GPS at WUSTL now offers new cancer genetic test

Physicians can now take advantage of a new genetics test -- one of the first of its kind to be offered in the United States -- that can help determine the best treatment for cancer patients.

Genomics and Pathology Services at Washington University School of Medicine in St. Louis ([email protected]) is now offering a test for mutations in 28 genes associated with cancer. The genes in the test affect a variety of different types of tumors, including blood, lymph, lung, brain, bladder, kidney, skin, stomach, prostate and breast cancers.

Identifying specific mutations in these genes can help doctors decide which treatments are most likely to benefit individual patients, which is the goal of genomic (or personalized) medicine.

All of these genes already can be tested individually for mutations. But using [email protected], physicians throughout the country can order the new test to simultaneously examine the genes most likely to influence treatment of a patient's tumor.

According to [email protected] organizers, sequencing multiple genes at once is less expensive than sequencing the genes separately. The next-generation sequencing technique and the novel bioinformatics platform used to produce the data also will significantly improve the sensitivity and accuracy of the results.

Scientists envision the cancer genetics test as the first of many disease panels to be offered by [email protected] Work is under way on similar panels that will influence the diagnosis and treatment of other disorders, including autism and kidney disease.

"[email protected] is bringing the promise of human genomics to the clinic," says Karen Seibert, PhD, director of [email protected] "We use the latest gene sequencing technology and cross-reference the results to known treatment options for the patient's particular mutations. In addition to patient care, our labs will support clinical trials aimed at identifying new ways to diagnose and treat disease."

While costs for sequencing a patient's entire genome are decreasing, it's still not economically feasible to perform whole-genome sequencing for clinical treatment of patients. Sequencing of multiple genes known to influence a disease will produce the information physicians need to guide treatment decisions.

The services provided by [email protected] will be paid for by a mixture of revenue streams, including health-care insurers, hospitals, patients and federal research grants, and through partnerships with companies and foundations.

"Patients throughout the country can access [email protected] through their personal physician," says John Pfeifer, MD, PhD, vice chairman for clinical affairs in pathology and immunology. "After we receive a patient's tumor sample, results will be returned in days to weeks in a report identifying the mutations detected. We will also provide the names of specific drugs that target the mutations' effects as identified in peer-reviewed medical literature."

[email protected] administrators chose the 28 genes in the first test because all have implications for cancer therapy. The test can easily be adapted to add newly discovered mutations as they are clinically validated.

To describe how multiple genes can affect treatment, [email protected] Medical Director Shashi Kulkarni, PhD, cites acute myeloid leukemia (AML), a blood cancer.

"In AML, patients who have a mutation in a gene called FLT3 can be treated with a drug that suppresses the mutation's effects, improving chances for recovery," Kulkarni says. "Mutations in another gene, DNMT3A, suggest a poor prognosis and call for initial treatment with a bone marrow transplant, a riskier therapy normally reserved for patients whose AML recurs after chemotherapy."

As another example, some lung cancers harbor a mutation in a gene called EGFR. These tumors can be killed much more effectively by specific chemotherapy drugs, so knowledge of the EGFR status helps oncologists choose the best treatment regimen.

The sensitivity of the new sequencing techniques used by [email protected] will be important for cancers, many of which are genetically unstable, notes Jeffrey Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics. This instability results in tumors that contain cells that are genetically different.

"It's possible that an important mutation that makes the tumor harder to kill will be present only in a small percentage of tumor cells," he says. "The new sequencing technology we're using substantially increases our chances of detecting such critical mutations."

[email protected] faculty and technicians will work in laboratories designed and maintained to meet rigorous clinical testing standards.

"All of our labs will meet the requirements of both the College of American Pathologists (CAP) accreditation and Clinical Laboratory Improvement Act (CLIA) certification," says Herbert W. Virgin IV, MD, PhD, the Edward Mallinckrodt Professor and head of the Department of Pathology and Immunology. "Those are the gold standards of laboratory testing, and [email protected] will be among a group of relatively uncommon genetic testing services in the nation to have both of them."

Washington University's new Genome Technology Access Center (GTAC) provides the genetic data interpreted by [email protected] Bioinformatics experts in [email protected] have built a clinical genomicist workstation that can automatically insert references to medical literature that can help doctors assess the treatment options.

"Having the system automatically start the interpretive work will help loosen a major bottleneck that has made it difficult to provide physicians with results of genomic tests in a timely fashion," says [email protected] Bioinformatics Director Rakesh Nagarajan, MD, PhD.

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