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Penn researchers discover how DNA damage turns immune cells against cancer

Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes.

31 Jul 2017

DNA-sensing mechanism of innate immune system controls cellular senescence

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old".

31 Jul 2017

Mettler Toledo announce online seminar on continuous flow chemistry

METTLER TOLEDO has announced a new online seminar, titled Flow Chemistry Development and Scale-up. Each presentation includes examples of how simple PAT tools have become integrated into continuous flow chemistry to expedite process development. Each presenter will share a series of technical case studies.

From Mettler-Toledo International Inc. 31 Jul 2017

Physiology-driven genetic changes have positive influence on brain development

SCIENTISTS in the UK and India have discovered more evidence that positive stimuli in early childhood can benefit the infant brain.

31 Jul 2017

Bringing highly potent cell therapy products to market

There are two main challenges and both relate to manufacturing. The first one is to make sure you can manufacture therapies with reasonable costs and the second one is to make sure that you can balance the capacity you need with the demands.

31 Jul 2017

Methamphetamine use does not only cause death through overdose, warn researchers

Overdose is not the only cause of death among people who die as a result of using the drug methamphetamine or “ice,” say researchers.

31 Jul 2017

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA.

29 Jul 2017

Ultra-sensitive C. difficile toxin assay may be critical tool for improving diagnosis of infectious disease

Findings presented at the American Society for Microbiology's ASM Microbe conference show that the ultra-sensitive Clostridium difficile toxin A/B assay in development for use on the Sgx Clarity™ system offers excellent sensitivity and may be a critical tool for improving the diagnosis of this life-threatening infection.

29 Jul 2017

STRATEC Molecular offers new products to improve liquid biopsy

Liquid biopsy is a new technology for detection and analysis of biomarkers in blood or other body fluids without the need of invasive procedures.

28 Jul 2017

Diminished taste sensitivity could put people on path to gaining weight

Cornell University food scientists have found that people with a diminished ability to taste food choose sweeter- and likely higher-calorie - fare. This could put people on the path to gaining weight.

28 Jul 2017

Science of judging speed: Perceptions of 'normal' get unconsciously altered by recent experiences

Football officials watching slow-motion clips or drivers changing from motorways to 30mph zones could be unconsciously mis-judging speed - and the motivations behind a person's movements - because their perceptions of 'normal' have been altered by recent experiences, new research has found.

28 Jul 2017

Structure of protein in salmon virus could inform strategies to treat flu in humans

The structure of a protein key to the survival and spread of a virus that affects salmon could inform strategies to treat the flu in humans, according to scientists at Rice University.

28 Jul 2017

Researchers compare bone-healing effects of three low-dose growth factors

Researchers compared the effects of three bone growth factors to bone morphogenetic protein 2 (BMP2) -- the most commonly used agent for repair of large bone defects, which is not without risks at the doses required--and showed significant bone-healing effects including the formation of new blood vessels at low doses relative to BMP2.

28 Jul 2017

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine have begun to unravel the mystery of how acidity influences a small protein called serum amyloid A (SAA).

28 Jul 2017

Molecule plays essential role in establishing proper neural wiring in the cerebellum

Researchers at Hokkaido University have found that the molecule "L-gutamate/L-aspartate transporter" (GLAST) plays an essential role in establishing and maintaining proper neural wiring of Purkinje cells in the cerebellum.

28 Jul 2017

Estrogen uses certain cell type as 'mediator' for beneficial effects on the bone, research shows

The female sex hormone estrogen plays an important role in the structural stability of bones. To date, however, it had been unclear exactly which cells were involved in the hormone's protective function in preventing changes in bone density.

28 Jul 2017

Spider threads show great potential for nerve and tissue repair

The golden orb-weaver spider from Tanzania spins such strong webs that Tanzanian fishermen use them for fishing.

28 Jul 2017

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease remained a mystery. Now, researchers at UT Southwestern Medical Center have uncovered an intriguing clue.

28 Jul 2017

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Insilico Medicine, a Baltimore-based leader in artificial intelligence for drug discovery and biomarker development, is pleased to announce a multi-year drug development agreement with the biotechnology company Juvenescence AI Limited.

28 Jul 2017

Roche receives FDA clearance for new high-volume testing immunoassay solution

Roche announced today that its new, dedicated high-volume testing immunoassay solution for the cobas 8000 modular analyzer series, the cobas e 801 module, has received 510(k) clearance from the U.S. Food and Drug Administration.

27 Jul 2017

Life Science News

Penn researchers discover how DNA damage turns immune cells against cancer

DNA-sensing mechanism of innate immune system controls cellular senescence

Mettler Toledo announce online seminar on continuous flow chemistry

Physiology-driven genetic changes have positive influence on brain development

Bringing highly potent cell therapy products to market

Methamphetamine use does not only cause death through overdose, warn researchers

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Ultra-sensitive C. difficile toxin assay may be critical tool for improving diagnosis of infectious disease

STRATEC Molecular offers new products to improve liquid biopsy

Diminished taste sensitivity could put people on path to gaining weight

Science of judging speed: Perceptions of 'normal' get unconsciously altered by recent experiences

Structure of protein in salmon virus could inform strategies to treat flu in humans

Researchers compare bone-healing effects of three low-dose growth factors

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Molecule plays essential role in establishing proper neural wiring in the cerebellum

Estrogen uses certain cell type as 'mediator' for beneficial effects on the bone, research shows

Spider threads show great potential for nerve and tissue repair

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Roche receives FDA clearance for new high-volume testing immunoassay solution

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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