
body (such as heparin, a medicine used to thin blood to prevent clots; co-trimoxazole
also known as trimethoprim/sulfamethoxazole for infections caused by bacteria; and
ciclosporin, an immunosuppressant medicine used to prevent organ transplant rejection)
immunosuppressants (medicines which reduces the activity of the body's natural defences)
vasodilators including nitrates
medicines used to treat diabetes (tablets and insulin)
medicines which may affect the blood cells, such as allopurinol, procainamide
baclofen (a medicine used to treat muscle stiffness in diseases such as multiple sclerosis)
medicines used for the treatment of low blood pressure, shock or asthma [e.g. ephedrine,
noradrenaline or adrenaline (epinephrine)]
gold salts, especially with intravenous administration (used to treat symptoms of
medicines which may increase the risk of angioedema (a severe allergic reaction) such
mammalian target of rapamycin (mTOR) inhibitors used to avoid rejection of transplanted
organs (e.g. temsirolimus, sirolimus, everolimus)
sacubitril (available as fixed-dose combination with valsartan), used to treat long-term
heart failure (see also 'Do Not Take PERISYL If' and 'Tell Your Doctor Straight Away'
gliptins used to treat diabetes (e.g. linagliptin, saxagliptin, sitagliptin, vildagliptin,
It is a good idea to remind your doctor of all other medicines you take. Your doctor
and pharmacist have more information on medicines to be careful with or avoid while
For older people or children
PERISYL can generally be used safely by elderly people. However reduced kidney function
is often found in elderly people and in this case, the starting dose should always
be 2 mg.
PERISYL is not recommended for children.
How to take PERISYL
The dose of PERISYL you may need each day will be decided and adjusted by your doctor.
This will normally be 2 mg, 4 mg or 8 mg once daily for high blood pressure and for
people with coronary artery disease, and 2 mg to 4 mg once daily for heart failure.
Swallow the tablet(s) with water, preferably in the morning before a meal.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next
dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking your medicine
as you would normally.
Do not take a double dose to make up for the dose you missed.
How long to take it
PERISYL helps control your blood pressure, or heart failure or coronary artery disease
but does not cure it. Continue taking the tablets for as long as your doctor tells
If you take too much (overdose)
Taking too much PERISYL (an overdose) may cause low blood pressure (also known as
hypotension). The most likely effect in case of overdose is low blood pressure which
can make you feel dizzy or faint. If this happens, lying down with the legs elevated
can help. Other effects like sickness, cramps, sleepiness, confusion, kidney problems,
salt and water disturbances are possible.
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you
think that you or anyone else may have taken too much PERISYL. Do this even if there
are no signs of discomfort or poisoning.
You may need urgent medical attention.
While you are taking PERISYL
Things you must do
Take PERISYL exactly as your doctor has prescribed. Otherwise you may not get the
benefits from treatment. Tell all doctors, dentists and pharmacists who are involved
with your treatment that you are taking PERISYL.
Make sure you drink enough water during exercise and hot weather especially if you
sweat a lot. This will help you avoid any dizziness or light-headedness caused by
a sudden drop in blood pressure.
Tell your doctor straight away if you have excessive vomiting or diarrhoea while taking
Things you must not do
Do not give your medicine to anyone else, even if they have the same condition as
Do not take PERISYL to treat any other complaints unless your doctor tells you to.
Do not stop taking your medicine or change the dosage without checking with your doctor.
Do not stop taking your tablets because you are feeling better, unless advised by
Things to be careful of
Be careful driving or operating machinery until you know how PERISYL affects you.
This medicine may cause dizziness or weariness due to low blood pressure in some people,
particularly at the start of treatment or when PERISYL is taken with another blood
pressure lowering medicine. If you have any of these symptoms, do not drive, operate
machinery or do anything else that could be dangerous.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get
Standing up slowly, especially when you get up from bed or chairs, will help your
body get used to the change in position and blood pressure. If this problem continues
or gets worse, talk to your doctor.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking PERISYL.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not.
PERISYL helps most people with high blood pressure, heart failure or coronary artery
disease, but it may have unwanted side effects in a few people. While these side effects
when they occur are usually mild they can be serious.
Angioedema (a severe allergic reaction) has been reported in patients treated with
ACE inhibitors, including PERISYL. This may occur at any time during treatment. If
you develop such symptoms described below you should tell your doctor immediately
or go to the Accident and Emergency department at your nearest hospital. These side
effects are extremely rare but can become serious:
swelling of your extremities (limbs, hands or feet), lips, face, mouth, tongue or
a fast and irregular heartbeat
purple spots with occasional blisters on the front of your arms and legs and/or around
your neck and ears (a rare condition known as Stevens-Johnson Syndrome)
difficulty in breathing
severe blisters, skin rash, itching, erythema multiforme or other allergic reactions.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
Common (may affect up to 1 in 10 people) side effects can include:
cough, often described as dry and irritating, shortness of breath, discomfort on exertion
headache, dizziness, vertigo, pins and needles
changes in the rhythm or rate of the heartbeat, fast or irregular heartbeat
feeling tired, lethargic or weak
tinnitus (persistent noise in the ears), vision disturbances
hypotension, flushing, impaired peripheral circulation, vasculitis, nose bleeds
nausea, vomiting, taste disturbances, indigestion, diarrhoea, constipation, stomach
pain or discomfort
rash, pruritus (itching)
Uncommon (may affect up to 1 in 100 people) side effects can include:
high levels in the blood of potassium, urea and/or creatine, low sodium levels in
mood disturbance, sleep disturbances (difficulty sleeping, abnormal dreams), feeling
sleepy or drowsy, fainting
difficulty breathing or wheezing
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in
swallowing or breathing
increased sensitivity of the skin to sun, skin rash or inflammation of the skin often
including blisters that weep and become crusted
increase in some white blood cells
fever or high temperature
decreased blood sugar levels
aching muscles, muscle tenderness or weakness, not caused by exercise
generally feeling unwell
Rare (may affect up to 1 in 1,000 people) side effects can include:
elevation of bilirubin levels in the blood, increases in liver enzymes
worsening of psoriasis
problems with production or passing of urine.
concentrated urine (dark in colour), feel or are sick, have muscle cramps, confusion
and fits which may be due to inappropriate anti-diuretic hormone (ADH) secretion can
occur with ACE inhibitors. If you have these symptoms contact your doctor as soon
Very rare (may affect up to 1 in 10,000 people) side effects can include:
inflammation of the pancreas (pancreatitis)
runny or blocked nose, sneezing, facial pressure or pain
red, often itchy spots, similar to the rash of measles, which starts on the limbs
and sometimes on the face and the rest of the body
swelling of hands, ankles or feet
bleeding or bruising more easily than normal caused by a low blood platelet count,
frequent infections such as fever, severe chills, sore throat or mouth ulcers caused
by a lack of white blood cells, pancytopenia (a rare type of anaemia)
illnesses resulting from a lack of red blood cells
stroke, myocardial infarction, angina pectoris (a feeling of tightness, pressure or
heaviness in the chest)
changes in the rhythm or rate of the heartbeat
confusion or hallucinations.
Not known (frequency cannot be estimated from the data available):
discolouration, numbness and pain in fingers or toes (Raynaud’s phenomenon)
Consult your doctor, pharmacist or nurse if you experience any of these or notice
anything else that is making you feel unwell.
Do not be alarmed by this list of possible side effects. You may not experience any
of them. Other uncommon side effects have been reported and you should ask your doctor,
pharmacist or nurse if you want to know more.
After taking PERISYL
Keep your tablets in the pack until it is time to take them.
If you take the tablets out of the pack they may not keep well.
Keep your tablets in a cool dry place where the temperature stays below 25°C.
Do not store PERISYL or any other medicine in the bathroom or near a sink. Do not
leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
return any leftover tablets to your pharmacist for disposal.
What it looks like
PERISYL 2 mg
Green coloured mottled, round, biconvex tablets debossed with “PT” over “2” on one
side of the tablet & “M” on the other side. Available in blister packs of 30.
PERISYL 4 mg
Green coloured mottled, capsule shaped, biconvex tablets with side notch debossed
with “PT4” on one side of the tablet & “M” on the other side. Available in blister
packs of 30.
PERISYL 8 mg
Green coloured mottled, round, biconvex tablets debossed with “PT8” on one side of
the tablet & “M” on the other side. Available in blister packs of 30.
PERISYL contains 2 mg, 4 mg and 8 mg of perindopril erbumine as the active ingredient.
It also contains the following inactive ingredients:
colloidal anhydrous silica
chlorophyllin-copper complex aluminium lake
PERISYL is supplied in Australia by:
Alphapharm Pty Ltd trading as Viatris
Level 1, 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Phone: 1800 274 276
This leaflet was prepared in May 2022.
Australian registration numbers:
PERISYL 2 mg: AUST R 176516
PERISYL 4 mg: AUST R 176518
PERISYL 8 mg: AUST R 176517
PERISYL® is a Viatris company trade mark