In utero exposure to opioids was associated with higher risks for short- and long-term adverse outcomes including preterm birth and neurodevelopmental and physical health disorders in children.
This observational study analyzed clinical and epidemiological data for a group of 8,509 mother-child pairs collected at birth starting in 1998, and 3,153 children who continued to be followed after birth up to age 21 years old. Of the 8,509 children, 454 (5.3%) had in utero opioid exposure, which was defined as maternal self-reported opioid use or a clinical diagnosis of neonatal abstinence syndrome for a child. The study reports that in utero exposure to opioids was associated with a higher likelihood of being small for gestational age and preterm birth.
In utero exposure to opioids also was associated with postnatal neurodevelopmental and physical disorders, including a higher likelihood of conduct disorder or emotional disturbance diagnoses, as well as lack of normal physiological development in children before age 6 years old, and later on, a higher likelihood of attention-deficit/hyperactivity disorder. Study limitations to consider include that mothers may have used other substances, such as alcohol, cigarettes, marijuana and stimulants, which could have influenced the outcomes.
Uterine corpus malignancies with pregnancy-like features lead to poor survival outcomes