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Study suggests Golgi as potential drug target for Alzheimer's treatment

Alzheimer's disease (AD) progresses inside the brain in a rising storm of cellular chaos as deposits of the toxic protein, amyloid-beta (Aβ), overwhelm neurons. An apparent side effect of accumulating Aβ in neurons is the fragmentation of the Golgi apparatus, the part of the cell involved in packaging and sorting protein cargo including the precursor of Aβ. But is the destruction the Golgi a kind of collateral damage from the Aβ storm or is the loss of Golgi function itself part of the driving force behind Alzheimer's? This was the question for Yanzhuang Wang, Gunjan Joshi, and colleagues at the University of Michigan, Ann Arbor, as they set out to uncover the mechanism damaging the Golgi, using a transgenic mouse and tissue culture models of AD to look at what was going on.

6 Dec 2014

Genetics may play major role in Lou Gehrig's disease, study reveals

Genetics may play a larger role in causing Lou Gehrig's disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS.

6 Dec 2014

Research findings may lead to new ways to thwart drug resistance

Penicillin, the wonder drug discovered in 1928, works in ways that are still mysterious almost a century later. One of the oldest and most widely used antibiotics, it attacks enzymes that build the bacterial cell wall, a mesh that surrounds the bacterial membrane and gives the cells their integrity and shape. Once that wall is breached, bacteria die -- allowing us to recover from infection.

6 Dec 2014

Study sheds new light on well-known mechanism required for immune response

A new study published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America sheds new light on a well-known mechanism required for the immune response. Researchers at the IRCM, led by Tarik Möröy, PhD, identified a protein that controls the activity of the p53 tumour suppressor protein known as the "guardian of the genome".

6 Dec 2014

Study links poor semen quality to higher risk of various health conditions

A study of more than 9,000 men with fertility problems has revealed a correlation between the number of different defects in a man's semen and the likelihood that the man has other health problems.

6 Dec 2014

Researchers suggest new strategy to control cellular identity and fate

A team of scientists that included researchers from UCLA has discovered a novel mechanism of RNA regulation in embryonic stem cells. The findings are strong evidence that a specific chemical modification, or "tag," on RNA plays a key role in determining the ability of embryonic stem cells to adopt different cellular identities.

6 Dec 2014

Malnutrition predicts long-term survival in elderly patients undergoing Whipple procedure

Malnutrition is an important factor predicting long-term survival in older patients undergoing pancreaticoduodenectomy (PD) (commonly called the Whipple procedure) to treat benign tumors and cysts of the pancreas as well as pancreatitis, according to new study results published in the December issue of the Journal of the American College of Surgeons.

6 Dec 2014

Researchers identify important neural mechanism responsible for certain chronic pain disorders

Pain typically has a clear cause-but not always. When a person touches something hot or bumps into a sharp object, it's no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, a gentle caress can result in agony.

6 Dec 2014

University of Utah professor develops MORE intervention program for chronic pain patients

How can people who are dependent on prescription opioids reduce their cravings? Learn to enjoy other aspects of their lives.

6 Dec 2014

Exposure to chemicals used in UOG operations may affect reproductive and developmental health

Unconventional oil and gas (UOG) operations combine directional drilling and hydraulic fracturing, or "fracking," to release natural gas from underground rock. Recent discussions have centered on potential air and water pollution from chemicals used in these processes and how it affects the more than 15 million Americans living within one mile of UOG operations.

6 Dec 2014

Maria T. Lymberis to receive 2014 Gary S. Nye Award for Physician Health and Well-Being

Maria T. Lymberis, MD, a member of the Cooperative of American Physicians, Inc., will be honored with the 2014 Gary S. Nye Award for Physician Health and Well-Being for her longstanding commitment to physician health in her local community and in the state of California, as well as her career-long contributions to medical ethics.

6 Dec 2014

Talyst to exhibit new products at ASHP MidYear Meeting

Talyst, a market leader in pharmacy automation and 340B solutions, will be exhibiting at the 2014 American Society of Health-System Pharmacists MidYear Meeting in Anaheim, CA December 8 - 10. The company will be showcasing its acute care pharmacy automation solutions, long term care solutions and 340B software products and services.

6 Dec 2014

Promising anti-malarial compound uses novel mechanism to kill malaria parasite

An international research collaborative has determined that a promising anti-malarial compound tricks the immune system to rapidly destroy red blood cells infected with the malaria parasite but leave healthy cells unharmed. St. Jude Children's Research Hospital scientists led the study, which appears in the current online early edition of the Proceedings of the National Academy of Sciences.

5 Dec 2014

Survey: Rising health care costs prompt local governments to make changes to plans, strategies

Although health care costs have slowed recently, rising costs over the last decade have prompted many local governments to make changes to their plans and strategies, according to a new nationwide survey by the Center for State and Local Government Excellence.

5 Dec 2014

Jakafi receives expanded approval from FDA for use in treatment of polycythemia vera

Diplomat Pharmacy, Inc., the nation's largest independent specialty pharmacy, announced that the U.S. Food and Drug Administration has approved an expanded indication of Jakafi (ruxolitinib).

5 Dec 2014

FDA Advisory Committee votes in favor of Actavis' ceftazidime-avibactam

Actavis plc today announced that the Anti-Infective Drugs Advisory Committee convened by the U.S. Food and Drug Administration has voted to recommend approval of Actavis' New Drug Application (NDA) for ceftazidime-avibactam, an investigational antibiotic being developed to treat hospitalized patients when limited or no treatment options are available for complicated intra-abdominal infections (cIAI) (in combination with metronidazole) and complicated urinary tract infections (cUTI) (including acute pyelonephritis) caused by Gram-negative pathogens.

5 Dec 2014

IRC plans to deploy electronic medical records in fight against Ebola

The International Rescue Committee today announced that it is testing and plans to deploy electronic medical records in the fight against Ebola.

5 Dec 2014

Tecomet completes acquisition of Symmetry Medical's OEM Solutions business

Tecomet Inc., a Genstar Capital portfolio company and precision contract manufacturer supporting the medical device and aerospace industries, announced today that it has completed the previously announced acquisition of Symmetry Medical's OEM Solutions business. This acquisition creates the largest orthopedic contract manufacturer in the world with 18 facilities located in five countries on three continents.

5 Dec 2014

University of Miami researcher reveals association between 'salience processing' and brain disorders

How does the brain determine what matters? According to a new scientific article, a brain structure called the insula is essential for selecting things out of the environment that are "salient" for an individual, and dysfunction of this system is linked to brain disorders such as autism, psychosis and dementia.

5 Dec 2014

Ashish Nimgaonkar wins AGA-Boston Scientific Career Development Technology & Innovation Award

The American Gastroenterological Association Research Foundation is pleased to announce that Ashish Nimgaonkar, MBBS, MTech, MS, from John Hopkins University, has received the inaugural AGA-Boston Scientific Career Development Technology & Innovation Award. This award is graciously supported by a grant from Boston Scientific, a leading innovator of medical solutions.

5 Dec 2014

Medical News

Study suggests Golgi as potential drug target for Alzheimer's treatment

Genetics may play major role in Lou Gehrig's disease, study reveals

Research findings may lead to new ways to thwart drug resistance

Study sheds new light on well-known mechanism required for immune response

Study links poor semen quality to higher risk of various health conditions

Researchers suggest new strategy to control cellular identity and fate

Malnutrition predicts long-term survival in elderly patients undergoing Whipple procedure

Researchers identify important neural mechanism responsible for certain chronic pain disorders

University of Utah professor develops MORE intervention program for chronic pain patients

Exposure to chemicals used in UOG operations may affect reproductive and developmental health

Maria T. Lymberis to receive 2014 Gary S. Nye Award for Physician Health and Well-Being

Talyst to exhibit new products at ASHP MidYear Meeting

Promising anti-malarial compound uses novel mechanism to kill malaria parasite

Survey: Rising health care costs prompt local governments to make changes to plans, strategies

Jakafi receives expanded approval from FDA for use in treatment of polycythemia vera

FDA Advisory Committee votes in favor of Actavis' ceftazidime-avibactam

IRC plans to deploy electronic medical records in fight against Ebola

Tecomet completes acquisition of Symmetry Medical's OEM Solutions business

University of Miami researcher reveals association between 'salience processing' and brain disorders

Ashish Nimgaonkar wins AGA-Boston Scientific Career Development Technology & Innovation Award

How real-time off-gas analysis improves fermentation process control

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

AI-powered analytics and experimental validation

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