Fight for Sight funds new project to create UK’s first large-scale glaucoma biobank

Fight for Sight is funding a project to create the UK’s first large-scale glaucoma biobank, a new tool that will help personalize glaucoma treatment and identify patients most at risk of sight loss.

Fight for Sight-funded researcher Dr Anthony Khawaja and his team will establish a data resource to allow better genetic prediction of which glaucoma patients are likely to worsen and therefore require the most intensive treatment. They will be linking data from glaucoma patients at Moorfields Eye Hospital and a national genetics study (the National Institute for Health Research BioResource).

The biobank, called the Moorfields Glaucoma BioResource, will be the first of its kind for glaucoma and comes in response to a recent study part-supported by Fight for Sight undertaken by Dr Khawaja which identified over 100 genetic factors that are associated with intraocular pressure (IOP) and the risk of developing glaucoma.

Finding the right treatment for individual glaucoma patients is complex. It is difficult to predict on diagnosis which patients will require the most intensive form of treatment, and difficult to determine which care will be most effective for individuals. A ‘trial and error’ approach is therefore used, where several treatments are tried in succession until an effective one is found. Some patients worsen despite treatment, while it is thought some patients are over-treated, which is why this research will be so vital.

If this resource is successful, it is hoped that prediction models can be developed so that patients at high risk of losing their sight will be identified from the point of diagnosis, enabling earlier intensive treatment to prevent vision loss. Conversely, patients at low risk of blindness may be saved the costs of unnecessary treatment.

Lead researcher on the project, Dr Anthony Khawaja, said:

With the global glaucoma burden set to increase dramatically due to an ageing population, there is an urgent need to innovate our glaucoma management strategy. If we’re able to successfully develop this resource and establish a genetic prediction model, we hope to better detect the most serious cases of glaucoma to prevent sight loss, and to identify low-risk glaucoma patients to reduce over-treatment and resource misuse.”

Fight for Sight’s Head of Research and Policy, Dr Rubina Ahmed, said:

Research is desperately needed to enable ophthalmologists to determine early on which patients are at high risk of sight loss and require the most intensive care.

A biobank for glaucoma is a much-needed step towards personalizing care and improving the efficacy of treatment for this devastating condition. This will reduce the burden on both patients and the NHS.”

The project is funded through the Fight for Sight Small Grant Award, which will support the establishment of the Moorfields Glaucoma BioResource, data collection processes, database and the first year of recruitment. It is anticipated this will provide a springboard for further funding to continue recruitment beyond the initial 12-month period, to contribute to the UKGGC (UK Glaucoma Genetics Consortium), and to undertake analyses. It is expected that the initial 1,000 participant recruitment to the Moorfields Glaucoma BioResource will be completed in 24 months.

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