Life Science Articles

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Applying Ultrasound to Cell Sorting

Researchers combined of a microfluidics-based single-cell stream with ultrasound acoustics to yield measurable ultrasound echoes of single cells.

18 Jul 2019

Metabolomic Profiling of an Ancient Herbal Medicine using UHPLC

Researchers have used UHPLC to elucidate the medicinal effects of Baccharis grisebachii, an ancient herbal medicine used in Argentina.

18 Jul 2019

What is the Role of Vascular Endothelial Growth Factor?

Formation of new blood vessels can be divided into two processes – vasculogenesis and angiogenesis.

13 Aug 2019

Separating Flavinoids from Plasma Proteins using UHPLC-MS

Scientists have described a method to separate and characterize flavonoids by digesting plasma proteins with protease enzymes and performing UHPLC-MS.

18 Jul 2019

Improving the Safety of Biotherapeutics: Tracing the Protease Inhibitor AEBSF with RPLC-UV

This article describes how RPLC-UV can be used to remove the common protease inhibitor, AEBSF, from antibody preparations for therapeutic applications.

18 Jul 2019

Detecting Cytokines using Intracellular Flow Cytometry

This article describes the validation of monesin in a 1993 study for use in intracellular flow cytometry for the detection of cytokines.

31 Jul 2019

Biosimilar Drugs: Overview and Industry Challenges

Biosimilar drugs are almost identical versions of a medical product or a drug that are produced by a different company to the parent company.

31 Jul 2019

Detecting Extracellular Vesicles in Urine Using a Robust Assay

This article describes how extracellular vesicles are detected and the development of a robust and reproducible assay that overcomes previous limitations.

31 Jul 2019

Does the Microbiome Interact with the Human Endocrine System?

Whilst the effect of the microbiome on the digestive system has been studied over the past decade, the understanding of its effect on the endocrine system is less well understood.

13 Aug 2019

A Computational Tool for Column Selection in 2D Chromatography

Matching chromatography columns in 2D liquid chromatography largely depends on the experience of the experimenter. The computational technique eliminates this.

25 Jul 2019

Capturing Circulating Leukemia Cells for Analysis by Flow Cytometry

Researchers have developed a new methodology for the characterization of circulating leukemia cells, and other low-abundance cells, by flow cytometry.

25 Jul 2019

Induced Pluripotent Stem (iPS) Cells in Medicine and Research

Induced pluripotent stem cells have led to unprecedented opportunities in the pharmaceutical industry, but also in clinical and basic research

17 Jul 2019

How Important is Intronic Variation?

Intronic variation is highly common, but the majority of variants have no effect. This article describes cases where variants lead to disease.

15 Jul 2019

Pathway Analysis After Genome-Wide Association Studies

Pathway analysis is used to elucidate the impact of each genetic variant thought to be involved in a disease.

15 Jul 2019

Uses of CRISPR/Cas Biosensing Systems

Recently, the Cas9 enzyme has demonstrated potential as a biosensor, and various Cas effectors are now being applied to molecular diagnostics.

4 Jul 2019

Structure and Function of Proteoglycans

Proteoglycans are ubiquitous molecules that function as critical components of the extracellular matrix.

9 Jul 2019

Oligodendrocyte Progenitor Cells: Production and Uses

Oligodendrocytes are involved in the myelination of the axons, which in turn improves the function of the nerves and offers trophic support to longer axons.

9 Jul 2019

Induced Pluripotent Stem (iPS) Cells: Discovery, Advantages and CRISPR Cas9 Gene Editing

Induced pluripotent stem cells (iPS) are somatic cells that can be reprogrammed by expressing a combination of embryonic transcription factors.

17 Jul 2019

Acute Inflammation and the Leukocyte Adhesion Cascade

The movement of leukocytes from the circulatory system to the site of inflammation and subsequent attachment is an integral part of the innate immune system.

4 Jul 2019