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Regeneron forms consortium to accelerate largest widely-available human sequencing resource

By the end of 2019, Regeneron plans to sequence the exomes of all 500,000 people within the UK Biobank resource, all with associated health records, creating an unprecedented resource linking human genetic variations to human biology and disease.

9 Jan 2018

Identical twins share additional level of molecular similarity

An international group of researchers has discovered a new phenomenon that occurs in identical twins: independent of their identical genes, they share an additional level of molecular similarity that influences their biological characteristics.

9 Jan 2018

Variations in singular genes could have large impact on hereditary facial features

Do you have your grandmother's eyes? Or your father's nose? A new study by the Universities of Oxford and Surrey has uncovered variations in singular genes that have a large impact on human facial features, paving the way to understanding what determines the facial characteristics passed on from generation to generation.

9 Jan 2018

Researchers develop drug that supports cellular traffic jam theory in ALS/FTD

Neurodegeneration in ALS/FTD may be caused by TDP-43 aggregation in the cytoplasm, causing cellular traffic jams. The trial drug can sequester TDP-43.

9 Jan 2018

Deciphering Antibodies with Next-Generation Protein Sequencing Technology

Mr. Mingjie Xie, MSc, MBA, is the co-founder and CEO of Rapid Novor Inc. He is a computer scientist by training andreceived his MSc degree from Western University in the field of bioinformatics. He received his MBA degree from Richard Ivey School of Business to pursue his interests in business. Prior to co-founding Rapid Novor Inc, Mingjie is the COO of a bioinformatics software company.

From Rapid Novor Inc 9 Jan 2018

Survival strategy of mRNAs during sugar deficiency in the cell

If a cell runs low on sugar, it stores certain messenger RNAs in order to prolong its life. As a research group at the Biozentrum of the University of Basel has now discovered, the protein Puf5p determines whether individual messenger RNAs will be stored or degraded when sugar levels are low.

9 Jan 2018

WPI professor receives Smith Family Foundation grant to explore biology of cancer cells

Amity Manning, assistant professor of biology and biotechnology, has received a three-year, $300,000 award from the Smith Family Awards Program for Excellence in Biomedical Research.

8 Jan 2018

Researchers discover mutations in a gene related to obesity

Researchers have discovered mutations in a gene related to obesity, offering new treatment possibilities in the fight against the global epidemic.

8 Jan 2018

Study finds a cellular mechanism that protects plant genes from impacts of mutation

According to a new study conducted at the University of Oxford, a cellular mechanism termed DNA mismatch repair (MMR), preferentially protects plant genes from the damaging impacts of mutation.

8 Jan 2018

Polygenic risk score predicts early-onset heart disease risk

A risk score based on multiple genetic differences, or polygenic risk score, predicted significantly more cases of early-onset heart disease than standard tests for single genetic defects, according to new research in the American Heart Association's journal Circulation: Genomic and Precision Medicine.

8 Jan 2018

Bielefeld scientists discover cause of initially unclear symptoms

The sequencing of the human genome has made it possible: nowadays scientists can discover potential disorders for which there are no known patients.

5 Jan 2018

University of Montana researchers make discovery on unusual gene evolution in bacteria

University of Montana researchers have made another discovery at the cellular level to help understand the basic processes of all life on our planet - this time within the unusual bacteria that has lived inside cicada insects since dinosaurs roamed Earth.

5 Jan 2018

Newly described super-silenced DNA reveals novel approach to reprogram cells

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study in Molecular Cell last week by investigators from the Perelman School of Medicine at the University of Pennsylvania.

5 Jan 2018

Genetic differences can influence efficiency of medicines

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency.

5 Jan 2018

Cellular mechanism protects genes from damaging effects of mutation

Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.

5 Jan 2018

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis.

5 Jan 2018

Researchers use genomic technologies to better understand risk factor for stomach cancer

A research team led by National University Health System and Duke-NUS Medical School has used genomic technologies to better understand intestinal metaplasia, a known risk factor for gastric (stomach) cancer.

5 Jan 2018

Study suggests vitamin C enhances tuberculosis drugs effectiveness

A new study conducted by researchers at the Albert Einstein College of Medicine, Bronx, NY, proposed the use of vitamin C together with tuberculosis drugs for rapid eradication of the disease-causing pathogens. The studies were carried out on mice and in tissue cultures and the results have been published in the journal of American Society for Microbiology, Antimicrobial Agents and Chemotherapy.

5 Jan 2018

Study finds link between dietary sugar and increasing bacterial epidemics

The rising frequency and severity of Clostridium difficile infections may be caused by the commonly used food additive, trehalose, according to Nature.

5 Jan 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018