What is Formoline L112?

Skip to

In today’s market many weight aid loss remedies are being advertised with only a few registered as medical devices. One popular, well-known and registered weight loss aid is called formoline L112.

Formoline L112 is a linear polysaccharide (chitosan) with a low molecular weight. It consists of a ß-1,4-polymer of D-glucosamine and N-acetyl-D-glucosamine, which are derived from shellfish. It is part of a subgroup of polyglucosamines and registered as a class III medical device in Germany.

The main effect of formoline L112 is to limit the absorption of dietary fat absorbed, aid weight loss and weight maintenance, and to lower high cholesterol levels in the blood.

The manufacturer recommends that persons desiring weight loss take 2 tablets twice daily for weight loss or 1 tablet twice daily for weight management. The pills are designed to be taken toward the end of the two highest fat meals of the day.

Effectiveness of formoline L112 for losing weight

Several studies have shown modest weight loss and cholesterol lowering with formoline L112 use.  One study showed that those taking formoline L112 for 25 weeks lost 1.8 kg more weight than those taking placebo.  However, the participants were not followed beyond this time frame to see if the weight loss persisted over time.

In the study by Cnubben in 2016, the fat absorption from the GI tract to the circulation and exposure to free fatty acids were reduced, which may benefit overweight persons.

A review from 2018 by Cornelli concluded that polyglucosamine L112 binds to lipids and effectively reduces omental fat mass.

3D Rendering Lipid Bi-Layer Cell Anatomy - Illustration Credit: Nathan Devery / Shutterstock
3D Rendering Lipid Bi-Layer Cell Anatomy - Illustration Credit: Nathan Devery / Shutterstock

Omental fat is one risk factor for type 2 diabetes and cardiovascular disease. Interestingly, that study has found that the bound fat was used as a fuel rather than being excreted through feces and therefore avoiding fatty stool. However, the manufacturer does note that the supplement may affect stool consistency.

In a 2018 meta-analysis, use of formoline L112 was associated with lower total cholesterol and triglyceride levels in half of studies reviewed. Body weight reductions were also reported, with higher achievements if formoline L112 was combined with calorie reduction and physical activity. The studies only reported side effects in 1% of participants.

Side effects of formoline L112

As formoline L112 has high fat binding characteristics, it can bind dietary fat as well as fat soluble active pharmaceutical ingredients such as hormones, oral contraceptives, anticoagulants and antiepileptic drugs as well as Vitamins A, D, E and K, which are also fat soluble. This can reduce the effectiveness of these. The manufacturer recommends waiting at least 4 hours between taking these drugs and formoline L112.

Digestive problems such as diarrhoea are the most commonly reported effects. Further side effects have not been reported.

Take home message

Formoline L112 appears to provide a modest improvement in weight loss compared to placebo when combined with physical activity and caloric restriction.

Whilst taking Formoline L112, the patients need to prevent that the effects of other fat-soluble drugs taken are not reduced. Long term studies of L112 were not conducted yet but would help to understand if the supplement can help to maintain weight or if the weight loss is only temporarily.

Sources

Further Reading

Last Updated: Feb 13, 2023

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Azizi, Maryam. (2023, February 13). What is Formoline L112?. News-Medical. Retrieved on October 13, 2024 from https://www.news-medical.net/health/What-is-Formoline-L112.aspx.

  • MLA

    Azizi, Maryam. "What is Formoline L112?". News-Medical. 13 October 2024. <https://www.news-medical.net/health/What-is-Formoline-L112.aspx>.

  • Chicago

    Azizi, Maryam. "What is Formoline L112?". News-Medical. https://www.news-medical.net/health/What-is-Formoline-L112.aspx. (accessed October 13, 2024).

  • Harvard

    Azizi, Maryam. 2023. What is Formoline L112?. News-Medical, viewed 13 October 2024, https://www.news-medical.net/health/What-is-Formoline-L112.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.