What is Diabetic Nephropathy?

Diabetic nephropathy is the damage caused to the kidneys by diabetes mellitus. Around 50% of individuals with type 1 diabetes will develop nephropathy within 10 years of having the disease and around 20% of those with type 2 disease will develop it within 20 years.

The persistently high blood sugar that occurs in diabetes can eventually cause damage to various organs including the kidneys, eyes and heart.

Diabetic nephropathy usually has a silent onset, meaning it may not be detected until much of the kidney is damaged.


Some of the features of diabetic nephropathy include:

  • Raised level of the protein albumin in the urine. Damaged kidneys may let large molecules such as albumin pass though into the urine, causing urine levels of albumin to rise.
  • Raised blood levels of creatinine. Creatinine is normally filtered out from the body by the kidneys but if the kidneys are damaged, the blood levels of creatinine may be raised.
  • There may be other organ damage caused by diabetes such as heart disease or diabetic retinopathy (eye damage).


Without treatment, diabetic nephropathy may eventually leads to end stage renal disease.

In the initial stages of disease, diabetic nephropathy does not cause pathological damage to the kidneys and is reversible. If the condition progresses, the kidneys will start to become damaged and the gromerular filtration rate will decrease.

The extent of kidney damage can range from mild and symptomless, as in stage 2 disease, through to end stage renal disease which is characterized by a significantly lowered filtration rate causing a build up of waste products in the blood.

Individuals with disease that is this advanced eventually require dialysis or a kidney transplant to stay alive. These individuals may also have complications of kidney disease such as high blood pressure, heart disease, bone disease and anemia.


In the early stages of diabetic nephropathy, when the urine levels of albumin are raised, blood pressure medications such as ACE inhibitors may be used as they can reduce the protein leakage. In more advanced stages, treatment includes control of blood sugar and blood pressure as well as the correction of other factors that raise the risk of heart disease such as high blood cholesterol.

Further Reading

Last Updated: Jul 3, 2023

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2023, July 03). What is Diabetic Nephropathy?. News-Medical. Retrieved on June 14, 2024 from https://www.news-medical.net/health/What-is-Diabetic-Nephropathy.aspx.

  • MLA

    Mandal, Ananya. "What is Diabetic Nephropathy?". News-Medical. 14 June 2024. <https://www.news-medical.net/health/What-is-Diabetic-Nephropathy.aspx>.

  • Chicago

    Mandal, Ananya. "What is Diabetic Nephropathy?". News-Medical. https://www.news-medical.net/health/What-is-Diabetic-Nephropathy.aspx. (accessed June 14, 2024).

  • Harvard

    Mandal, Ananya. 2023. What is Diabetic Nephropathy?. News-Medical, viewed 14 June 2024, https://www.news-medical.net/health/What-is-Diabetic-Nephropathy.aspx.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Innovative therapeutic strategies for combating type 2 diabetes