Large heart attack study shows increased survival rates in patients with cardiogenic shock

The results of a large, national heart attack study show that patients with a deadly complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Hospital in collaboration with four metro Detroit hospitals.

Cardiogenic shock is a critical condition in which the heart is unable to pump enough blood to sustain the body's needs, depriving vital organs of blood supply and can cause them to eventually cease functioning. The typical survival rate of this deadly complication during a heart attack has historically hovered around 50%.

Led by a cardiology research team based at Henry Ford Hospital in Detroit, the National Cardiogenic Shock Initiative (NCSI) results demonstrated a survival rate of 71% in patients whose heart attack was complicated by cardiogenic shock and were treated with the protocol. Researchers announced the trial results today at the Society for Cardiovascular Angiography and Interventions (SCAI) 2021 Scientific Sessions.

The National Cardiogenic Shock Initiative is the largest prospective study of therapy for acute myocardial infarction cardiogenic shock done in the United States in the past 20 years."

William O'Neill, M.D., Study Principal Inverstigator and Medical Director, Center for Structural Heart Disease, Henry Ford Health System

"We have found that the original observations of the Detroit Cardiogenic Shock Initiative have been reproduced in 80 hospitals throughout the U.S. If implemented across the country, the National Cardiogenic Shock Initiative protocol could save up to 20,000 lives a year. We strongly believe that our results will be validated in the upcoming Recover IV trial, which should commence enrollment late next year."

Eighty hospitals in 29 states participated in NCSI and agreed to treat patients who presented with acute myocardial infarction and cardiogenic shock using a standard protocol, which involved rapid initiation of mechanical circulatory support (MCS) with an Impella 2.5® or Impella CP® heart pump, along with right heart catheterization to assess status of right and left ventricular heart function. Patients were enrolled between July 2016 and December 2020.

"More than 400 patients from across the country were enrolled in this study, including a third of patients who had already suffered a cardiac arrest," said Babar Basir, D.O., director of the acute mechanical circulatory support program at Henry Ford and principal investigator of the study. "The survival rate of 71% is significantly higher than any other previous study on cardiogenic shock.

The protocol standardizes the process of care provided by nurses, technicians, interventional cardiologists and critical care physicians, providing predictable care in high risk and complex patients. The protocol has already saved many lives and will continue to do so as more hospitals implement its principles."


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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