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Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

Our bone marrow - the fatty, jelly-like substance inside our bones - is an unseen powerhouse quietly producing 500 billion new blood cells every day.

21 Jun 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

Transforming drug discovery with AI

A new AI-powered program will allow researchers to level up their drug discovery efforts.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Decoding broccoli’s genome: Advances in glucosinolate biosynthesis and health benefits

A detailed genomic study of broccoli has revealed the genetic foundations for the production of glucosinolates (GSLs), compounds celebrated for their health benefits, including anti-carcinogenic properties.

21 Jun 2024

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Researchers identify genetic loci associated with lifetime and frequency of cannabis use.

21 Jun 2024

Using deep learning to design synthetic soluble versions of cell membrane proteins

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

21 Jun 2024

Artificial variants of Withanolides act highly specifically against leukemia cells

Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells.

21 Jun 2024

Advances in organoids and embryonic models pose no risk to personhood, expert argues

Advances in organoids and embryonic models of human development have the potential to prompt social and existential questions - e.g., what defines human individuality? However, bioethicist Insoo Hyun of Harvard Medical School and the Museum of Science in Boston says that these models have the potential to strengthen rather than weaken the concept of human individuality when considered within the philosophical frameworks of "personhood" and sentience.

20 Jun 2024

Breakthrough in enzyme communication could pave the way for new drugs

A mechanism that could help scientists harness enzymes for use in drug discovery has been discovered in a research breakthrough at the University of Birmingham.

20 Jun 2024

Role of SMIM1 gene in obesity uncovered

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

20 Jun 2024

Novel method for 'rationally engineering' enzymes to deliver improved performance

Scientists have prototyped a new method for "rationally engineering" enzymes to deliver improved performance.

20 Jun 2024

Yeast-fermented bread shows promise in preventing asthma symptoms

The effects of a functional bread fermented with yeast (Saccharomyces cerevisiae) in asthma prevention.

20 Jun 2024

Stilla Technologies expands U.S. presence through strategic distribution relationship with Avantor and introduces advanced content offerings

Stilla, a pioneer in the field of genomics and digital PCR, is excited to announce its expansion in the United States via a strategic distribution relationship with Avantor, a global leader in life sciences and advanced technology solutions.

From Stilla Technologies 20 Jun 2024

New cellular atlas revolutionizes understanding of spinal cord injury

Scientists at EPFL have achieved a significant research milestone in the field of spinal cord injuries - mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'.

19 Jun 2024

Study shows the critical role of time cells in complex behavioral learning

A sense of time is fundamental to how we understand, recall, and interact with the world.

19 Jun 2024

Novel AI tool poised to reshape virtual screening in early stage drug discovery

Australian researchers, led by Monash University, have invented a new artificial intelligence (AI) tool which is poised to reshape virtual screening in early stage drug discovery and enhance scientists’ ability to identify potential new medicines.

19 Jun 2024

Researchers propose a 'protein aggregation clock' to measure aging and health

Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Professor Dorothee Dormann and Professor Edward Lemke of Johannes Gutenberg University Mainz (JGU), who are also adjunct directors at the Institute of Molecular Biology (IMB) in Mainz, propose the concept of a "protein aggregation clock" to measure ageing and health in a new perspective article published in Nature Cell Biology.

19 Jun 2024

New bone marrow atlas offers detailed view of cell function and organization

While research has uncovered many details about how blood cells function within bone marrow, the work of other cells existing in that space remained a relative mystery.

18 Jun 2024

Life Science News

Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

How random gene activity shapes lifespan in C. elegans

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Transforming drug discovery with AI

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Decoding broccoli’s genome: Advances in glucosinolate biosynthesis and health benefits

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Using deep learning to design synthetic soluble versions of cell membrane proteins

Artificial variants of Withanolides act highly specifically against leukemia cells

Advances in organoids and embryonic models pose no risk to personhood, expert argues

Breakthrough in enzyme communication could pave the way for new drugs

Role of SMIM1 gene in obesity uncovered

Novel method for 'rationally engineering' enzymes to deliver improved performance

Yeast-fermented bread shows promise in preventing asthma symptoms

Stilla Technologies expands U.S. presence through strategic distribution relationship with Avantor and introduces advanced content offerings

New cellular atlas revolutionizes understanding of spinal cord injury

Study shows the critical role of time cells in complex behavioral learning

Novel AI tool poised to reshape virtual screening in early stage drug discovery

Researchers propose a 'protein aggregation clock' to measure aging and health

New bone marrow atlas offers detailed view of cell function and organization

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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