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Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi Minh City (Vietnam).

22 May 2025

Living in disadvantaged neighborhoods linked to earlier menopause

A new study led by the Harvard Pilgrim Health Care Institute highlights the significant impact of living in disadvantaged neighborhoods on the onset of menopause.

22 May 2025

Endurance training leads to significant drops in vascular resistance and diastolic blood pressure

Eight months of supervised marathon training in Finnish adults led to moderate reductions in peripheral diastolic blood pressure, systemic vascular resistance, and extracellular water volume. Central (aortic) blood pressure showed a non-significant decline, highlighting the specific impact of exercise on vascular health.

22 May 2025

Infrared vision achieved through new nanoparticle contact lenses

Neuroscientists and materials scientists have created contact lenses that enable infrared vision in both humans and mice by converting infrared light into visible light.

22 May 2025

Early childhood weight patterns linked to future obesity risk

Not all children grow the same way. A new study from the Environmental influences on Child Health Outcomes (ECHO) Program suggests that body weight changes in early childhood may be associated with later obesity risk.

22 May 2025

Natural compounds from Brazilian plants show promise against stomach cancer

A new review was published in Volume 12 of Oncoscience on May 8, 2025, titled "The chemopreventive effects of native Brazilian plants on stomach cancer: A review of the last 25 years."

22 May 2025

Guideline-directed medical therapy boosts survival in the oldest heart attack patients

Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, can improve survival rates in patients 90 years of age and older following their first heart attack, with the greatest benefit observed in patients who received all four recommended post-acute myocardial infarction (AMI) therapies.

22 May 2025

Understanding how cholera bacteria resist phage predation

When we think of cholera, most of us picture contaminated water and tragic outbreaks in vulnerable regions. But behind the scenes, cholera bacteria are locked in a fierce, microscopic war-one that could shape the course of pandemics.

22 May 2025

Mediterranean eating habits help European children fight genetic obesity risk

A large European cohort study found that adherence to the Mediterranean diet mitigates the impact of genetic risk for obesity in children, especially in early childhood. High consumption of vegetables and legumes was linked to lower obesity risk, regardless of genetic predisposition.

22 May 2025

Unlocking the secrets of human longevity and healthy aging

Human healthy aging and longevity are complex phenomena influenced by a dynamic interplay of genetic, epigenetic, metabolic, immune, and environmental factors.

22 May 2025

Catalpol shows neuroprotective effects across multiple neurologic conditions

Announcing a new publication for Acta Materia Medica journal. Neurologic disorders are the leading cause of illness and disability as a result of increased life expectancy and global population aging, highlighting the urgent need and great challenge for discovering neuroprotective agents with better efficacy and minimal side-effects.

22 May 2025

Researchers establish a new golden standard for human lactation studies

Women who choose to stop treatment during pregnancy and breastfeeding are putting their health at risk, and have to weigh their desire to have children and breastfeed against a risk that we know very little about.

22 May 2025

Leaving out numbers in medical communication may mislead patients

When a physician says a procedure is "rarely risky," what does that really mean? Although terms like "common" and "unlikely" may sound descriptive enough, experts in medical decision-making suggest that leaving out numbers may be misleading for patients.

22 May 2025

New smartphone app can help detect heart attacks and strokes

A potentially lifesaving new smartphone app can help people determine if they are suffering heart attacks or strokes and should seek medical attention, a clinical study suggests.

22 May 2025

Volunteers help tornado-hit St. Louis amid wait for federal aid

Kevin Hines has been living in a house without a roof in the days since a tornado devastated his community. He has seen some of his neighbors sleeping in their cars. A different man has spent untold hours on a bench.

22 May 2025

Meta analysis highlights prognostic role of circPVT1 in solid tumors

circPVT1 has emerged as a key regulator in disease progression and clinical outcomes. However, its prognostic relevance and association with clinicopathological parameters in solid malignancies remain to be fully elucidated.

22 May 2025

New AI blood test tracks pancreatic cancer treatment response

An artificial intelligence technique for detecting DNA fragments shed by tumors and circulating in a patient's blood, developed by Johns Hopkins Kimmel Cancer Center investigators, could help clinicians more quickly identify and determine if pancreatic cancer therapies are working.

22 May 2025

Gut bacteria and diet found to affect cancer treatment outcomes

A Ludwig Cancer Research study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.

22 May 2025

Study assures safety of triptan use during pregnancy for migraine sufferers

There's good news for people with migraine who take common drugs before or during pregnancy-a new study found no increase in neurodevelopmental disorders such as autism and ADHD in their children.

22 May 2025

Supplemental imaging techniques improve cancer detection in women with dense breasts

In women with dense breasts (breasts with relatively low levels of fatty tissue) and a negative mammogram, supplemental imaging techniques detect early-stage cancers, with imaging techniques three times more effective than ultrasound, finds a phase 3 randomized control trial published in The Lancet.

22 May 2025