Cannabis abuse affects long-term memory, finds new Northwestern Medicine study

Teens who were heavy marijuana users - smoking it daily for about three years -- had an abnormally shaped hippocampus and performed poorly on long-term memory tasks, reports a new Northwestern Medicine study.

The hippocampus is important to long-term memory (also known as episodic memory), which is the ability to remember autobiographical or life events.

The brain abnormalities and memory problems were observed during the individuals' early twenties, two years after they stopped smoking marijuana.

Young adults who abused cannabis as teens performed about 18 percent worse on long-term memory tests than young adults who never abused cannabis.

"The memory processes that appear to be affected by cannabis are ones that we use every day to solve common problems and to sustain our relationships with friends and family," said senior author Dr. John Csernansky, the Lizzie Gilman professor and chair of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital.

The study will be published March 12 in the journal Hippocampus.

The study is among the first to say the hippocampus is shaped differently in heavy marijuana smokers and the different looking shape is directly related to poor long-term memory performance. Previous studies of cannabis users have shown either the oddly shaped hippocampus or poor long-term memory but none have linked them.

Previous research by the same Northwestern team showed poor short-term and working memory performance and abnormal shapes of brain structures in the sub-cortex including the striatum, globus pallidus and thalamus.

"Both our recent studies link the chronic use of marijuana during adolescence to these differences in the shape of brain regions that are critical to memory and that appear to last for at least a few years after people stop using it," said lead study author Matthew Smith, assistant professor of psychiatry and behavioral sciences at the Feinberg School of Medicine.

The longer the individuals were chronically using marijuana, the more abnormal the shape of their hippocampus, the study reports. The findings suggest that these regions related to memory may be more susceptible to the effects of the drug the longer the abuse occurs.

The abnormal shape likely reflects damage to the hippocampus and could include the structure's neurons, axons or their supportive environments.

"Advanced brain mapping tools allowed us to examine detailed and sometimes subtle changes in small brain structures, including the hippocampus," said Lei Wang, also a senior study author and an assistant professor of psychiatry and behavioral sciences at Feinberg. The scientists used computerized programs they developed with collaborators that performed fine mappings between structural MRIs of different individuals' brains.

Subjects took a narrative memory test in which they listened to a series of stories for about one minute, then were asked to recall as much content as possible 20 to 30 minutes later. The test assessed their ability to encode, store, and recall details from the stories.

The groups in the study started using marijuana daily between 16 to 17 years of age for about three years. At the time of the study, they had been marijuana free for about two years. A total of 97 subjects participated, including matched groups of healthy controls, subjects with a marijuana use disorder, schizophrenia subjects with no history of substance use disorders, and schizophrenia subjects with a marijuana use disorder. The subjects who used marijuana did not abuse other drugs.

The study also found that young adults with schizophrenia who abused cannabis as teens performed about 26 percent more poorly on memory tests than young adults with schizophrenia who never abused cannabis.

In the U.S., marijuana is the most commonly used illicit drug, and young adults have the highest -- and growing -- prevalence of use. Decriminalization of the drug may lead to greater use. Four states have legalized marijuana for recreational use, and 23 states plus Washington D.C. have legalized it for medical use.

Because the study results examined one point in time, a longitudinal study is needed to definitively show if marijuana is responsible for the observed differences in the brain and memory impairment, Smith said.

"It is possible that the abnormal brain structures reveal a pre-existing vulnerability to marijuana abuse," Smith said. "But evidence that the longer the participants were abusing marijuana, the greater the differences in hippocampus shape suggests marijuana may be the cause."


Northwestern University


  1. Arock Duece Arock Duece United States says:

    I bet the Cannabis used had solvents left in it and wasn't flushed all the way, also I bet the Cannabis used wasn't cured properly, And the strain used probably had less than 0.87% Cannabidiol which by Federal Standards makes the marijuana unsafe because of Side Effects of Tetrahydrocannabinol (THC) the federal government during 1977-1983 at virginia did medicinal studies and found you need minimum 0.87% CBD to counter the negative side effects of THC like anxiety paranoia, and the worst case scenario psychosis from everyday heavy use for years . Bottom line I bet they didn't even grow the marijuana correctly for this study and had a low CBD strain of Cannabis. It was set up to fail from the beginning like most marijuana studies were the last 70 years.

  2. Herb Reason Herb Reason United States says:

    The last time Northwestern did a study on the effects of cannabis on the brain [Gilman et al. 2014] they claimed something similar but had horrible controls, the cannabis using group used much more alcohol and cigarettes than controls. That study was soon refuted with a new study that properly controlled for alcohol use [Weiland et al. 2015].

    The authors of this new Northwestern study admit causation has not been determined: "Although the results may be compatible with a causal hypothesis, we must consider that the observed cannabis-related shape differences in the hippocampus could also be explained as biomarkers of a neurobiological susceptibility to poor memory or the effects of cannabis". There were only 10 subjects in this study who used cannabis heavily as teens, this is not a large sample.

    Regardless, only a legal, regulated system can reduce regular teen access. It is better to have some control over the 20 millions pounds traded yearly in the U.S. rather than no control.

  3. Max Wood Max Wood United States says:

    "Heavy marijuana use" suggests Joint-$moking (and the article offers no details about how the cannabis for this study was ingested).   A Joint is a drug cocktail of heat shock, carbon monoxide (CO) and 4221 Combustion toxins known to cause pathologies conveniently attributed to the cannabis.  

    Recent studies have in fact suggested that "heavy" tobacco $igarette $moking produces cognitive deficits such as those here linked to cannabis.  The key fact is that today VAPORISERS and flexdrawtube one-hitters (25 mg per serving instead of 500) exist which eliminate the monoxidal "heavy use" $moking hazards-- but PROHIBITION creates conditions under which the Joint remains popular because it is easier to HIDE from your Mom or the cop, or quickly used up thus disposed of at later health cost.  And municipalities have had "Paraphernalia Laws" which make it hazardous to possess or be caught with safer alternatives to $igarette paper.

    The greatest "danger" with cannabis legalization is that it will bring with it legalization of vapes, which may spread over into the tobacco-using population, destroy the $igarette "industry" worldwide and save 6,000,000 lives a year.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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