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In vivo dopaminergic imaging strongly correlates with brain pathology

Striatal dopamine transporter binding, assessed using single-photon emission computed tomography, is strongly correlated with substantia nigra cell counts assessed at postmortem, say the authors of a study.

11 Aug 2014

$Sacral magnetic stimulation effective in refractory stress incontinence$

Sacral magnetic stimulation effective in refractory stress incontinence

Sacral magnetic stimulation may be an effective treatment for stress urinary incontinence in women whose symptoms are refractory to standard therapies, a clinical trial suggests.

11 Aug 2014

Opioid compliance checklist shows promise for chronic pain management

Researchers have developed a brief and simple checklist that clinicians can use to monitor opioid adherence among people with chronic pain.

11 Aug 2014

Mucosal lymphoid cells key to S. pneumoniae defence

Type 3 innate lymphoid cells in the lung mucosa are activated early in the course of infection with Streptococcus pneumoniae and are a major source of interleukin-22 production, research reveals.

11 Aug 2014

First-line sunitinib superior to everolimus for metastatic RCC

Results for the RECORD-3 trial support the current strategy of first-line sunitinib followed by second-line everolimus for the treatment of patients with metastatic renal cell carcinoma.

11 Aug 2014

Midlife hypertension link to later-life cognitive decline strengthened

Analysis of the Atherosclerosis Risk in Communities study cohort supports an association between elevated blood pressure in midlife and increased cognitive decline in older age.

11 Aug 2014

Baseline characteristics influence Parkinson’s disease course

Motor progression in Parkinson’s disease is non-linear and occurs in three distinct phases, all of which are affected by baseline variables such as gender, age at diagnosis, disease subtype, cognitive status and motor score, study findings indicate.

11 Aug 2014

Researchers discover how immunosensory system attacks viruses on a molecular level

Our immunosensory system detects virus such as influenza via specific characteristics of viral ribonucleic acid. Previously, it was unclear how the immune system prevents viruses from simply donning molecular camouflage in order to escape detection.

11 Aug 2014

CRI researchers identify gene linked to several childhood cancers

Researchers at the Children-s Medical Center Research Institute at UT Southwestern have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers.

11 Aug 2014

GW researcher awarded grant to develop a model system to study PN infection

According to a recent World Health Organization report of the leading causes of death worldwide, one-third of all deaths are due to infectious and parasitic diseases. There are currently no vaccines for parasitic nematode (PN), or worm infections in humans, and development of new drugs and vaccines will stall until researchers have a better understanding of PN biology.

11 Aug 2014

Antimalarial agent chloroquine normalizes abnormal tumor blood vessels

A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the one hand -- thereby blocking cancer cell dissemination and metastasis -- and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

11 Aug 2014

TAXIS acquires novel antimicrobial drug candidates from Biota

TAXIS Pharmaceuticals, Inc. today announced the acquisition of a group of novel antimicrobial drug candidates from Biota Pharmaceuticals Inc. of Atlanta, GA.

11 Aug 2014

ALS Association awards 21 new research grants to find cure for amyotrophic lateral sclerosis

The ALS Association announced today that it has awarded 21 new research grants totaling nearly $3.5 million to find treatments and a cure for amyotrophic lateral sclerosis (ALS). The grants were awarded to scientists from laboratories located in nine different states in the United States as well as from the United Kingdom, France, Canada, Switzerland, Israel and Australia.

11 Aug 2014

MCMC announces sale of MCRS program business to PCM

MCMC LLC is pleased to announce the strategic sale of its Managed Care Risk Services program business to Patriot Care Management, Inc., an affiliate of Patriot National Insurance Group.

11 Aug 2014

Medicaid, CHIP enrollments top 7 million

The Department of Health and Human Services reported Friday that 7.2 million people gained insurance through these programs since the health law's eligibility changes began last October. In addition, Arkansas and New Hampshire offer snapshots of their states' enrollment pictures, while Kansas and Missouri hospitals brace for the price of state decisions not to expand the low-income health insurance program.

11 Aug 2014

SCILEX completes patient enrollment to study Ztlido for treatment of postherpetic neuralgia

SCILEX Pharmaceuticals, Inc., a company engaged in the development and commercialization of late-stage pharmaceutical products focused on the treatment of pain, announced today that it has completed patient enrollment for the dermal safety studies and the pivotal pharmacokinetic study related to its investigational product Ztlido (lidocaine patch 1.8%), a next-generation branded lidocaine patch for the treatment of postherpetic neuralgia, also referred to as "after-shingles pain."

11 Aug 2014

Chiltern earns Gold Membership in CDISC

Chiltern International Limited (Chiltern), a global contract research organization (CRO) has earned a Gold Membership in CDISC, the Clinical Data Interchange Standards Consortium.

11 Aug 2014

Cardiome Pharma reports record revenues in second quarter 2014

Cardiome Pharma Corp. today reported financial results for the second quarter and six months ended June 30, 2014.

11 Aug 2014

ISO 13485:2003 certification for Advanced Cell Diagnostics

Advanced Cell Diagnostics, Inc. (ACD), a global technology and market leader in in situ nucleic acid detection for life science research and clinical diagnostics, has been granted ISO 13485:2003 certification, an international quality standard for medical devices, paving a path for ACD to launch its CE marked diagnostic tests in Europe.

From Advanced Cell Diagnostics 11 Aug 2014