Life Science Articles

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Protein Crystallization Screening

High throughput crystallization techniques are frequently employed to generate the large numbers of high purity protein crystals needed for protein crystallography.

2 May 2019

T-Cell Metabolism, Immunodeficiency and Human Disease

T cells are a critical component of the human adaptive immune system and are indispensable in protecting host organism from pathogens.

13 May 2019

Raman Imaging Techniques

Raman imaging techniques are used to obtain information about the molecular vibrations and crystal structure of a sample.

9 May 2019

Mitochondrial DNA Organization and Replication Steps

This article describes the organization of mitochondrial DNA into nucleoids and the replication process, including initiation, elongation, termination and the involvement of polymerase enzymes.

9 May 2019

Raman Spectroscopy: Factors that Affect Spectral Resolution

There are several factors that can affect the spectral resolution of a Raman confocal microscope. This article describes each of these factors and how they can be overcome.

8 May 2019

CRISPR-Cas14: Discovery, Function, Advantages

CRISPR-Cas14 is a variation of the CRISPR-Cas gene editing system which benefits from being simpler and smaller than the other versions.

8 May 2019

Carbon Nanotubes (CNTs) for Targeted Antimicrobial Drug Delivery

Carbon nanotubes show a very good level of cell penetration compared to other drug delivery systems and are less toxic.

8 May 2019

Single-particle Cryo-EM Principles & Uses

Single-particle cryo-EM is an analytical technique used to deduce the 3D structure of macromolecules (particularly proteins) as an alternative to X-Ray crystallography.

2 May 2019

LC-MS for HCP Detection and Analysis

Liquid-chromatography mass spectrometry (LC-MS) is a potential method for detecting HCPs in biopharmaceutical products.

2 May 2019

Human Cell Line Authentication by STR Profiling

Short Tandem Repeat (STR) DNA profiling is one solution that has been proposed for the detection of cross-contamination and therefore authentication of human cell lines.

2 May 2019

Cell‐Cycle‐Dependent Regulation of Cell Adhesions

This article will describe recent studies which have expanded our knowledge of the role of focal adhesions in the cell cycle.

2 May 2019

Cytoophidia Assembly, Morphology & Function

Cytoophidia are filamentous structures present inside a cell that may have important roles in cell compartmentalization.

1 May 2019

Microseeding Explained

Microseeding is a method used in protein crystallography where small seed crystals can be used to induce the formation of larger crystals.

1 May 2019

What are Enhancer RNAs (eRNAs)?

Enhancer RNAs, or eRNAs, are short non-coding RNA molecules that are transcribed from the loci of enhancers.

24 Apr 2019

DNA Repair and Transcription: A Balancing Act

The potential for catastrophic consequence underpins the importance of selecting the correct decision between DNA repair and transcription.

24 Apr 2019

The Role of the CD38 Receptor in the Progression of HIV

The depletion of CD4+ T cells in HIV infection has long been correlated with the overexpression of the cell surface adhesion receptor protein, CD38.

24 Apr 2019

Targeted Proteomics: Benefits and Techniques

An emerging area in the field of proteomics is targeted proteomics, a technique concerned with the quantification of specific proteins.

24 Apr 2019

Eukaryotic DNA Polymerase Enzymes

For all species, the process of DNA replication requires the use of multiple different DNA polymerase enzymes.

1 May 2019

History of DNA Research: Scientific Pioneers & Their Discoveries

This article aims to provide a brief overview of the history of DNA research, leading up to Watson and Crick's discovery of the structure of DNA, and what came next.

1 May 2019