Single-wall carbon nanotubes targeted and killed cancer cells without harming the healthy cells

www.swentnano.comMar 8 2011

SouthWest NanoTechnologies’ (SWeNT) Single-Wall Carbon Nanotubes (SWCNT) exhibit promising potential for use in biomedical treatments such as cancer photo thermal therapies, new research reveals.

According to an article published in Biophotonics and Immune Responses, researchers in China and the U.S. showed that SWeNT SWcNT “possessed superior Nanoscale interactions and physical properties that make them useful in various biological systems.”

One intrinsic property of SWCNTs is their strong optical absorbance in the near-infrared (NIR) of the spectrum.   As a result, they can be used to selectively increase thermal destruction in target tumors   The SWeNT SWCNT has an intense absorption band at 980-nm.  When radiated with a 980-nm laser, these tubes affect cellular oxidation and destroy the mitochondrial membrane potential causing “apoptosis, or programmed cell death.

“The SWCNTs appear to enter the cytoplasm without cytotoxic effects in cells, and can be used as effective and selective nanomaterials for cancer photo thermal therapy,” explains Wei R. Chen, a researcher at the University of Central Oklahoma.   “The distinct architecture of the SWCNT can shuttle various molecular cargoes, including anticancer drugs and proteins, crossing through cellular membrane without cell disruption.”

“We’re excited by the findings that SWeNT SWCNT killed the cancer cells and didn’t harm the healthy ones,” explains SWeNT CEO Dave Arthur. “These findings distinguish the qualities and special properties of our SWCNT for certain biomedical applications.   We can add biomedical applications to the growing opportunities for SouthWest NanoTechnologies, Inc. as the world leader in high quality, Single-Wall and Specialty Multi-Wall (SMW™) carbon nanotubes.”

The research is supported by the National Basic Research Program of China, the Program for Changjiang Scholars and Innovative Research Team in University and the National Natural Science Foundation of China.

Direct Imaging the Subcellular Localization of Single-Walled Carbon Nanotubes Biophotonics and Immune Responses

Feifan Zhou1, Da Xing1*, Wei R. Chen1,2

1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
2. Biomedical Engineering Program, Department of Engineering and Physics, College of Mathematics and Science, University of Central Oklahoma, Edmond, OK 73034, USA