Penn Medicine professor receives New Innovator Award from NIH

Hao Wu, PhD, an assistant professor of Genetics in the Perelman School of Medicine at the University of Pennsylvania has received a New Innovator Award from the National Institutes of Health (NIH). These awards provide each recipient $1.5 million over five years to pursue high-risk, high-reward investigations that could have implications for human health. Wu's grant is among 89 announced last week "to highly creative and exceptional scientists with bold approaches to major challenges in biomedical research," according to the NIH announcement.

The New Innovator Award, established in 2007, supports unusually innovative research from early career investigators who are within 10 years of their final degree or clinical residency and have not yet received a research project grant or equivalent NIH grant. For 2017, NIH granted 55 New Innovator awards, as well as 12 Pioneer awards, 8 Transformative Research awards, and 11 Early Independence awards, all part of the NIH High-Risk, High-Reward Research program,

"I continually point to this program as an example of the creative and revolutionary research NIH supports," said NIH Director Francis S. Collins, MD, PhD. "The quality of the investigators and the impact their research has on the biomedical field is extraordinary."

Wu, also a core member of the Epigenetics Institute, came to Penn in 2016. His lab develops profiling and editing tools to investigate molecular interactions between environmental factors such as oxygen levels in tissues and the epigenome, a battery of chemical marks that control gene expression. Oxygen acts as a critical helper cofactor for many key epigenetic enzymes.

Recent studies suggest that cells can rapidly adapt to changing environmental inputs by modifying their epigenome and therefore which genes are expressed. Wu's lab is interested in investigating the molecular underpinnings regulating this interaction and its relationship to developmental processes and human diseases.

Wu's new grant will fund his study of how the epigenome of heart muscle cells respond and adapt to changing environmental oxygen levels. These heart cells can proliferate and therefore possess regenerative potential in the oxygen-poor environment of a developing embryo before birth but rapidly lose such potential in the oxygen-rich environment of newborn mice or humans that have taken their first breath of air. Better understanding of the molecular program that promotes proliferation of heart muscle cells in the embryos may inform therapeutic approaches to treat adult heart disease.

He proposes to develop single-cell profiling methods and "oxygen-sensing" epigenome editing enzymes to learn how to rewire the epigenome of mammalian heart muscle cells for the purpose of adult heart regeneration. "Armed with these new tools, we will have the ability to observe and actively manipulate the interaction between environmental inputs and the epigenome 'on demand', providing fundamentally new opportunities to study the environment-epigenome interaction involved in a broad array of biological and pathological processes," Wu said.