Dental therapy that regenerates the tooth enamel rather than drilling

Unlike skins or bones, the tooth enamel, which forms the hard surface of a tooth, does not regenerate itself once damaged. Therefore, the conventional dental treatment includes drilling of the decayed part of a tooth and filling the hole with resin or metal alloy dental materials.

However, such therapy has its limits in the sense that it makes the teeth liable to recur. The problem is that 60% of dental therapy is said to be a retreatment of the teeth once treated, and that is because the dental materials such as resin or metal alloy are totally different from a tooth in composition and structure, and those differences cause tooth decay at the contact point.

Dental therapy that regenerates the tooth enamel rather than drilling the decayed part is the ultimate approach to therapy which every dentist in the world should seek. Dr. Kazue Yamagishi of the FAP Dental Institute has succeeded in developing such a therapy, and thinks in the near future that this therapy will provide a tremendous decrease in the total incidence of tooth decay by applying it to tooth decay prevention.

Dr. Kazue Yamagishi FAQ's

Could this paste be made into a toothpaste that people could brush with daily?

    No, this paste cannot be made into a toothpaste because of its strong acidity. When this paste is applied, the gum must be protected under a dentist's supervision, otherwise the gum will be chemical-burned.

    Does it help natural enamel grow back, or plug holes?

    This synthetic enamel not only repairs teeth but also protects teeth from cavity at the same time.

    When might this be available for use by dentists?

    I don't think it will take long, maybe within two to three years, because presently there is no method for tooth cavity prevention which everyone needs. However, we need more clinical tests to confirm the safety of this therapy for the approval. The small number of the clinical application at my clinic may not be enough clinical data.

    How far along in development is this paste? Is it in clinical trials?

    Yes, it is now in clinical trials. I'm running clinical trials for the approval in Japan, but there is no plans to run clinical trials in EU or USA, yet.

    How is synthetic enamel applied?

    Procedures of the treatment:
    (1) Brush the tooth to clean the surface of early dental caries using toothbrush with toothpaste on it.
    (2) Apply the synthetic enamel paste to the decayed part of the tooth, and allow it to act for 15 minutes.
    (3) Wipe off the paste from the tooth surface of the dental enamel, and wash in water, then dry.
    (4) Brush up the crystallized synthetic enamel to make it shiny.

    Once applied, is the bond so integrated that the repair cannot be detected later?

    The bond is integrated in the composition level, but the color of the apatite is whiter than the normal tooth color, so the repair could possibly be detected later.

    how does this paste repair cavities?

    This dissolution and regrowth process occurs due to the low pH(< 2) of the mother solution and the paste, which forms a continuous structure from the enamel to the re-grown layer on a nanometer scale.

    Your paper mentions that the synthetic material works best on "tiny, early lesions." Could you please give an approximate size range?

    Dental caries causes the crystal forming the teeth to melt under the teeth surface before it actually creates holes on the teeth surface. The teeth in such a condition look white (white spotted). The synthetic enamel can be applied to the lesions that have no holes but melted under teeth surface to the lesions that have holes of tens of micrometer depth. Since the grown layer is estimated to be 30-50 mm thick, whether this paste works or not depends on the depth of the hole, not the width.

    Do you have to color the paste to match the patient's tooth color?

    No, coloring of the paste is not necessary since the tooth becomes whiter after the treatment. Also, if you put some pigment to color the paste, it causes the crystal to change its structure, and the reaction of the synthetic enamel will change, so I don't recommend it.

    Was the premolar tooth you tested it on a human tooth?

    Yes, it was an extracted human premolar tooth.

    Was that tooth treated while it was in a person's mouth, or was it isolated in a laboratory?

    The tooth was extracted for the reason of orthodontic treatment. It was kept in distilled water for less than 1 year before used in a laboratory.

    What is the treatment using acidic phosphate flouride solution as you mentioned in your paper? Is this how dentists normally repair early caries lesions?

    The acidic phosphate fluoride solution is applied to the early caries lesion for the purpose of remineralization. This remineralization therapy is recommended by FDI and accepted by most of the dentists. However, this method requires the multiple appointments with the dentist and long period for the remineralization of the caries lesions.

    How do dentists normally treat such tiny early caries? Do they treat them at all?

    Instead of the remineralization therapy, filling of dental materials such as composite resin and amalgam, are applied to the drilled cavity. This restoration technique was dramatically improved by the development of adhesive filling materials. This method is the so-called minimally invasive restoration technique. In this treatment, the amount of the intact tooth substance is limited since the filling can be bonded to the tooth. However, the bonding is still not perfect, and the recurrent caries around the filling often occurs. Another option is the observation of the early lesion. During this period, the tooth brushing instruction and topical phosphate fluoride application are done.

    Why is it important to treat such tiny caries?

    Such tiny caries is the critical situation between the healthy condition and cavity formation. Once the cavity is formed, the drill-and-fill treatment has to be applied. Most of the early caries lesions is confirmed to be reversible stage of dental caries. If the cavity and the lesions become larger, the life of the tooth will be shortened.

    What happens to the decayed parts of the tooth when this paste is put over them? Do they continue to decay? Or does the application of the paste stop the decay?

    It stops the decay. Because, the decay occurs and continues by bacteria. Synthetic enamel covers the tooth surface. Therefore bacteria cannot survive because of lack of nutrition.

    How long will the material last on a tooth? Can it decay in the same way as normal tooth enamel?

    I cannot tell you the accurate period, but it stands after 10,000 times of brushing. It will decay in the same way, but its acid tolerance becomes higher because of its highly crystalline F-HAP crystals.


    1. Marilyn Campbell Marilyn Campbell United States says:

      How are you coming at bringing your tooth enamel therapy into the US?

    2. J.R. J.R. United States says:

      USA dentists are very resistant to new ideas that help patients since it does not increase their profit. My teeth and entire body have largely been destroyed by bad dentists by moving grinding down teeth and causing severe TMJ from orthodontics. Other dentists have promised to fix these problems but thru incompetence and intentional fraud have made them worse.

      The dental profession here and the govt regulators are so slow and uncaring and political it may be very long before this wonderful idea was available in the USA. I hope dentistry in Japan has a higher integrity level with such fine professionals as the author.
      I already do my own dental work on bite splints and making false teeth out of frustration from the horrible and expensive services I got. So my solution is to make my own dental paste and treat myself. The materials are available such as the food grade H2O2 which I already have. I mainly just need a lab oven from ebay and I expect to grow my teeth back and even restore my bite in doing so.  I expect about 10 treatments on the most damaged teeth should increase thickness by 1/2 mm which should be close to normal.

      • Marilyn Marilyn United States says:

        You do your own dental work? You grow your own teeth? Do you have a website?

      • Robert Nelson DDS Robert Nelson DDS United States says:

        Strange that you report being attacked by bad dentists and going to incompetent dentists whom commit fraud...yet you are willing to experiment on yourself with a technique that sounds plausible, yet has little to no research support.

        In your victim-life you are tormented by bad dentists, incompetent dentists, dental professions, government regulators...what a horrible world you exist in.

        You comment that USA dentists are resistant to new ideas...I would think new ideas that helped patients would only add to the profits of the business end of dentistry.  Maybe waiting to see if a proposed method of treatment actually benefits patients and is safe and efficacious would seem prudent.

        Good luck

      • Marilyn Marilyn United States says:

        "Little to no research support?" What planet are you living on, Robert Nelson, DDS.  BTW, that's "who" not "whom."

        Anyway, to get to my questions. Is the dental paste you have made for cleaning your teeth or for replacing the enamel? What is it made of? You say "the materials are available." Where? from whom? What is the technical name of the lab oven? What do you put into the search feature to find such an oven. How do you grow your own teeth? Where do you get "food grade H020" and how is it used to grow your teeth back? I would appreciate receiving this information and more, if I could.

      • Marilyn Marilyn United States says:

        How can I find out some of the particulars of DIY tooth therapy? I.e., how do you grow your own teeth? What are the components of the paste you make? Where do you get the lab oven and how is it used?  What is the Ho2o used for? Etc.

    3. hindi hindi Germany says:

      Over the world people tell of tooth miracles. I think a lot has to do with a balanced life which is satisfying to us, not just food. Breathing fresh air and a lot other things and you get old and healthy and new natural grown set of teeth.

    4. mahood mahood United States says:

      Hello, I was not blessed with the best genetics when it comes to dental health. I am very interesting in artificial enamel to restore my teeth and prevent further decay.  Is there anyway to find out if I can participate in the clinical trial in the US?

    5. Jan Cameron Jan Cameron United States says:

      The flat surfaces of almost all my teeth are very worn due to grinding. Could this be used to generate enamel before the pulp is exposed ?

    The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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