Ibrutinib plus chemoimmunotherapy prolonged progression-free survival in previously untreated mantle cell lymphoma patients

Combination chemoimmunotherapy with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib demonstrated improved progression-free survival over standard chemoimmunotherapy for previously untreated mantle cell lymphoma (MCL) in patients 65 and over, researchers from The University of Texas MD Anderson Cancer Center reported today at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. The study results also were published today in the New England Journal of Medicine.

The randomized Phase III SHINE clinical trial was conducted at 183 sites in 28 countries since 2013. The double-blinded study evaluated treatment with bendamustine-rituximab and rituximab maintenance plus either ibrutinib or placebo. The primary endpoint was progression-free survival (PFS) assessed by the investigators.

The median PFS was 80.6 months with the ibrutinib combination versus 52.9 months in the control arm. The complete response rate was 65.5% in the ibrutinib arm and 57.6% in the placebo arm. Median overall survival had not been reached in either treatment arm at the time of data cutoff.

The majority of mantle cell lymphoma patients who are diagnosed over age 65 are not able to receive intensive chemotherapy or stem cell transplantation due to the excessive toxicities from treatment. These results provide evidence that an ibrutinib-based combination front-line treatment regimen provides a significant progression-free survival benefit and may be a new treatment opportunity for this patient population who previously had few options."

Michael Wang, M.D., professor of Lymphoma and Myeloma and lead investigator of the study

MCL is a rare and incurable subtype of B-cell lymphoma, accounting for 7% of all non-Hodgkin lymphoma cases. Single agent ibrutinib has transformed the care of patients with relapsed or refractory MCL with durable activity, particularly when used at first relapse, but patients inevitably develop resistance, generally within one to two years. Ibrutinib received accelerated approval from the U.S. Food & Drug Administration to treat MCL patients who have previously received at least one line of therapy.

The SHINE study randomized 523 patients to the two treatment arms. Median age was 71 years, 65.6% of patients had low or intermediate prognostic risk factors on the mantle cell lymphoma international prognostic index (MIPI), and 8.6% had blastoid/pleiomorphic histology. Patients could not have received prior therapies for their disease. Trial participants were representative of the racial breakdown of patients with newly diagnosed MCL, where majority were white (77%).

Ibrutinib treatment was administered during induction and during rituximab maintenance for two years, continuing indefinitely until disease progression or intolerance. Fifty-two (19.9%) and 106 (40.5%) patients received subsequent anti-lymphoma therapy in the ibrutinib and placebo arms, respectively, while 41 of 106 (38.7%) received a second-line BTK inhibitor in the placebo arm.

Grade 3 or 4 treatment-related adverse events occurred in 81.5% of patients in the ibrutinib group and 77.3% in the placebo group. Atrial fibrillation was reported in 13.9% of patients in the ibrutinib arm and 6.5% of patients who received the placebo. The safety profile was consistent with the known profiles of the individual drug, and patients rated their health-related quality of life similarly across both treatment arms.

"This study shows that the ibrutinib combination significantly improved progression-free survival with manageable toxicities," Wang said. "I am encouraged that moving ibrutinib to the front-line setting will improve outcomes in these patients and should change the standard of care for elderly patients with mantle cell lymphoma."

The patients in this study continue to be followed to evaluate differences in overall survival between treatment arms. Future research may investigate chemotherapy-free or time-limited ibrutinib combinations.

The study was funded by Janssen Pharmaceuticals NV, part of the Janssen Pharmaceutical Companies of Johnson & Johnson and Pharmacyclics LLC, an AbbVie Company. Wang has worked in a consulting/advisory role for and received research support from Janssen and Pharmacyclics.