A comprehensive analysis of first monkeypox outbreak in Shenzhen, China

This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen, China encompassing clinical symptomatology, therapeutic approaches, epidemiological research, and comprehensive laboratory tests, aiming to establish a robust reference for future mitigation and management strategies for monkeypox. The investigation involved a thorough study of all identified positive cases, including extensive molecular analysis through nucleic acid detection and whole-genome sequencing of the monkeypox virus. Contact tracing and containment of the infected individuals were also undertaken. Three distinct monkeypox cases were identified in this unique outbreak, exhibiting mild and atypical clinical manifestations, primarily fever and rash. All cases were linked to a single transmission chain, primarily facilitated through close contact and homosexual behavior, indicative of a high-risk factor for monkeypox transmission.


  • MPV Cases exhibited mild and atypical fever and rash.
  • MPXV was detected in nasopharyngeal/oropharyngea/anal swabs and blister fluid.
  • Primarily facilitated through close contact and homosexual behavior.
  • Infected MPXVs are highly homologous to strains from Japan collected in 2023.
Journal reference:

Wan, J., et al. (2023). Investigation into the epidemiology, genetic characteristics, and clinical manifestations of the first monkeypox outbreak in Shenzhen, China. Biosafety and Health. doi.org/10.1016/j.bsheal.2023.08.001.


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