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Study indicates major added benefit of propranolol in some children with haemangioma

The Institute for Quality and Efficiency in Health Care (IQWiG)investigated in a dossier assessment whether propranolol offers an added benefit in comparison with the appropriate comparator therapy in infants with proliferating infantile haemangioma (sometimes called "strawberry mark").

7 Dec 2014

BUSM's Carmela Abraham receives 2014 Massachusetts Neuroscience Consortium Award

Carmela Abraham, PhD, professor of biochemistry and pharmacology at Boston University School of Medicine, was one of six recipients of this year's Massachusetts Neuroscience Consortium Award out of nearly 60 applicants. The grant was awarded to her for her work on multiple sclerosis and the role of the life extension protein Klotho in the limited repair of white matter in the disease.

7 Dec 2014

Three-drug combination produces better results in multiple myeloma patients

In the treatment of multiple myeloma, the addition of carfilzomib to a currently accepted two-drug combination produced significantly better results than using the two drugs alone, according to a worldwide research team led by investigators from Mayo Clinic.

7 Dec 2014

Adding maintenance therapy after transplant can improve outcomes in Hodgkin lymphoma patients

In a late-stage clinical trial, Hodgkin lymphoma (HL) patients who received brentuximab vedotin (BV) post-transplant lived longer without disease progression than patients who received only supportive care. This is the first time a study has demonstrated that adding a maintenance therapy after transplant can improve outcomes.

7 Dec 2014

Researchers reveal that genetic mutations may cause more cases of ALS

Genetic mutations may cause more cases of amyotrophic lateral sclerosis (ALS) than scientists previously had realized, according to researchers at Washington University School of Medicine in St. Louis and Cedars-Sinai Medical Center in Los Angeles. The scientists also showed that the number of mutated genes influences the age when the fatal paralyzing disorder first appears.

7 Dec 2014

Innovative cell therapy shows highly promising results in pediatric patients with ALL

An innovative cell therapy against a highly aggressive form of acute lymphoblastic leukemia (ALL) continues to show highly promising results in children treated in a pilot study. Ninety-two percent of the 39 children receiving bioengineered T cells had no evidence of cancer at one month after treatment, with this complete response persisting in some cases for more than two years.

7 Dec 2014

MorphoSys, Xencor announce final results from MOR208 Phase 1/2a trial in patients with CLL/SLL

MorphoSys AG and Xencor Inc. today announced the publication of final results of a Phase 1/2a trial evaluating MOR208 (formerly XmAb5574) in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL).

7 Dec 2014

IMBRUVICA demonstrates anti-tumor activity against multiple myeloma in Phase II study

New IMBRUVICA (ibrutinib) Phase II data announced here today by Pharmacyclics, Inc) during the 56th American Society of Hematology Annual Meeting suggests that IMBRUVICA demonstrates anti-tumor activity both as a single-agent and as combination therapy in heavily pre-treated patients with relapsed or relapsed/refractory multiple myeloma (MM).

7 Dec 2014

Orexo announces positive results from ISTART/006 study

Orexo US, Inc. announced results from the ISTART/006 study, being presented today at the 25th Annual Meeting and Symposium of the American Academy of Addiction Psychiatry in Aventura, Florida, USA.

7 Dec 2014

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Novel treatments that harness the body's own immune cells to attack cancer cells demonstrate safe and durable responses in patients with relapsed and treatment-resistant blood cancers, according to data presented today at the 56th American Society of Hematology Annual Meeting and Exposition.

7 Dec 2014

Drugs we release into the environment significantly affect plant growth, study reveals

The drugs we release into the environment are likely to have a significant impact on plant growth, a new study has revealed.

6 Dec 2014

NIH Collaboratory provides guide to success for pragmatic clinical trials

Pragmatic clinical trials--real-life tests done in real-world settings--are increasingly important for answering pressing questions about how best to deliver health care. But these pragmatic trials require close collaboration between two professional groups who often have contrasting styles. One group is researchers, who follow structure like classical musicians. The other is and health care providers and administrators, who may need to improvise like jazz musicians.

6 Dec 2014

Researchers assess efficiency and safety of breast milk stimulant

Most women can make all the milk their baby needs, but some mothers turn to medications to help increase their supply. While some specialists encourage the off-label use of domperidone to stimulate breast milk production, some studies have suggested it may be related to negative side effects, including irregular heartbeat and sudden cardiac death.

6 Dec 2014

Scientists suspect role of mini-chromosomes in cancers, diseases caused by gene mutations

Cancers are due to genetic aberrations in certain cells that gain the ability to divide indefinitely. This proliferation of sick cells generates tumors, which gradually invade healthy tissue. Therefore, current therapies essentially seek to destroy cancer cells to stop their proliferation. Through high-throughput genetic sequencing of glioblastoma cells, one of the most deadly brain tumors, a team of geneticists from the University of Geneva's (UNIGE) Faculty of Medicine discovered that some of these mutations are caused by supplemental extrachromosomal DNA fragments, called double minutes, which enable cancer cells to better adapt to their environment and therefore better resist to treatments meant to destroy them.

6 Dec 2014

Comb-shaped polymers efficiently protect proteins in vivo

An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS Énergie Matériaux Télécommunications Research Centre Professor Marc A. Gauthier explains in an article published in the journal Nature Communications, a polymer was used to camouflage the enzyme before it was injected into the rodents. This was achieved by coating the enzyme to avoid an immune response in a manner that does not compromise its activity.

6 Dec 2014

Gap between hospital costs and charges widens significantly, finds new research

The gap between hospital costs and charges has widened significantly. With individuals increasingly responsible for more of their bill and hospitals grappling with payment cuts and payment reforms, charges matter more than ever. New research shows the rise drastically outpaces inflation during the same time and details the rise in cost-to-charge ratio by state.

6 Dec 2014

March of Dimes Celebration of Babies event raises record $1.1 million

March of Dimes, the leading non-profit organization for pregnancy and baby health, raised a record $1.1 million at their 9th annual March of Dimes Celebration of Babies: A Hollywood Luncheon event today at the Beverly Wilshire Hotel in Los Angeles. The 2014 honorees were actor/filmmaker Elizabeth Banks, who was presented with the March of Dimes Grace Kelly Award and Elizabeth Gabler, President, Fox 2000 who was named the March of Dimes Inspiring Woman of the Year.

6 Dec 2014

Study sheds light on common psychosocial barriers affecting HPV vaccination in Puerto Rico

Young Puerto Rican women and their mothers know little about the human papillomavirus (HPV) and cervical cancer, according to researchers at The University of Texas Health Science Center at Houston School of Public Health.

6 Dec 2014

BRI signs license agreement with SOBI for Kineret (anakinra)

Baylor Research Institute, the research arm of the Baylor Scott & White Health, announced that it has signed an agreement with Swedish Orphan Biovitrum AB (Sobi) to non-exclusively license Baylor's patents pertaining to the treatment of Systemic Onset Juvenile Idiopathic Arthritis (SJIA or SOJIA) using interleukin-1 (IL-1) beta antagonists.

6 Dec 2014

ACSM unveils strategic plan to improve health, fitness outcomes in Cincinnati

The American College of Sports Medicine, with support from the Anthem Blue Cross and Blue Shield Foundation, is expanding the ACSM American Fitness Index Technical Assistance Program to Cincinnati. Working with the Cincinnati Health Department's Creating Healthy Communities Coalition, ACSM unveiled a comprehensive strategic plan today that will guide the Cincinnati metro area toward improved health and fitness outcomes.

6 Dec 2014

Medical News

Study indicates major added benefit of propranolol in some children with haemangioma

BUSM's Carmela Abraham receives 2014 Massachusetts Neuroscience Consortium Award

Three-drug combination produces better results in multiple myeloma patients

Adding maintenance therapy after transplant can improve outcomes in Hodgkin lymphoma patients

Researchers reveal that genetic mutations may cause more cases of ALS

Innovative cell therapy shows highly promising results in pediatric patients with ALL

MorphoSys, Xencor announce final results from MOR208 Phase 1/2a trial in patients with CLL/SLL

IMBRUVICA demonstrates anti-tumor activity against multiple myeloma in Phase II study

Orexo announces positive results from ISTART/006 study

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Drugs we release into the environment significantly affect plant growth, study reveals

NIH Collaboratory provides guide to success for pragmatic clinical trials

Researchers assess efficiency and safety of breast milk stimulant

Scientists suspect role of mini-chromosomes in cancers, diseases caused by gene mutations

Comb-shaped polymers efficiently protect proteins in vivo

Gap between hospital costs and charges widens significantly, finds new research

March of Dimes Celebration of Babies event raises record $1.1 million

Study sheds light on common psychosocial barriers affecting HPV vaccination in Puerto Rico

BRI signs license agreement with SOBI for Kineret (anakinra)

ACSM unveils strategic plan to improve health, fitness outcomes in Cincinnati

How real-time off-gas analysis improves fermentation process control

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

AI-powered analytics and experimental validation

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