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Breast cancer drug development work moves forward with support from STTR grant

Triple negative breast cancer is an aggressive subtype of breast cancer with worse survival outcomes than most.

14 Jun 2023

Synthetic compound used in perfumes shows potential to stop coagulopathy during a massive hemorrhage

The chances of surviving massive blood loss from a traumatic injury such as a gunshot wound are around 50 percent. To survive, a patient needs two things to happen quickly: a large infusion of blood and coagulation at the wound to stop the bleeding.

14 Jun 2023

CrossDome tool helps predict the potential risks of T-cell immunotherapy

Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells.

14 Jun 2023

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Crossing the membrane is a major challenge on the journey through the cell. Large biomolecules usually benefit from different transport strategies to overcome the lipid bilayer, so the design and synthesis of new carriers is key for the delivery of hydrophilic substances, such as pharmaceuticals, into the cell.

14 Jun 2023

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Neuroscientists have long searched for ways to reopen "critical periods" in the brain, when mammals are more sensitive to signals from their surroundings that can influence periods of brain development.

14 Jun 2023

Researchers create a diagnostic test to identify functional sperm in infertile men

In a recent study, researchers created a diagnostic test to identify functional sperm in infertile men that could change the treatment of male infertility and assisted reproductive technology.

14 Jun 2023

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

University of Queensland researchers have used an algorithm from a video game to gain insights into the behavior of molecules within live brain cells.

14 Jun 2023

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

Surf's up, sharks down: Study finds low shark bite risk despite overlapping human-shark activity in Southern California

In a study published in the journal PLOS ONE, scientists have determined the spatio-temporal habit overlap between juvenile white sharks and humans across the entire southern California coastline.

13 Jun 2023

Scientists show how pregnancy induces progressive changes in the maternal immune system

We have a good understanding of how a woman's external features can change during pregnancy, but scientists know surprisingly little about what biological changes occur internally.

13 Jun 2023

Molecule found in the venomous toadfish controls lung inflammation in mice

A molecule found in the venomous toadfish Thalassophryne nattereri has proved capable of controlling lung inflammation and could be the basis for a more effective asthma drug.

13 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals - from fuels to fabrics and drugs - beyond the normal repertoire of microbes.

13 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

13 Jun 2023

Heat-damaged DNA in food may contribute to genetic risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

13 Jun 2023

New process for creating a “meta-cell overcomes the challenges of studying single-cell secrets

University of California, Irvine neuroscientists probing the gene changes behind Alzheimer's disease have developed a process of making a "meta-cell" that overcomes the challenges of studying a single cell.

13 Jun 2023

Study shows link between death perception and reduced aging in flies

Researchers led by Christi Gendron at the University of Michigan, US, have found the link between death perception and reduced aging in flies.

13 Jun 2023

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

Tracing the ancestry of hybrids using a new method

If you've ever kept a garden, you're probably familiar with hybrids, from disease-resistant tomatoes to Stargazer lilies.

13 Jun 2023

UCL researchers produce first image of the structures that power human cilia

The first image of the structures that power human cilia – the tiny, hairlike projections that line our airways – has been produced by a team involving UCL researchers and could lead to much-needed treatments for people with rare cilial diseases.

13 Jun 2023

Life Science News

Breast cancer drug development work moves forward with support from STTR grant

Synthetic compound used in perfumes shows potential to stop coagulopathy during a massive hemorrhage

CrossDome tool helps predict the potential risks of T-cell immunotherapy

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Researchers create a diagnostic test to identify functional sperm in infertile men

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Surf's up, sharks down: Study finds low shark bite risk despite overlapping human-shark activity in Southern California

Scientists show how pregnancy induces progressive changes in the maternal immune system

Molecule found in the venomous toadfish controls lung inflammation in mice

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Heat-damaged DNA in food may contribute to genetic risks

New process for creating a “meta-cell overcomes the challenges of studying single-cell secrets

Study shows link between death perception and reduced aging in flies

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Tracing the ancestry of hybrids using a new method

UCL researchers produce first image of the structures that power human cilia

Edoardo Fabini

Reducing polypharmacy through innovative drug formulation technologies

How innovation in dried blood spot testing is transforming neurological disease monitoring

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