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Mutational targets of SARS-CoV-2 receptor-binding domain for vaccine-antiviral development

The COVID-19 pandemic has spread throughout the whole world within six months, causing millions of infections and hundreds of thousands of deaths. Yet there is no effective vaccine or antiviral to deal with it.

18 Jun 2020

Study: Oregon's gender-affirming health care policies are not fully realized in practice

While Oregon ranks highly nationwide for its gender-affirming policies and health care for transgender women, many of those polices are not fully realized in practice, a recent study from Oregon State University found.

18 Jun 2020

Crystal structure of SARS-CoV-2 protease-inhibitor in complex with a Chinese herb Shikonin

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been spreading rampantly over the whole world, infecting millions of people (over 8.45 million at last count), with over 452,000 deaths, as of June 19, 2020. It causes a broad spectrum of disease manifestations, from asymptomatic disease to severe or even fatal respiratory symptoms.

18 Jun 2020

Researchers caution use of chloroquine therapy for patients at higher risk of heart rhythm abnormalities

A patient who met many of the published safety guidelines for chloroquine therapy against COVID-19 was observed to have a very abnormal ECG pattern after treatment began, leading to multiple episodes of torsade de pointes (TdP), a life-threatening arrhythmia in which the lower chambers of the heart beat out of sync with the upper chambers.

18 Jun 2020

Not having surgery lowers risk of stroke, death in patients with brain AVMs

For patients with brain arteriovenous malformations, not having surgery or getting radiation therapy can result in an almost 70-per-cent lower risk of having a stroke or dying, researchers find.

18 Jun 2020

Study reveals how COVID-19 pandemic has impacted cancer patients' quality of life

Patients with cancer face a serious dilemma during the COVID-19 pandemic, as staying at home could increase their risk of cancer progression, while visiting the hospital for treatment could increase their risk of becoming infected with the virus that causes COVID-19.

18 Jun 2020

Neighborhood socioeconomic status and household crowding associated with COVID-19

A study of nearly 400 pregnant women in New York City is among the first to show that lower neighborhood socioeconomic status and greater household crowding increase the risk of becoming infected with SARS-CoV-2, the virus that causes COVID-19.

18 Jun 2020

AFFiRiS AG announces results of phase 1 trial with PD01A in Parkinson's

AFFiRiS AG, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies (SAITs), today announced that detailed results of the phase 1 clinical program with its lead candidate PD01 in early Parkinson's disease (PD) patients were published in the peer-reviewed journal The Lancet Neurology.

18 Jun 2020

Novel SARS-CoV-2 antibody cocktail impeccably mimics human antibody response

By using both humanized mice and convalescent patients, the researchers from the US and Singapore successfully generated non-competing and highly potent monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein that could potentially be combined to form antibody cocktails. Their groundbreaking paper is published in the leading research journal Science.

18 Jun 2020

Global experts develop open-source N95 face mask

In one of the latest COVID-19 response projects at the University of Massachusetts Amherst, the Advanced Digital Design and Fabrication laboratory is collaborating with a global network of design, engineering and manufacturing experts to help develop an open-source N95 face mask.

18 Jun 2020

Discovery of key steps in kidney formation could have implications for treating renal diseases

The discovery of how certain key structures in the kidneys are formed could have important implications for treating renal fibrosis (or scarring), a feature of chronic kidney disease (CKD), according to a new study by a researcher at Massachusetts General Hospital.

18 Jun 2020

Throat gargling may be beneficial during the COVID-19 pandemic

Researchers from Chang Gung University College of Medicine, Taiwan, have suggested that throat gargling may have beneficial effects during the coronavirus disease 2019 (COVID-19) pandemic.

18 Jun 2020

COVID-19 collaborative program reduces mortality in long-term care facilities

A collaborative program developed at UVA Health to work with local long-term care facilities control COVID-19 is saving lives and offers a model for communities across the country, a new scientific paper reports.

18 Jun 2020

Mutations linked to intellectual disability, epileptic seizures affect ion channel's function

Two mutations identified in individuals with developmental and epileptic brain disease can be traced back to the same ion channel.

18 Jun 2020

Parasitic worms could offer new treatment hope for MS patients

Parasitic worms could offer a new treatment hope for patients suffering from the autoimmune disease multiple sclerosis, according to experts from the University of Nottingham.

18 Jun 2020

First genome-wide CRISPR screen reveals genes that control SARS-CoV-2 infection

By performing a genome-wide CRISPR screen on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), U.S. researchers identified novel proviral genes and pathways, and highlighted host genes that may regulate coronavirus disease (COVID-19) pathogenesis, as well as revealing potential targets for novel treatment approaches. Their findings are currently available on the bioRxiv* preprint server.

18 Jun 2020

COVID-19 pandemic affects sexual and reproductive health of young people

Social distancing and limited access to contraceptive and abortion care during the COVID-19 pandemic is affecting the sexual and reproductive health of adolescents and young adults according to a new study by researchers at Columbia University Mailman School of Public Health and Rutgers University.

18 Jun 2020

Overcoming leukemia treatment resistance with nanoparticle drug delivery system

UConn associate professor of pharmaceutics Xiuling Lu, along with professor of chemistry Rajeswari M. Kasi, was part of a team that recently published a paper in Nature Cell Biology finding a commonly used chemotherapy drug may be repurposed as a treatment for resurgent or chemotherapy-resistant leukemia.

18 Jun 2020

COVID-19 pandemic may have negative consequences for mental health

The global COVID-19 pandemic has affected the physical lives of most people. But now there are also indications that the pandemic has negative consequences for the mental health of the people being infected, the healthcare professionals and the population as a whole.

18 Jun 2020

DFG establishes interdisciplinary commission to strengthen pandemic research

Against the background of the current coronavirus pandemic, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is to establish an interdisciplinary commission for pandemic research.

18 Jun 2020

Medical News

Mutational targets of SARS-CoV-2 receptor-binding domain for vaccine-antiviral development

Study: Oregon's gender-affirming health care policies are not fully realized in practice

Crystal structure of SARS-CoV-2 protease-inhibitor in complex with a Chinese herb Shikonin

Researchers caution use of chloroquine therapy for patients at higher risk of heart rhythm abnormalities

Not having surgery lowers risk of stroke, death in patients with brain AVMs

Study reveals how COVID-19 pandemic has impacted cancer patients' quality of life

Neighborhood socioeconomic status and household crowding associated with COVID-19

AFFiRiS AG announces results of phase 1 trial with PD01A in Parkinson's

Novel SARS-CoV-2 antibody cocktail impeccably mimics human antibody response

Global experts develop open-source N95 face mask

Discovery of key steps in kidney formation could have implications for treating renal diseases

Throat gargling may be beneficial during the COVID-19 pandemic

COVID-19 collaborative program reduces mortality in long-term care facilities

Mutations linked to intellectual disability, epileptic seizures affect ion channel's function

Parasitic worms could offer new treatment hope for MS patients

First genome-wide CRISPR screen reveals genes that control SARS-CoV-2 infection

COVID-19 pandemic affects sexual and reproductive health of young people

Overcoming leukemia treatment resistance with nanoparticle drug delivery system

COVID-19 pandemic may have negative consequences for mental health

DFG establishes interdisciplinary commission to strengthen pandemic research

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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