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Vaccinia-based COVID-19 vaccines confer immunity in hamster model

In a paper recently uploaded to the preprint server bioRxiv* by Kulkarni et al. (August 3, 2021), the potential of vaccinia virus-based vaccines expressing the full-length SARS-CoV-2 spike protein is examined in mice and Syrian hamsters. The findings report that the vaccine generates high titers of neutralizing antibodies with good activity towards SARS-CoV-2 variants of concern.

5 Aug 2021

New study examines B cell receptor repertoires in COVID-19 patients

In a paper recently uploaded to the preprint server bioRxiv* by Kim et al. (August 2, 2021), the B cell receptor repertoire of 1,060 COVID-19 patients is compared to that of an equal number of healthy volunteers in a novel manner, utilizing computational deep-learning-based protein embedding techniques, which demonstrate a resolution capable of tracking the changes in immunity in an individual over the course of infection.

5 Aug 2021

Neural network model unravels why people with autism have difficulty interpreting facial expressions

People with autism spectrum disorder have difficulty interpreting facial expressions.

5 Aug 2021

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

In a recently published article in The New England Journal of Medicine, scientists have described how multi-mutational variants of SARS-CoV-2 may evolve in patients with immunosuppression.

5 Aug 2021

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

Modified mRNA combined with lipid nanoparticles may be beneficial in boosting adaptive immunity against SARS-CoV-2. Research led by Botond Z. Igyártó from Thomas Jefferson University’s Department of Microbiology and Immunology in Pennsylvania recently found that the lipid nanoparticles induce protective adaptive immune responses with antibody titers against lethal doses of the virus.

5 Aug 2021

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

A new study from the National Centre for Biotechnology and Medicinal Chemistry Institute suggests Mother Nature delivered — in the form of liverworts. They found that the bryophyte Marchantia polymorpha, also known as umbrella liverworts, could work as a potential antiviral treatment.

5 Aug 2021

Mobile apps can help promote physical activity during COVID-19 lockdown

Gyms and sporting clubs might close, and lockdown conditions make it difficult to exercise, but people are urged to take the next step and download fitness apps to keep moving.

5 Aug 2021

RIZE’s XRIZE Full-Color Printer Now Compatible with Synopsys Simpleware for 3D Medical Printing

RIZE, Inc. today announced that its XRIZE® 3D printing platform is compatible with Synopsys’ FDA 510(k)-cleared Simpleware™ software.

From Synopsys Simpleware™ Software 5 Aug 2021

Vitamin D supplementation could reduce opioid doses in palliative cancer treatment

Patients with vitamin D deficiency who received vitamin D supplements had a reduced need for pain relief and lower levels of fatigue in palliative cancer treatment, a randomized and placebo-controlled study by researchers at Karolinska Institutet in Sweden shows.

5 Aug 2021

Post-COVID-19 neurological sequalae are not due to brain injury, study shows

In a recent study from University of Gothenburg, it has been shown that all participants achieve normalization of CNS injury biomarkers, regardless of previous disease severity or persistent neurological symptoms. Indicating that post-COVID-19 neurological sequalae are not due to active brain injury.

5 Aug 2021

2+2=? Senate uses murky math as it shelves drug pricing rule to fund infrastructure

The Senate’s release of its bipartisan infrastructure plan signals that lawmakers are poised to throw former President Donald Trump’s belated bid to lower Medicare drug prices under the bus — not to mention trains, bridges, tunnels and broadband connections.

5 Aug 2021

Feds to nix work requirements in Montana Medicaid expansion program

Federal health officials will likely reject Montana's request to include work requirements for beneficiaries of its Medicaid expansion program, which insures 100,000 low-income Montana adults, state officials said.

5 Aug 2021

Men have better resources than women to cope with challenges of aging

Gender differences in societal ageing favor men over women, which suggests that men have better resources to help them cope with the challenges of ageing.

5 Aug 2021

Pandemic job search anxiety could lead to both positive and negative results

Job seeking, even during a good year, can be a stressful experience. Add in a global pandemic and constrained job markets, and anxiety abounds in many job seekers. That anxiety can be tied to both positive and negative results, according to new research out of the University of Arizona Eller College of Management.

5 Aug 2021

Contingency management at end-of-treatment helps to overcome opioid use disorder

The opioid epidemic remains a U.S. public health crisis and has only worsened since the COVID-19 pandemic began in 2020, with opioid deaths accounting for 69,000 of 93,000 overdose-related deaths in 2020, according to provisional drug overdose data released by the U.S. Centers for Disease Control and Prevention in July 2021.

5 Aug 2021

Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern

Researchers in the United States and Canada have described the structural basis and mode of action for two monoclonal antibodies that potently neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

4 Aug 2021

Monoclonal antibody could inform development of pan-coronavirus vaccines

Researchers in the United States have demonstrated the potential of a monoclonal antibody to inform the design of pan-coronavirus vaccines that could prevent the outbreak of future pandemics such as coronavirus disease 2019 (COVID-19).

4 Aug 2021

The role of natural killer cells in the fight against coronavirus infection

This study proposes a mathematical framework to analyze the effect of the viruses on type I interferon (IFN-I) signaling, which is part of the innate immune response. IFN-I brings about natural killer cell activation, which in turn causes the activation of macrophages.

4 Aug 2021

Medical associations join forces to remove regulatory barriers to noninvasive ventilation

On July 30, 2021, the journal CHEST® electronically published the outcomes and recommendations of a technical expert panel on optimal noninvasive ventilation, conducted by the American College of Chest Physicians, the American Academy of Sleep Medicine, the American Association for Respiratory Care, and the American Thoracic Society.

4 Aug 2021

First United Nations resolution on preventable sight loss paves the way for real action on eye health

The International Centre for Eye Health based at the London School of Hygiene & Tropical Medicine joins the eye health community in celebrating the passing of the first United Nations resolution on preventable sight loss.

4 Aug 2021

Medical News

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

New study examines B cell receptor repertoires in COVID-19 patients

Neural network model unravels why people with autism have difficulty interpreting facial expressions

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

Mobile apps can help promote physical activity during COVID-19 lockdown

RIZE’s XRIZE Full-Color Printer Now Compatible with Synopsys Simpleware for 3D Medical Printing

Vitamin D supplementation could reduce opioid doses in palliative cancer treatment

Post-COVID-19 neurological sequalae are not due to brain injury, study shows

2+2=? Senate uses murky math as it shelves drug pricing rule to fund infrastructure

Feds to nix work requirements in Montana Medicaid expansion program

Men have better resources than women to cope with challenges of aging

Pandemic job search anxiety could lead to both positive and negative results

Contingency management at end-of-treatment helps to overcome opioid use disorder

Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern

Monoclonal antibody could inform development of pan-coronavirus vaccines

The role of natural killer cells in the fight against coronavirus infection

Medical associations join forces to remove regulatory barriers to noninvasive ventilation

First United Nations resolution on preventable sight loss paves the way for real action on eye health

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

The importance of ketones from a clinical and medical perspective

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