Songbird study aims to improve understanding of human speech

The human brain regions responsible for speech and communication keep our world running by allowing us to do things like talk with friends, shout for help in an emergency and present information in meetings.

However, scientific understanding of just how these parts of the brain work is limited. Consequently, knowledge of how to improve challenges such as speech impediments or language acquisition is limited as well.

Using an ultra-lightweight, wireless implant, a University of Arizona team is researching songbirds - one of the few species that share humans' ability to learn new vocalizations - to improve scientific understanding of human speech. A paper about their work was published today in the journal Nature Communications.

"Using new methods of antenna design and optimized electronics, we were able to shrink the devices dramatically compared to existing versions, to about a third of the size of a dime and as thin as a sheet of paper," said lead author Jokubas Ausra, a biomedical engineering doctoral student in the Gutruf Lab, where the devices were created.

There are several ways the device can be used to study the link between brain behavior and vocalization. It can monitor the bird for slight temperature changes that indicate when a bird is most likely to sing. Using a technique called optogenetics, researchers can modulate neuron groups in the brain regions used for birdsong. In this study, the team found that remotely controlling specific neurons during birdsong using their unique device caused the song to change pitch.

We are excited to expand the toolbox of neuroscientists and hope to enable many exciting studies that decipher the working principles of the brain."

Philipp Gutruf, Senior Author, Assistant Professor of Biomedical Engineering and Craig M. Berge Fellow in the UArizona College of Engineering

The Gutruf Lab has developed other wireless lightweight devices used to monitor brain activity in rodents, but birds' ability to move in 3D space represents an added challenge. This tiny device allows the birds to move without restriction - a breakthrough enabled by careful management of the energy sent wirelessly to the implant.

"Because of the small size and light weight, the birds can move freely and live permanently with the implant without affecting their behavior or health, which opens up many possibilities to study the basis for vocal communication," said co-senior author Julie Miller, an assistant professor of neuroscience and speech, language and hearing sciences at UArizona.

The team's next goal is to expand device capabilities to also record neuron activity. This could allow researchers to visualize brain activity during song learning and performance to gain a deeper understanding of the underlying brain mechanisms.

Source:
Journal reference:

Ausra, J., et al. (2021) Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds. Nature Communications. doi.org/10.1038/s41467-021-22138-8.

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