What is GABA?

Skip to:

Gamma-Aminobutyric acid, or γ-aminobutyric acid (GABA) is a neurotransmitter found in the brain. Its activity in the brain was clarified in 1957 when scientists reported that GABA produced inhibitory effects on the neurons of crayfish.

It is now widely known as the main inhibitory receptor in the human cortex, but in recent years it has become a widely available food supplement in both Europe and the United States. GABA is considered to be a ‘dietary supplement;’ as such, it can be sold without evidence to support its efficacy. GABA is widely distributed in nature.

GABA is an inhibitory neurotransmitter of the nervous system.  Image Credit: Molecular Arts / Shutterstock
GABA is an inhibitory neurotransmitter of the nervous system. Image Credit: Molecular Arts / Shutterstock

What are the role and distribution of GABA?

GABA is distributed unequally in the brain. Its inhibitory effects result from inhibition of neuronal activity and synaptic plasticity.  Although GABA's primary function is as a neurotransmitter, it has the structure of an amino acid and is therefore referred to as an amino acid neurotransmitter. GABA is produced as glutamine in the diet is converted first to glutamate, then to GABA by glutamic acid decarboxylase. In adult brains GABA is inhibitory, whereas in the embryonic brain it is a well-established excitatory transmitter that exerts region-specific roles according to the developmental stage of the embryo.

GABA receptors, agonists and modulators

Nearly half of all synapses of the brain express some kind of GABA receptor. GABAA receptors are widely but differentially distributed within the CNS and they can be activated by several GABA isosteres, which are compounds with the same number of atoms and electrons. There are 2 types of receptors that GABA can stimulate: GABAA and GABAB. GABAA receptors are ionotropic; on GABA binding, an associated ion channel that is permeable to the negatively charged chloride ions opens to hyperpolarize the membrane potential. This decreases the likelihood of the neuron firing an action potential.

GABAB receptors are metabotropic or G protein-coupled receptors. The predominant effect of GABAB stimulation is the opening of potassium channels. As with chloride, potassium influx results in hyperpolarization, which decreases likelihood that a neuron will fire an action potential.

GABAA also has allosteric binding sites for other substances referred to as GABA modulators. These are capable of increasing or decreasing the action of GABA; in its absence, they have no effect. Depending on their effect, they are classified as positive or negative allosteric modulators (PAMs and NAMs, respectively).

A prominent example of a class of GABAA receptor positive allosteric modulators is benzodiazepines. They facilitate the interaction between GABA and GABAA, therefore potentiating the GABA inhibitory effect. These types of drugs are commonly used is for sedative purposes.

Other positive modulators include barbiturates and alcohol. Negative modulators, by contrast, compete with the binding of a positive modulator at the same site. Flumazenil is one such example of a competitive antagonist; it is used to reverse benzodiazepine overdose.

Some drugs show off-target negative allosteric modulator effects. For example, fluoroquinolone antibiotics, antidepressants, and beta-lactam antibiotics can negatively modulate GABA. GABA agonists also produce the same effect as positive allosteric modulators; they culminate in the reduction of the neuronal signals in the user’s brain. GABA antagonists, in contrast, increase brain activity -- examples include gabazine or bicuculline.

GABA and the blood-brain barrier

Historically, GABA has been thought to be unable to cross the blood-brain barrier (BBB), which throws into question the efficacy of GABA supplements to alleviate anxiety or improved sleep amongst other positive effects. However, the evidence to support GABA’s permeability is conflicting. several studies are unable to show that GABA crosses the BBB whereas others demonstrate its ability to do so.

According to an article published in Frontiers in Psychology (2015), the mechanism behind GABA supplements are unclear and further work is needed to establish the behavioral effects of GABA. The authors speculate that there is insufficient evidence to rule out the possible effect. Moreover, studies that have used GABA mimetics that do not structurally reflect the GABA molecule and delivered GABA through mechanisms that do not reflect user administration. Most notably, the permeability of GABA to the BBB has been confined to rodents.

Despite conflicting evidence for its entry into the CNS, GABBA may still affect the brain through the enteric nervous system, which contains many GABA receptors. The efficacy of GABA supplements is therefore confined to anecdotal evidence.

References

  • Moss, F.J., Imoukhuede, P.I, Just, H. & Lester, H.A. TRANSPORTERS | GABA Transporters: Structure, Oligomerization, Trafficking, and Pharmacology Determine Neuronal Excitability, Encycolpedia of Basic Epilepsy Research. (2009) doi: 10.1016/B978-012373961-2.00116-8
  • Goetz, T., Wulf, P., and Wisden, W. GABAA Receptors: Molecular Biology, Cell Biology, and Pharmacology. Encyclopedia of Neuroscience. (2009) doi: 10.1016/B978-008045046-9.01236-5
  • Sigel, E. et al. Structure, Function, and Modulation of GABAA Receptors. JBC. (2012) doi: 10.1074/jbc.R112.386664
  • Kinnersley, A.M 7 Turano, F.J. Gamma Aminobutyric Acid (GABA) and Plant Responses to Stress. Critical Reviews in Plant Sciences. (2000) doi: 10.1080/07352680091139277
  • Owens, D.f. & Kriegstein, A.R. Is there more to gaba than synaptic inhibition? Nature (2002) doi:10.1038/nrn919

Further Reading

Last Updated: Jan 20, 2020

Hidaya Aliouche

Written by

Hidaya Aliouche

Hidaya is a science communications enthusiast who has recently graduated and is embarking on a career in the science and medical copywriting. She has a B.Sc. in Biochemistry from The University of Manchester. She is passionate about writing and is particularly interested in microbiology, immunology, and biochemistry.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Aliouche, Hidaya. (2020, January 20). What is GABA?. News-Medical. Retrieved on October 27, 2020 from https://www.news-medical.net/health/What-is-GABA.aspx.

  • MLA

    Aliouche, Hidaya. "What is GABA?". News-Medical. 27 October 2020. <https://www.news-medical.net/health/What-is-GABA.aspx>.

  • Chicago

    Aliouche, Hidaya. "What is GABA?". News-Medical. https://www.news-medical.net/health/What-is-GABA.aspx. (accessed October 27, 2020).

  • Harvard

    Aliouche, Hidaya. 2020. What is GABA?. News-Medical, viewed 27 October 2020, https://www.news-medical.net/health/What-is-GABA.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.